AiPD: Autoinhibited Protein Database

Q9BVW5

Gene name	TIPIN
Protein name	TIMELESS-interacting protein
Names
Species	Homo sapiens (Human)
KEGG Pathway	hsa:54962
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

157-273 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

157-273 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

4 structures for Q9BVW5

Entry ID	Method	Resolution	Chain	Position	Source
7PFO	EM	320 A	L	1-301	PDB
7PLO	EM	280 A	L	1-301	PDB
8B9D	EM	340 A	L	1-301	PDB
AF-Q9BVW5-F1	Predicted				AlphaFoldDB

234 variants for Q9BVW5

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs565441627 CA7623827	2	L>I		No	ClinGen 1000Genomes ExAC gnomAD
CA7623826 rs762481231	4	P>L		No	ClinGen ExAC gnomAD
rs748747093 CA271654683	7	N>D		No	ClinGen Ensembl
rs764985464 CA7623824	8	G>S		No	ClinGen ExAC TOPMed gnomAD
CA7623822 rs573461004	9	V>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
CA392942576 rs1427220808	10	I>T		No	ClinGen gnomAD
rs138329708 CA7623821	12	L>P		No	ClinGen ESP ExAC TOPMed gnomAD
CA392942563 rs138329708	12	L>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA7623820 rs760704351	13	P>S		No	ClinGen ExAC gnomAD
CA7623819 rs775504121	14	D>N		No	ClinGen ExAC gnomAD
CA7623818 rs772077095	14	D>V		No	ClinGen ExAC TOPMed gnomAD
CA392942528 rs1566977398	17	H>Q		No	ClinGen Ensembl
CA392942531 rs1413244752	17	H>R		No	ClinGen TOPMed
rs774275285 CA7623816	18	V>I		No	ClinGen ExAC gnomAD
CA7623814 rs749497501 CA392942518	19	E>D		No	ClinGen ExAC TOPMed gnomAD
CA7623815 rs771225491	19	E>G		No	ClinGen ExAC TOPMed gnomAD
rs371297618 CA271654652	19	E>Q		No	ClinGen ESP TOPMed
rs1595799497 CA392942501	22	T>P		No	ClinGen Ensembl
CA271654642 rs201530827	23	F>S		No	ClinGen 1000Genomes
rs1314440345 CA392942484	24	P>L		No	ClinGen gnomAD
rs756403375 CA7623812	24	P>S		No	ClinGen ExAC gnomAD
TCGA novel rs748683752 CA7623811	26	F>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA ClinGen ExAC gnomAD
CA392942468 rs1307939967	27	P>S		No	ClinGen gnomAD
TCGA novel	27	P>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs200999398 CA7623809	28	P>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs1595799412 CA392942454	29	P>L		No	ClinGen Ensembl
TCGA novel	29	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA7623806 rs757031264	30	A>P		No	ClinGen ExAC TOPMed gnomAD
rs757031264 CA271654610	30	A>S		No	ClinGen ExAC TOPMed gnomAD
CA7623807 rs757031264	30	A>T		No	ClinGen ExAC TOPMed gnomAD
CA392942451 rs1167209794	30	A>V		No	ClinGen gnomAD
CA7623805 rs150893823	31	S>F		No	ClinGen ESP ExAC
CA392942439 rs1475383244	33	E>K		No	ClinGen gnomAD
CA392942430 rs1355097050	34	R>G		No	ClinGen TOPMed
rs375749313 CA7623804	35	Q>*		No	ClinGen ESP ExAC TOPMed gnomAD
rs375749313 CA7623803	35	Q>K		No	ClinGen ESP ExAC TOPMed gnomAD
CA392942414 rs1484033481	36	D>G		No	ClinGen TOPMed gnomAD
rs1484033481 CA392942413	36	D>V		No	ClinGen TOPMed gnomAD
rs141529487 CA7623802	37	G>C		No	ClinGen ESP ExAC TOPMed gnomAD
rs767540271 CA7623801	37	G>D		No	ClinGen ExAC gnomAD
CA392942410 rs141529487	37	G>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA392942400 rs11538105	38	E>D		No	ClinGen gnomAD
CA392942406 rs1190271765	38	E>K		No	ClinGen TOPMed gnomAD
rs1465563620 CA392942388	40	T>S		No	ClinGen gnomAD
rs770856816 CA7623798	42	P>S		No	ClinGen ExAC TOPMed gnomAD
rs770163296 CA7623795	44	E>A		No	ClinGen ExAC TOPMed gnomAD
CA392942357 rs781378167	45	E>*		No	ClinGen ExAC gnomAD
COSM1493460 rs781378167 CA7623793	45	E>K	kidney Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
rs770038398 CA7623776	46	S>A		No	ClinGen ExAC gnomAD
rs1176444497 CA392942308	50	A>G		No	ClinGen TOPMed
TCGA novel	52	V>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs762015200 CA7623775	52	V>I		No	ClinGen ExAC TOPMed gnomAD
rs9806123 CA392942292	53	R>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs9806123 CA7623774 VAR_035194	53	R>P		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs1161756891 CA392942291	54	V>I		No	ClinGen TOPMed
rs115121189 CA7623772	55	P>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
TCGA novel	57	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1393182763 CA392942228	63	N>S		No	ClinGen gnomAD
CA392942221 rs1444800412	64	I>T		No	ClinGen TOPMed
rs777386587 CA7623768	64	I>V		No	ClinGen ExAC gnomAD
rs755899670 CA7623767	65	P>L		No	ClinGen ExAC TOPMed gnomAD
rs752232000 CA7623766	66	K>E		No	ClinGen ExAC TOPMed gnomAD
rs1343563871 CA392942211	66	K>R		No	ClinGen gnomAD
TCGA novel	70	Q>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs754689583 CA7623764	70	Q>P		No	ClinGen ExAC gnomAD
TCGA novel	71	R>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA392941963 rs1357155929	72	L>F		No	ClinGen gnomAD
rs1409175009 CA392941931	75	E>K		No	ClinGen gnomAD
CA7623716 rs566108118	76	R>G		No	ClinGen 1000Genomes ExAC gnomAD
rs758385810 CA7623715	76	R>K		No	ClinGen ExAC gnomAD
CA392941845 rs1161119644	81	L>*		No	ClinGen gnomAD
CA392941849 rs1412536020	81	L>V		No	ClinGen gnomAD
CA7623714 rs375119775	82	R>K		No	ClinGen ESP ExAC TOPMed gnomAD
CA7623713 rs765309272	87	K>N		No	ClinGen ExAC gnomAD
CA392941767 rs1268020981	88	A>T		No	ClinGen TOPMed
CA7623712 rs761762353	89	K>E		No	ClinGen ExAC gnomAD
CA392941701 rs1483050451	92	G>A		No	ClinGen gnomAD
CA271653959 rs373239549	93	K>*		No	ClinGen ESP ExAC TOPMed gnomAD
CA7623711 rs373239549	93	K>E		No	ClinGen ESP ExAC TOPMed gnomAD
rs1206635908 CA392941690	93	K>N		No	ClinGen gnomAD
rs1289358965 CA392941682	94	G>D		No	ClinGen gnomAD
CA7623710 rs549576831	94	G>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs760920977	96	E>=	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs760920977 CA392941657	96	E>D		No	ClinGen ExAC gnomAD
rs1226866204 CA392941667	96	E>K		No	ClinGen gnomAD
rs1156973271 CA392941334	98	E>Q		No	ClinGen TOPMed
TCGA novel	101	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA7623695 rs758125707	102	M>V		No	ClinGen ExAC TOPMed gnomAD
CA7623693 rs148813972	104	I>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs569410680 CA7623691	106	H>N		No	ClinGen 1000Genomes ExAC gnomAD
TCGA novel	106	H>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA271652800 rs201114661	106	H>Q		No	ClinGen 1000Genomes
CA7623690 rs145644256	107	M>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs752911952 CA7623688	109	H>R		No	ClinGen ExAC gnomAD
rs2063690 CA7623686	111	A>E		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA7623684 VAR_035195 rs2063690	111	A>G		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA392941184 rs1566975341	111	A>P		No	ClinGen Ensembl
rs2063690 CA7623685	111	A>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA392941179 rs1442483261	112	H>Y		No	ClinGen gnomAD
CA271652722 rs563205164	113	R>G		No	ClinGen Ensembl
CA392941163 rs1319512793	113	R>K		No	ClinGen gnomAD
TCGA novel	116	P>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs778074456 CA271652706	118	L>R		No	ClinGen Ensembl
rs11538107 CA271652705	119	Q>*		No	ClinGen Ensembl
CA392941097 rs768151887	121	E>K		No	ClinGen ExAC TOPMed gnomAD
CA7623680 rs768151887	121	E>Q		No	ClinGen ExAC TOPMed gnomAD
CA392941090 rs1420271380	122	D>N		No	ClinGen gnomAD
rs1424531379 CA392941054	126	R>S		No	ClinGen gnomAD
TCGA novel	127	V>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA7623677 rs775086729	131	G>R		No	ClinGen ExAC TOPMed gnomAD
rs190019854 CA7623676	132	S>N		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1484753180 CA392941010	133	K>T		No	ClinGen gnomAD
CA271652435 rs755062992	139	C>Y		No	ClinGen gnomAD
CA7623657 rs774962377	140	L>V		No	ClinGen ExAC gnomAD
CA7623656 rs771755903	142	R>*		No	ClinGen ExAC TOPMed gnomAD
COSM3420544 rs76072153 CA392940914	142	R>L	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
CA7623655 rs76072153 COSM258183	142	R>Q	Variant assessed as Somatic; 9.254e-05 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
COSM964219 rs774073117 CA7623654	144	R>*	endometrium Variant assessed as Somatic; 4.626e-05 impact. breast [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA271652400 rs774073117	144	R>G		No	ClinGen ExAC TOPMed gnomAD
CA392940905 rs770703850	144	R>L		No	ClinGen ExAC gnomAD
CA7623653 rs770703850	144	R>Q		No	ClinGen ExAC gnomAD
rs1365027835 CA392940900	145	L>P		No	ClinGen TOPMed
CA7623652 rs200514985	146	D>G		No	ClinGen ESP ExAC TOPMed gnomAD
rs1595794362 CA392940876	149	I>T		No	ClinGen Ensembl
rs140845772 CA271652373	149	I>V		No	ClinGen ESP TOPMed gnomAD
rs76604393 CA271652368	151	H>P		No	ClinGen Ensembl
rs748277714 CA7623649	154	F>I		No	ClinGen ExAC gnomAD
rs77256183 CA271652347	155	V>I		No	ClinGen TOPMed gnomAD
CA392940822 rs1274467117	157	N>D		No	ClinGen TOPMed
rs1292506661 CA392940522	159	D>G		No	ClinGen gnomAD
CA7623575 rs753754622	161	V>I		No	ClinGen ExAC gnomAD
rs1357220802 CA392940500	162	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA7623573 rs760674828	164	N>K		No	ClinGen ExAC TOPMed gnomAD
CA392940483 rs1440774356	165	N>D		No	ClinGen gnomAD
CA7623572 rs752514038	165	N>K		No	ClinGen ExAC gnomAD
CA392940476 rs1432070246	166	E>K		No	ClinGen TOPMed
rs759488177 CA7623569	170	T>A		No	ClinGen ExAC gnomAD
CA271647681 rs868643762	171	S>Y		No	ClinGen Ensembl
rs1420587772 CA392940415	175	D>Y		No	ClinGen gnomAD
CA271647653 rs956802987	178	L>P		No	ClinGen TOPMed gnomAD
rs539879797 CA7623566	180	N>H		No	ClinGen 1000Genomes ExAC gnomAD
TCGA novel	182	S>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1206869335 CA392940366	182	S>F		No	ClinGen gnomAD
rs144764364 CA7623564	182	S>P		No	ClinGen ESP ExAC TOPMed gnomAD
CA7623563 rs769981626	184	S>R		No	ClinGen ExAC gnomAD
rs1272794615 CA392940340	186	M>L		No	ClinGen gnomAD
CA392940316 rs1211551137	189	S>Y		No	ClinGen gnomAD
rs574183014 CA392940295	192	S>I		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs574183014 CA7623561	192	S>N		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs574183014 CA7623562	192	S>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA392940254 rs1293812704	198	E>G		No	ClinGen gnomAD
TCGA novel	198	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA7623560 rs769182311	199	Q>H		No	ClinGen ExAC gnomAD
CA7623559 rs745413570	201	Q>*		No	ClinGen ExAC gnomAD
rs1344606843 CA392940223	202	R>S		No	ClinGen TOPMed
TCGA novel	203	I>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA392940217 rs1216062785	203	I>T		No	ClinGen TOPMed
CA392940195 rs1287480698	206	N>S		No	ClinGen TOPMed
rs757029201 CA7623557	211	L>V		No	ClinGen ExAC gnomAD
rs753483864 CA7623556	212	E>G		No	ClinGen ExAC gnomAD
rs1595784327 CA392940135	215	Q>*		No	ClinGen Ensembl
CA7623555 rs777632768	215	Q>R		No	ClinGen ExAC gnomAD
rs1397190999 CA392940107	219	L>R		No	ClinGen gnomAD
rs1400694852 CA392940103	220	S>N		No	ClinGen gnomAD
rs1222294098 CA392940097	221	N>D		No	ClinGen TOPMed
rs767406170 CA7623552	222	S>I		No	ClinGen ExAC gnomAD
rs759463833 CA7623551	225	L>P		No	ClinGen ExAC gnomAD
CA7623550 rs751692954	226	G>*		No	ClinGen ExAC TOPMed gnomAD
CA392940060 rs1248208786	227	N>H		No	ClinGen TOPMed
CA7623535 rs747936027	229	M>T		No	ClinGen ExAC TOPMed gnomAD
CA7623534 rs781026068	231	M>T		No	ClinGen ExAC TOPMed gnomAD
CA7623533 rs754919776	232	N>D		No	ClinGen ExAC gnomAD
rs751428475 CA7623532	233	T>I		No	ClinGen ExAC TOPMed gnomAD
rs1360379047 CA392940002	233	T>P		No	ClinGen gnomAD
CA392939996 rs1374914584	234	P>A		No	ClinGen gnomAD
CA392939995 rs1374914584	234	P>S		No	ClinGen gnomAD
rs758424468 CA7623530	236	A>E		No	ClinGen ExAC gnomAD
CA7623529 rs750492896	238	T>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs750492896 CA392939967	238	T>R		No	ClinGen ExAC gnomAD
rs1054843997 CA271645217	239	V>L		No	ClinGen TOPMed gnomAD
rs1400695441 CA392939958	240	E>A		No	ClinGen TOPMed
rs1566968910 CA392939946	241	E>D		No	ClinGen Ensembl
rs1566968921 CA392939949	241	E>G		No	ClinGen Ensembl
CA7623526 rs369278653	243	N>I		No	ClinGen ESP ExAC TOPMed gnomAD
rs1382940486 CA392939927	244	T>I		No	ClinGen gnomAD
CA392939921 rs1485269391	245	D>V		No	ClinGen gnomAD
CA7623524 rs575302613	249	K>E		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA392939879 rs1483305950	251	E>*		No	ClinGen gnomAD
CA392939876 rs1250395853	251	E>A		No	ClinGen TOPMed gnomAD
CA392939875 rs1250395853	251	E>G		No	ClinGen TOPMed gnomAD
rs1483305950 CA392939877	251	E>K		No	ClinGen gnomAD
CA271645144 rs528422551	255	L>*		No	ClinGen 1000Genomes
COSM3816608 rs1219650817 CA392939837	257	E>K	Variant assessed as Somatic; 0.0 impact. breast [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
CA271645120 rs748858524	259	I>F		No	ClinGen ExAC TOPMed gnomAD
CA7623519 rs748858524	259	I>V		No	ClinGen ExAC TOPMed gnomAD
CA7623518 rs3759787 VAR_053952 COSM147946	260	L>P	stomach [Cosmic]	No	ClinGen cosmic curated UniProt 1000Genomes ExAC TOPMed dbSNP gnomAD
rs769387299 CA7623517	262	N>I		No	ClinGen ExAC gnomAD
rs756153537 CA7623515	264	C>*		No	ClinGen ExAC gnomAD
CA7623516 rs747775116	264	C>R		No	ClinGen ExAC gnomAD
CA392939787 rs1297816223	264	C>Y		No	ClinGen gnomAD
CA392939782 rs1566968772	265	N>Y		No	ClinGen Ensembl
VAR_035196 CA7623514 rs3759786	267	A>S		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA7623513 rs754724009	268	I>T		No	ClinGen ExAC gnomAD
rs201269482 CA271645092	269	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs34848112 CA7623512 VAR_062207	270	N>D		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs34848112 CA271645083	270	N>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs780014564 VAR_054483 CA7623511	270	N>S		No	ClinGen UniProt ExAC TOPMed dbSNP gnomAD
CA271645075 rs28533152	272	L>F		No	ClinGen Ensembl
rs758299521 CA7623510	272	L>V		No	ClinGen ExAC TOPMed gnomAD
rs1249291973 CA392939712	276	E>K		No	ClinGen gnomAD
rs111901689 CA271645064	277	T>A		No	ClinGen Ensembl
CA392939692 rs1481378193	279	L>Q		No	ClinGen gnomAD
CA271645061 rs376496781	280	D>E		No	ClinGen ESP
rs750533050 CA7623509	280	D>H		No	ClinGen ExAC gnomAD
CA392939682 rs765347481	281	Q>*		No	ClinGen ExAC TOPMed gnomAD
CA7623508 rs765347481	281	Q>K		No	ClinGen ExAC TOPMed gnomAD
CA7623507 rs201129710	283	F>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs754026817 CA7623506	286	V>M		No	ClinGen ExAC gnomAD
rs764585172 CA7623505	288	Q>R		No	ClinGen ExAC gnomAD
rs775978283 CA271645035	289	Q>*		No	ClinGen ExAC TOPMed gnomAD
rs775978283 CA7623503	289	Q>K		No	ClinGen ExAC TOPMed gnomAD
CA7623502 rs768182185	290	L>F		No	ClinGen ExAC TOPMed gnomAD
rs1379340789 CA392939618	290	L>P		No	ClinGen gnomAD
rs1352961437 CA392939616	291	D>N		No	ClinGen TOPMed
TCGA novel	292	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA7623500 rs148498973	294	S>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA271645023 rs922506490	294	S>P		No	ClinGen TOPMed
CA392939592 rs1199467954	295	R>G		No	ClinGen TOPMed
CA7623499 rs769278333	297	I>T		No	ClinGen ExAC gnomAD
rs1167008776 CA392939576	297	I>V		No	ClinGen gnomAD
rs372313875 CA271645014	298	T>P		No	ClinGen Ensembl
CA392939565 rs1363170873	299	E>K		No	ClinGen gnomAD
TCGA novel	300	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA271644995 rs952008036	302	R>Y		No	ClinGen Ensembl

No associated diseases with Q9BVW5

No regional properties for Q9BVW5

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for Q9BVW5

Functions

		Description
EC Number
Subcellular Localization	Cytoplasm Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

5 GO annotations of cellular component

Name	Definition
chromatin	The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome.
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
replication fork protection complex	A protein complex conserved in eukaryotes and associated with the replication fork; the complex stabilizes stalled replication forks and is thought to be involved in coordinating leading- and lagging-strand synthesis and in replication checkpoint signaling.

1 GO annotations of molecular function

Name	Definition
DNA binding	Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

9 GO annotations of biological process

Name	Definition
cell cycle phase transition	The cell cycle process by which a cell commits to entering the next cell cycle phase.
cell division	The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.
DNA replication checkpoint signaling	A signal transduction process that contributes to a DNA replication checkpoint, that prevents the initiation of nuclear division until DNA replication is complete, thereby ensuring that progeny inherit a full complement of the genome.
mitotic intra-S DNA damage checkpoint signaling	A mitotic cell cycle checkpoint that slows DNA synthesis in response to DNA damage by the prevention of new origin firing and the stabilization of slow replication fork progression.
positive regulation of cell population proliferation	Any process that activates or increases the rate or extent of cell proliferation.
regulation of nuclear cell cycle DNA replication	Any process that modulates the frequency, rate or extent of The DNA-dependent DNA replication that occurs in the nucleus of eukaryotic organisms as part of the cell cycle.
replication fork arrest	Any process that stops, prevents, or reduces the frequency, rate or extent of DNA replication by impeding the progress of the DNA replication fork. Replication fork arrest is one of the 'quality control' processes ensuring that DNA-dependent DNA replication occurs correctly. DNA replication fork arrest during DNA-dependent DNA replication is not known to occur outside of cases where a replication error needs to be prevented or corrected.
replication fork protection	Any process that prevents the collapse of stalled replication forks.
response to UV	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultraviolet radiation (UV light) stimulus. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers.

3 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q04659	CSM3	Chromosome segregation in meiosis protein 3	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	PR
Q5F416	TIPIN	TIMELESS-interacting protein	Gallus gallus (Chicken)	PR
Q6DBR4	tipin	TIMELESS-interacting protein	Danio rerio (Zebrafish) (Brachydanio rerio)	PR

10	20	30	40	50	60
MLEPQENGVI	DLPDYEHVED	ETFPPFPPPA	SPERQDGEGT	EPDEESGNGA	PVRVPPKRTV
70	80	90	100	110	120
KRNIPKLDAQ	RLISERGLPA	LRHVFDKAKF	KGKGHEAEDL	KMLIRHMEHW	AHRLFPKLQF
130	140	150	160	170	180
EDFIDRVEYL	GSKKEVQTCL	KRIRLDLPIL	HEDFVSNNDE	VAENNEHDVT	STELDPFLTN
190	200	210	220	230	240
LSESEMFASE	LSRSLTEEQQ	QRIERNKQLA	LERRQAKLLS	NSQTLGNDML	MNTPRAHTVE
250	260	270	280	290	300
EVNTDEDQKE	ESNGLNEDIL	DNPCNDAIAN	TLNEEETLLD	QSFKNVQQQL	DATSRNITEA

R