Q4KRV1

PR
Gene name
PIGK
Protein name
GPI-anchor transamidase
Names
GPI transamidase, Phosphatidylinositol-glycan biosynthesis class K protein, PIG-K
Species
Sus scrofa (Pig)
KEGG Pathway
ssc:606750
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

291-363 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q4KRV1

Entry ID Method Resolution Chain Position Source
AF-Q4KRV1-F1 Predicted AlphaFoldDB

No variants for Q4KRV1

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q4KRV1

No associated diseases with Q4KRV1

No regional properties for Q4KRV1

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q4KRV1

Functions

Description
EC Number
Subcellular Localization
  • Endoplasmic reticulum membrane ; Single-pass type I membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
GPI-anchor transamidase complex An enzyme complex which in humans and yeast consists of at least five proteins; for example, the complex contains GAA1, GPI8, PIG-S, PIG-U, and PIG-T in human, and Gaa1p, Gab1p, Gpi8p, Gpi16p, and Gpi17p in yeast. Catalyzes the posttranslational attachment of the carboxy-terminus of a precursor protein to a GPI-anchor.

1 GO annotations of molecular function

Name Definition
GPI-anchor transamidase activity Catalysis of the formation of the linkage between a protein and a glycosylphosphatidylinositol anchor. The reaction probably occurs by subjecting a peptide bond to nucleophilic attack by the amino group of ethanolamine-GPI, transferring the protein from a signal peptide to the GPI anchor.

3 GO annotations of biological process

Name Definition
attachment of GPI anchor to protein A transamidation reaction that results in the cleavage of the polypeptide chain and the concomitant transfer of the GPI anchor to the newly formed carboxy-terminal amino acid of the anchored protein. The cleaved C-terminal contains the C-terminal GPI signal sequence of the newly synthesized polypeptide chain.
protein localization to cell surface A process in which a protein is transported to, or maintained in, a location within the external part of the cell wall and/or plasma membrane.
proteolysis The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q3MHZ7 PIGK GPI-anchor transamidase Bos taurus (Bovine) PR
Q92643 PIGK GPI-anchor transamidase Homo sapiens (Human) PR
Q9CXY9 Pigk GPI-anchor transamidase Mus musculus (Mouse) PR
10 20 30 40 50 60
MVGTWFLCRG FTTLAGLLLL PFGSLAASQI EDQAEQFFRS GHTNNWAVLV CTSRFWFNYR
70 80 90 100 110 120
HVANTLSVYR SVKRLGIPDS HIVLMLADDM ACNPRNPKPA TVYSHKNMEL NVYGDDVEVD
130 140 150 160 170 180
YRSYVVTVEN FLRVLTGRIP PSTPRSKRLL SDDRSNILIY MTGHGGNGFL KFQDSEEITN
190 200 210 220 230 240
IELADAFEQM WQKRRYNELL FIIDTCQGAS MYERFYSPNI MALASSQVGE DSLSHQPDPA
250 260 270 280 290 300
IGVHLMDRYT FYVLEFLEEI NPASQTNMND LFQVCPKSLC VSTPGHRTDP FQRDPKHVLI
310 320 330 340 350 360
TDFFGSVRKV EITTETISLQ PDSGIMKSSH EKAGMDEELM EPLKYAEQLP VAQIIHQKPK
370 380 390
LKDWHPPGGF ILGLWALIIM VFFKTYGIKH MKFIF