AiPD: Autoinhibited Protein Database

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

1-69 (Predicted disordered autoinhibitory region) PR

1-69 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q9CQV4-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs3389178224	54	S>N	No	EVA
rs3389178249	55	R>L	No	EVA
rs3389141016	69	A>V	No	EVA
rs3389207172	117	P>Q	No	EVA
rs3389214034	150	S>G	No	EVA
rs3389197062	158	L>P	No	EVA
rs3389178242	237	K>N	No	EVA
rs226735331	254	T>M	No	EVA
rs3389211585	312	G>S	No	EVA
rs3402705831	317	D>A	No	EVA
rs3389204414	318	G>A	No	EVA
rs3402034297	335	S>Y	No	EVA
rs3402817689	337	N>K	No	EVA
rs3402072756	338	V>L	No	EVA
rs3389211642	340	P>H	No	EVA
rs3389197021	373	S>G	No	EVA
rs3389138136	382	L>F	No	EVA
rs3389214007	404	G>D	No	EVA
rs3389197087	405	M>I	No	EVA
rs3402869858	416	T>P	No	EVA
rs13473314	425	R>I	No	EVA
rs3389138205	432	R>W	No	EVA

Type	Name	Position	InterPro Accession
domain	Ribonuclease H2 subunit B, wHTH domain	95 - 228	IPR019024
domain	Rnh202, triple barrel domain	33 - 92	IPR041195

		Description
EC Number
Subcellular Localization	Endoplasmic reticulum membrane ; Multi-pass membrane protein	Localizes preferentially to endoplasmic reticulum tubules and sheet edges
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
endoplasmic reticulum	The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
integral component of membrane	The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
protein-containing complex	A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.

Name	Definition
endoplasmic reticulum-autophagosome adaptor activity	The binding activity of a molecule that brings together an ER membrane and an autophagosome during reticulophagy.

Name	Definition
collagen catabolic process	The proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix, usually carried out by proteases secreted by nearby cells.
endoplasmic reticulum organization	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endoplasmic reticulum.
positive regulation of neuron projection development	Any process that increases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
reticulophagy	The selective autohagy process in which parts of the endoplasmic reticulum are loaded into autophagosomes, delivered to the vacuole, and degraded in response to changing cellular conditions.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q5E9K8	RETREG1	Reticulophagy regulator 1	Bos taurus (Bovine)	PR
Q9H6L5	RETREG1	Reticulophagy regulator 1	Homo sapiens (Human)	PR
Q86VR2	RETREG3	Reticulophagy regulator 3	Homo sapiens (Human)	PR
Q6NS82	Retreg2	Reticulophagy regulator 2	Mus musculus (Mouse)	PR
Q8VE91	Retreg1	Reticulophagy regulator 1	Mus musculus (Mouse)	PR
Q0P4Z1	retreg3	Reticulophagy regulator 3	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	PR