AiPD: Autoinhibited Protein Database

Gene name	Lrguk
Protein name	Leucine-rich repeat and guanylate kinase domain-containing protein
Names
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:74354
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

743-820 (Predicted disordered autoinhibitory region) PR

743-820 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q9D5S7-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs243666235	18	R>L	No	EVA
rs255914696	38	S>R	No	EVA
rs221937840	40	G>S	No	EVA
rs257102820	47	L>M	No	EVA
rs3396463190	50	K>M	No	EVA
rs3388810686	94	E>D	No	EVA
rs264106061	101	K>E	No	EVA
rs223984038	102	Y>N	No	EVA
rs256724685	113	E>G	No	EVA
rs223118049	115	I>L	No	EVA
rs3396676766	131	N>I	No	EVA
rs3388820616	161	I>N	No	EVA
rs3388805792	162	E>K	No	EVA
rs248564154	182	K>N	No	EVA
rs3388816455	187	F>I	No	EVA
rs3388805723	194	N>I	No	EVA
rs3388819177	220	L>P	No	EVA
rs233159239	237	I>T	No	EVA
rs3388815057	298	L>M	No	EVA
rs3388826671	343	P>S	No	EVA
rs3388820649	378	P>R	No	EVA
rs3388820606	394	N>I	No	EVA
rs3388789810	413	P>L	No	EVA
rs3388789817	428	R>Q	No	EVA
rs3388810649	458	G>R	No	EVA
rs3388789753	470	V>I	No	EVA
rs232704416	489	H>Y	No	EVA
rs3388816459	508	S>C	No	EVA
rs3413022599	591	K>R	No	EVA
rs3388826676	609	T>I	No	EVA
rs3388808267	612	P>S	No	EVA
rs3388810657	613	T>I	No	EVA
rs230189787	618	T>M	No	EVA
rs256373956	630	S>P	No	EVA
rs46464233	632	T>A	No	EVA
rs3396374890	641	R>*	No	EVA
rs3388819218	661	E>D	No	EVA
rs3388789816	667	H>R	No	EVA
rs3388800777	701	Y>C	No	EVA
rs256568100	706	D>N	No	EVA
rs243158021	725	T>P	No	EVA
rs218078584	727	P>T	No	EVA
rs240378244	734	N>D	No	EVA
rs3388789751	742	Y>F	No	EVA
rs3388819137	746	C>F	No	EVA
rs250002531	761	I>V	No	EVA
rs255075850	783	A>G	No	EVA
rs3388814984	787	Q>H	No	EVA
rs3388789752	799	I>V	No	EVA
rs220816596	802	M>T	No	EVA
rs3388823006	814	P>T	No	EVA

Type	Name	Position	InterPro Accession
domain	SpoVT-AbrB domain	29 - 74	IPR007159
domain	Toxin SymE-like	20 - 71	IPR014944

		Description
EC Number
Subcellular Localization	Cytoplasmic vesicle, secretory vesicle, acrosome Cytoplasm, cytoskeleton Cytoplasm, cytoskeleton, cilium basal body	Localizes to the acrosome and acroplaxome in round spermatids Localizes to the manchette during spermiogenesis Also found in the basal body of elongating spermatids, and in primary cilia of somatic cells
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
acrosomal vesicle	A structure in the head of a spermatozoon that contains acid hydrolases, and is concerned with the breakdown of the outer membrane of the ovum during fertilization. It lies just beneath the plasma membrane and is derived from the lysosome.
cell projection	A prolongation or process extending from a cell, e.g. a flagellum or axon.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
manchette	A tubular array of microtubules that extends from the perinuclear ring surrounding the spermatid nucleus to the flagellar axoneme. The manchette may also contain F-actin filaments.

Name	Definition
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
guanylate kinase activity	Catalysis of the reaction: ATP + GMP = ADP + GDP.

Name	Definition
axoneme assembly	The assembly and organization of an axoneme, the bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements.
cell differentiation	The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
phosphorylation	The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.
spermatogenesis	The developmental process by which male germ line stem cells self renew or give rise to successive cell types resulting in the development of a spermatozoa.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P15454	GUK1	Guanylate kinase	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	PR
Q8IYG6	LRRC56	Leucine-rich repeat-containing protein 56	Homo sapiens (Human)	PR
Q9H069	DRC3	Dynein regulatory complex subunit 3	Homo sapiens (Human)	PR
Q4LDG9	DNAL1	Dynein axonemal light chain 1	Homo sapiens (Human)	PR
Q6ZRR7	LRRC9	Leucine-rich repeat-containing protein 9	Homo sapiens (Human)	PR
Q96M69	LRGUK	Leucine-rich repeat and guanylate kinase domain-containing protein	Homo sapiens (Human)	PR
Q9DAP0	Lrrc46	Leucine-rich repeat-containing protein 46	Mus musculus (Mouse)	PR
Q6DIQ3	ppp1r7	Protein phosphatase 1 regulatory subunit 7	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	PR