Q6NS82
Gene name |
Retreg2 (Fam134a) |
Protein name |
Reticulophagy regulator 2 |
Names |
|
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:227298 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q6NS82
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q6NS82-F1 | Predicted | AlphaFoldDB |
22 variants for Q6NS82
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388478488 | 91 | L>M | No | EVA | |
| rs3388479413 | 98 | P>L | No | EVA | |
| rs3388478404 | 130 | E>A | No | EVA | |
| rs3388479122 | 130 | E>D | No | EVA | |
| rs585370589 | 185 | G>V | No | EVA | |
| rs263519159 | 187 | A>S | No | EVA | |
| rs224418164 | 188 | A>G | No | EVA | |
| rs251647838 | 191 | V>M | No | EVA | |
| rs237292059 | 202 | V>I | No | EVA | |
| rs3388478204 | 218 | V>E | No | EVA | |
| rs3388479409 | 228 | Y>F | No | EVA | |
| rs3388479316 | 330 | D>E | No | EVA | |
| rs3388478224 | 331 | V>F | No | EVA | |
| rs3388480629 | 360 | L>Q | No | EVA | |
| rs248233565 | 384 | G>A | No | EVA | |
| rs224152268 | 390 | A>T | No | EVA | |
| rs242058132 | 421 | A>G | No | EVA | |
| rs3388478824 | 444 | P>S | No | EVA | |
| rs3388478815 | 457 | L>H | No | EVA | |
| rs255960461 | 458 | S>F | No | EVA | |
| rs3388479463 | 482 | L>H | No | EVA | |
| rs3388479127 | 501 | E>* | No | EVA |
No associated diseases with Q6NS82
No regional properties for Q6NS82
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q6NS82 | |||
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| endoplasmic reticulum | The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| endoplasmic reticulum-autophagosome adaptor activity | The binding activity of a molecule that brings together an ER membrane and an autophagosome during reticulophagy. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| collagen catabolic process | The proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix, usually carried out by proteases secreted by nearby cells. |
| endoplasmic reticulum organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endoplasmic reticulum. |
| reticulophagy | The selective autohagy process in which parts of the endoplasmic reticulum are loaded into autophagosomes, delivered to the vacuole, and degraded in response to changing cellular conditions. |
5 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q5E9K8 | RETREG1 | Reticulophagy regulator 1 | Bos taurus (Bovine) | PR |
| Q86VR2 | RETREG3 | Reticulophagy regulator 3 | Homo sapiens (Human) | PR |
| Q9H6L5 | RETREG1 | Reticulophagy regulator 1 | Homo sapiens (Human) | PR |
| Q9CQV4 | Retreg3 | Reticulophagy regulator 3 | Mus musculus (Mouse) | PR |
| Q0P4Z1 | retreg3 | Reticulophagy regulator 3 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MASSGGGNTG | AGGTSGLGLG | LGLSLGMGEA | TGDAEEEAAA | AEAVGRLATS | LWLRLRGWEA |
| 70 | 80 | 90 | 100 | 110 | 120 |
| VLAAAQRLLV | WEKPLHSLVT | AATLNGLFWL | LSSSSLRPFF | LLSISLLTYF | LLDLWHPRFL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| PDVSAPPPEE | PHSDSEGAGS | GAQPHLLSVP | ELCRYLAESW | LTFQIHLQEL | LQYKRQNPAQ |
| 190 | 200 | 210 | 220 | 230 | 240 |
| FCARGCAACA | VLAVLGHYVP | GVMISYIVLL | SILLWPLVVY | HELIQRMYTR | LEPLLMQLDY |
| 250 | 260 | 270 | 280 | 290 | 300 |
| SMKAEADALH | HKHDKRKRQG | KSAPPAGDEP | LAETESESEA | ELAGFSPVVD | VKKTALALAI |
| 310 | 320 | 330 | 340 | 350 | 360 |
| TDSELSDEEA | SILESGGFSV | SRATTPQLTD | VSEDLDQQSL | PSEPEEALNR | ELGEGEETEL |
| 370 | 380 | 390 | 400 | 410 | 420 |
| ASPEDLLSAP | PALSKQALDT | EEEGAADKEA | LLQLSSPLHF | VNTHFNGAGS | PQDGVKCPPG |
| 430 | 440 | 450 | 460 | 470 | 480 |
| APVKTLSPEA | VSGDLMAPSS | TLSPQLCLAE | SGPVTPLSPS | VLPSLPQDSP | QPLAAPEEEE |
| 490 | 500 | 510 | 520 | 530 | 540 |
| ALTTEDFELL | DQGELEQLNA | ELGLGPEMPP | KPPDVLPPPP | LGADSHSLVQ | SDQEAHAEVE |
| P |