Q9DAP0

PR
Gene name
Lrrc46
Protein name
Leucine-rich repeat-containing protein 46
Names
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:69297
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

147-218 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9DAP0

Entry ID Method Resolution Chain Position Source
AF-Q9DAP0-F1 Predicted AlphaFoldDB

23 variants for Q9DAP0

Variant ID(s) Position Change Description Diseaes Association Provenance
rs27023922 4 D>E No EVA
rs231636681 12 A>T No EVA
rs216094785 16 E>K No EVA
rs3389197509 21 I>F No EVA
rs241878842 70 R>Q No EVA
rs3389171401 72 I>N No EVA
rs3389206749 74 S>G No EVA
rs3389199650 99 L>M No EVA
rs226370125 101 R>G No EVA
rs263635522 107 V>L No EVA
rs3389130973 109 N>Y No EVA
rs3389199661 151 Q>E No EVA
rs3389197199 158 V>M No EVA
rs3389197160 163 P>L No EVA
rs3389206819 168 L>M No EVA
rs225287181 246 A>T No EVA
rs27023941 278 T>S No EVA
rs3389209862 288 K>I No EVA
rs265877219 305 T>S No EVA
rs3389195110 308 A>D No EVA
rs237818100 311 P>T No EVA
rs251687635 316 M>I No EVA
rs246232609 316 M>T No EVA

No associated diseases with Q9DAP0

2 regional properties for Q9DAP0

Type Name Position InterPro Accession
repeat Leucine-rich repeat 71 - 92 IPR001611-1
repeat Leucine-rich repeat 93 - 114 IPR001611-2

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
protein phosphatase type 1 complex A protein complex that possesses magnesium-dependent protein serine/threonine phosphatase (AMD phosphatase) activity, and consists of a catalytic subunit and one or more regulatory subunits that dictates the phosphatase's substrate specificity, function, and activity.

1 GO annotations of molecular function

Name Definition
protein serine/threonine phosphatase inhibitor activity Binds to and stops, prevents or reduces the activity of a serine/threonine protein phosphatase, an enzyme that catalyzes the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + phosphate.

1 GO annotations of biological process

Name Definition
positive regulation of protein dephosphorylation Any process that activates or increases the frequency, rate or extent of removal of phosphate groups from a protein.

7 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q8IYG6 LRRC56 Leucine-rich repeat-containing protein 56 Homo sapiens (Human) PR
Q96M69 LRGUK Leucine-rich repeat and guanylate kinase domain-containing protein Homo sapiens (Human) PR
Q9H069 DRC3 Dynein regulatory complex subunit 3 Homo sapiens (Human) PR
Q4LDG9 DNAL1 Dynein axonemal light chain 1 Homo sapiens (Human) PR
Q6ZRR7 LRRC9 Leucine-rich repeat-containing protein 9 Homo sapiens (Human) PR
Q9D5S7 Lrguk Leucine-rich repeat and guanylate kinase domain-containing protein Mus musculus (Mouse) PR
Q6DIQ3 ppp1r7 Protein phosphatase 1 regulatory subunit 7 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) PR
10 20 30 40 50 60
MPGDEQEAKK AAQRTEEGVH ITEALITKRN LTFPGDEDLS EKMFHTLGEL ETVRLDGEGI
70 80 90 100 110 120
TCIGNLEKLR NIHSLYLQSN KIQRIENLAC ITSLRFLSLA RNQIRHVENL LDLQYLQFLD
130 140 150 160 170 180
LSENLIETLK LDELPESLLI LNLCGNPCTN QEGYRKMVIG ALPLLLDLDK QPILERWTSD
190 200 210 220 230 240
EEDKSSDDDD EFPELNGPFC AERGFFKDLE QELHQHQERR QQAALTEHLS RMETQPVLTD
250 260 270 280 290 300
LPLLPAVPMA GDCSSTATDQ PGKESAPKAT SSTQTASTTK KQVSKNQKSS VQARKGALAA
310 320
TTSKTSQAAT PSMTKMTNKK STK