P15454

PR
Gene name
GUK1 (YDR454C, D9461.39)
Protein name
Guanylate kinase
Names
GMP kinase
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YDR454C
EC number
2.7.4.8: Phosphotransferases with a phosphate group as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

5-74 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

5 structures for P15454

Entry ID Method Resolution Chain Position Source
1EX6 X-ray 230 A A/B 2-187 PDB
1EX7 X-ray 190 A A 2-187 PDB
1GKY X-ray 200 A A 2-187 PDB
4F4J X-ray 245 A A/B 1-187 PDB
AF-P15454-F1 Predicted AlphaFoldDB

No variants for P15454

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P15454

No associated diseases with P15454

3 regional properties for P15454

Type Name Position InterPro Accession
domain Guanylate kinase-like domain 2 - 184 IPR008144
domain Guanylate kinase/L-type calcium channel beta subunit 1 - 187 IPR008145
conserved_site Guanylate kinase, conserved site 37 - 54 IPR020590

Functions

Description
EC Number 2.7.4.8 Phosphotransferases with a phosphate group as acceptor
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

2 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
guanylate kinase activity Catalysis of the reaction: ATP + GMP = ADP + GDP.

3 GO annotations of biological process

Name Definition
GDP biosynthetic process The chemical reactions and pathways resulting in the formation of GDP, guanosine 5'-diphosphate.
phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.
purine nucleotide metabolic process The chemical reactions and pathways involving a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q96M69 LRGUK Leucine-rich repeat and guanylate kinase domain-containing protein Homo sapiens (Human) PR
Q9D5S7 Lrguk Leucine-rich repeat and guanylate kinase domain-containing protein Mus musculus (Mouse) PR
10 20 30 40 50 60
MSRPIVISGP SGTGKSTLLK KLFAEYPDSF GFSVSSTTRT PRAGEVNGKD YNFVSVDEFK
70 80 90 100 110 120
SMIKNNEFIE WAQFSGNYYG STVASVKQVS KSGKTCILDI DMQGVKSVKA IPELNARFLF
130 140 150 160 170 180
IAPPSVEDLK KRLEGRGTET EESINKRLSA AQAELAYAET GAHDKVIVND DLDKAYKELK
DFIFAEK