Q9CXY9
Gene name |
Pigk |
Protein name |
GPI-anchor transamidase |
Names |
GPI transamidase, Phosphatidylinositol-glycan biosynthesis class K protein, PIG-K |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:329777 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9CXY9
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9CXY9-F1 | Predicted | AlphaFoldDB |
13 variants for Q9CXY9
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs212099653 | 11 | V>A | No | EVA | |
| rs243085688 | 13 | T>I | No | EVA | |
| rs3388667803 | 62 | V>A | No | EVA | |
| rs3388659666 | 70 | R>I | No | EVA | |
| rs3388657383 | 85 | M>V | No | EVA | |
| rs3388668207 | 141 | P>H | No | EVA | |
| rs3388664991 | 159 | I>F | No | EVA | |
| rs3388671512 | 167 | N>D | No | EVA | |
| rs3388650860 | 169 | F>L | No | EVA | |
| rs3388668190 | 257 | L>W | No | EVA | |
| rs3388669991 | 295 | P>R | No | EVA | |
| rs226229332 | 333 | D>E | No | EVA | |
| rs3393831816 | 366 | P>H | No | EVA |
No associated diseases with Q9CXY9
No regional properties for Q9CXY9
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q9CXY9 | |||
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| GPI-anchor transamidase complex | An enzyme complex which in humans and yeast consists of at least five proteins; for example, the complex contains GAA1, GPI8, PIG-S, PIG-U, and PIG-T in human, and Gaa1p, Gab1p, Gpi8p, Gpi16p, and Gpi17p in yeast. Catalyzes the posttranslational attachment of the carboxy-terminus of a precursor protein to a GPI-anchor. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| GPI-anchor transamidase activity | Catalysis of the formation of the linkage between a protein and a glycosylphosphatidylinositol anchor. The reaction probably occurs by subjecting a peptide bond to nucleophilic attack by the amino group of ethanolamine-GPI, transferring the protein from a signal peptide to the GPI anchor. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| attachment of GPI anchor to protein | A transamidation reaction that results in the cleavage of the polypeptide chain and the concomitant transfer of the GPI anchor to the newly formed carboxy-terminal amino acid of the anchored protein. The cleaved C-terminal contains the C-terminal GPI signal sequence of the newly synthesized polypeptide chain. |
| protein localization to cell surface | A process in which a protein is transported to, or maintained in, a location within the external part of the cell wall and/or plasma membrane. |
| proteolysis | The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAAPCFLTLR | VATLAALALL | SLGSSAAGHI | EDQAEQFFRS | GHTNNWAVLV | CTSRFWFNYR |
| 70 | 80 | 90 | 100 | 110 | 120 |
| HVANTLSVYR | SVKRLGIPDS | HIVLMLADDM | ACNARNPKPA | TVFSHKNMEL | NVYGDDVEVD |
| 130 | 140 | 150 | 160 | 170 | 180 |
| YRSYEVTVEN | FLRVLTGRVP | PSTPRSKRLL | SDDRSNILIY | MTGHGGNGFL | KFQDSEEITN |
| 190 | 200 | 210 | 220 | 230 | 240 |
| IELADAFEQM | WQKRRYNELL | FIIDTCQGAS | MYERFYSPNI | MALASSQVGE | DSLSHQPDPA |
| 250 | 260 | 270 | 280 | 290 | 300 |
| IGVHLMDRYT | FYVLEFLEEI | NPASQTNMND | LFQVCPKSLC | VSTPGHRTDL | FQRDPKNVLI |
| 310 | 320 | 330 | 340 | 350 | 360 |
| TDFFGSVRKV | EITTEKISLQ | WDSQVVDSSS | KEDGTAEERM | GPLKYAEQLP | VAQIIHQKPK |
| 370 | 380 | 390 | |||
| PRDWHPPGGF | ILGLWALIIM | VFFKTYGIKH | MKFIF |