AiPD: Autoinhibited Protein Database

Gene name	PIGK
Protein name	GPI-anchor transamidase
Names	GPI transamidase, Phosphatidylinositol-glycan biosynthesis class K protein, PIG-K
Species	Bos taurus (Bovine)
KEGG Pathway	bta:508700
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

289-367 (Predicted disordered autoinhibitory region) PR

289-367 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q3MHZ7-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs379960599	4	T>I	No	EVA
rs718006499	6	F>L	No	EVA
rs383719733	9	R>P	No	EVA
rs383719733	9	R>Q	No	EVA
rs3423649933	60	R>Q	No	EVA
rs448274254	127	T>N	No	EVA
rs468273355	129	E>D	No	EVA
rs433262106	156	N>H	No	EVA
rs453381390	157	I>L	No	EVA
rs451347431	190	M>I	No	EVA
rs476395298	235	H>N	No	EVA
rs438551519	236	Q>H	No	EVA
rs441206758	255	E>A	No	EVA
rs461176638	269	N>K	No	EVA
rs481795075	270	D>Y	No	EVA
rs133339335	277	R>K	No	EVA
rs439221456	331	K>*	No	EVA
rs439221456	331	K>E	No	EVA
rs439221456	331	K>Q	No	EVA
rs459256846	331	K>R	No	EVA
rs459256846	331	K>T	No	EVA
rs473377278	332	K>I	No	EVA
rs441882724	332	K>N	No	EVA
rs461998184	333	D>Y	No	EVA
rs482017058	337	E>Q	No	EVA
rs450688314	341	E>*	No	EVA
rs478333620	353	Q>*	No	EVA
rs446888976	355	I>V	No	EVA
rs1115615710	357	Q>K	No	EVA

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for Q3MHZ7

		Description
EC Number
Subcellular Localization	Endoplasmic reticulum membrane ; Single-pass type I membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
GPI-anchor transamidase complex	An enzyme complex which in humans and yeast consists of at least five proteins; for example, the complex contains GAA1, GPI8, PIG-S, PIG-U, and PIG-T in human, and Gaa1p, Gab1p, Gpi8p, Gpi16p, and Gpi17p in yeast. Catalyzes the posttranslational attachment of the carboxy-terminus of a precursor protein to a GPI-anchor.

Name	Definition
GPI-anchor transamidase activity	Catalysis of the formation of the linkage between a protein and a glycosylphosphatidylinositol anchor. The reaction probably occurs by subjecting a peptide bond to nucleophilic attack by the amino group of ethanolamine-GPI, transferring the protein from a signal peptide to the GPI anchor.

Name	Definition
attachment of GPI anchor to protein	A transamidation reaction that results in the cleavage of the polypeptide chain and the concomitant transfer of the GPI anchor to the newly formed carboxy-terminal amino acid of the anchored protein. The cleaved C-terminal contains the C-terminal GPI signal sequence of the newly synthesized polypeptide chain.
protein localization to cell surface	A process in which a protein is transported to, or maintained in, a location within the external part of the cell wall and/or plasma membrane.
proteolysis	The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q92643	PIGK	GPI-anchor transamidase	Homo sapiens (Human)	PR
Q9CXY9	Pigk	GPI-anchor transamidase	Mus musculus (Mouse)	PR
Q4KRV1	PIGK	GPI-anchor transamidase	Sus scrofa (Pig)	PR