Q5E9K8

PR
Gene name
RETREG1 (FAM134B)
Protein name
Reticulophagy regulator 1
Names
Reticulophagy receptor 1
Species
Bos taurus (Bovine)
KEGG Pathway
bta:540068
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-82 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5E9K8

Entry ID Method Resolution Chain Position Source
AF-Q5E9K8-F1 Predicted AlphaFoldDB

No variants for Q5E9K8

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5E9K8

No associated diseases with Q5E9K8

No regional properties for Q5E9K8

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q5E9K8

Functions

Description
EC Number
Subcellular Localization
  • Golgi apparatus, cis-Golgi network membrane ; Multi-pass membrane protein
  • Endoplasmic reticulum membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cis-Golgi network The network of interconnected tubular and cisternal structures located at the convex side of the Golgi apparatus, which abuts the endoplasmic reticulum.
integral component of endoplasmic reticulum membrane The component of the endoplasmic reticulum membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

3 GO annotations of biological process

Name Definition
negative regulation of neuron apoptotic process Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process in neurons.
reticulophagy The selective autohagy process in which parts of the endoplasmic reticulum are loaded into autophagosomes, delivered to the vacuole, and degraded in response to changing cellular conditions.
sensory perception of pain The series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal. Pain is medically defined as the physical sensation of discomfort or distress caused by injury or illness, so can hence be described as a harmful stimulus which signals current (or impending) tissue damage. Pain may come from extremes of temperature, mechanical damage, electricity or from noxious chemical substances. This is a neurological process.

6 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q86VR2 RETREG3 Reticulophagy regulator 3 Homo sapiens (Human) PR
Q9H6L5 RETREG1 Reticulophagy regulator 1 Homo sapiens (Human) PR
Q6NS82 Retreg2 Reticulophagy regulator 2 Mus musculus (Mouse) PR
Q8VE91 Retreg1 Reticulophagy regulator 1 Mus musculus (Mouse) PR
Q9CQV4 Retreg3 Reticulophagy regulator 3 Mus musculus (Mouse) PR
Q5FVM3 Retreg1 Reticulophagy regulator 1 Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MASPAPPEPA EQGSPALAAA PQAPPPPTRA PPEEPEGAAP PEEGAAAGAG RQVEEAAGGV
70 80 90 100 110 120
AAVVTWLLGE PALWLGGRAD ELLSWKRPLH SLLAFVGANL VFWFLALTPW RVYHLISVMI
130 140 150 160 170 180
LTRVIMQIIK DMILSRTRGA QLWRSLSESW EVINSKPDER PGFSHCLAES WMNFSIFLQE
190 200 210 220 230 240
MSVFKQQSPG KFCLLVCSVC TFFTILGSYI PGVILSYLLL LCAFLCPLFK CNDIGQKIYS
250 260 270 280 290 300
KIKSCLLKLD FGIREYINQK KRERSEADKE KSHKDDSELD FSALCPKISL TTAAKELSVS
310 320 330 340 350 360
DTDVSEVSWT DNGTFNLSEG YTPQTDTSDD LDRPSEEVFS RDLSDFPSLE NGTGTNDEDE
370 380 390 400 410 420
LSLGLPTELK RKKEQLDGGP RRSTEKKSAA GLSLPLSSDQ TLHLMSDLAG DVITAAVTAA
430 440 450 460 470 480
VKDQLAGVRQ ALSQAAPSLG EDTDTEEGDD FELLDQSELD QIESELGLSQ DQEAEAQQNK
490
KSSGFLSNLL GGH