Q04659
Gene name |
CSM3 (YMR048W, YM9796.01) |
Protein name |
Chromosome segregation in meiosis protein 3 |
Names |
|
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YMR048W |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
9 structures for Q04659
10 variants for Q04659
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s13-367197 | 73 | H>R | No | SGRP | |
| s13-367506 | 176 | F>S | No | SGRP | |
| s13-367521 | 181 | R>M | No | SGRP | |
| s13-367599 | 207 | R>Q | No | SGRP | |
| s13-367605 | 209 | L>* | No | SGRP | |
| s13-367607 | 210 | D>H | No | SGRP | |
| s13-367635 | 219 | L>P | No | SGRP | |
| s13-367661 | 228 | D>N | No | SGRP | |
| s13-367809 | 277 | S>N | No | SGRP | |
| s13-367844 | 289 | Q>K | No | SGRP |
No associated diseases with Q04659
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| nuclear replication fork | The Y-shaped region of a nuclear replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| replication fork protection complex | A protein complex conserved in eukaryotes and associated with the replication fork; the complex stabilizes stalled replication forks and is thought to be involved in coordinating leading- and lagging-strand synthesis and in replication checkpoint signaling. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| DNA binding | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). |
8 GO annotations of biological process
| Name | Definition |
|---|---|
| DNA repair | The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. |
| DNA replication checkpoint signaling | A signal transduction process that contributes to a DNA replication checkpoint, that prevents the initiation of nuclear division until DNA replication is complete, thereby ensuring that progeny inherit a full complement of the genome. |
| establishment of mitotic sister chromatid cohesion | The process in which the sister chromatids of a replicated chromosome become joined along the entire length of the chromosome during S phase during a mitotic cell cycle. |
| maintenance of DNA repeat elements | Any process involved in sustaining the fidelity and copy number of DNA repeat elements. |
| meiotic chromosome segregation | The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets during M phase of the meiotic cell cycle. |
| mitotic sister chromatid cohesion | The cell cycle process in which the sister chromatids of a replicated chromosome are joined along the entire length of the chromosome, from their formation in S phase through metaphase during a mitotic cell cycle. This cohesion cycle is critical for high fidelity chromosome transmission. |
| replication fork arrest | Any process that stops, prevents, or reduces the frequency, rate or extent of DNA replication by impeding the progress of the DNA replication fork. Replication fork arrest is one of the 'quality control' processes ensuring that DNA-dependent DNA replication occurs correctly. DNA replication fork arrest during DNA-dependent DNA replication is not known to occur outside of cases where a replication error needs to be prevented or corrected. |
| replication fork protection | Any process that prevents the collapse of stalled replication forks. |
3 homologous proteins in AiPD
| 10 | 20 | 30 | 40 | 50 | 60 |
| MDQDFDSLLL | GFNDSDSVQK | DPTVPNGLDG | SVVDPTIADP | TAITARKRRP | QVKLTAEKLL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| SDKGLPYVLK | NAHKRIRISS | KKNSYDNLSN | IIQFYQLWAH | ELFPKAKFKD | FMKICQTVGK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| TDPVLREYRV | SLFRDEMGMS | FDVGTRETGQ | DLERQSPMVE | EHVTSAEERP | IVADSFAQDK |
| 190 | 200 | 210 | 220 | 230 | 240 |
| RNVNNVDYDN | DEDDDIYHLS | YRNRRGRVLD | ERGNNETVLN | NVVPPKEDLD | ALLKTFRVQG |
| 250 | 260 | 270 | 280 | 290 | 300 |
| PVGLEENEKK | LLLGWLDAHR | KMEKGSMTEE | DVQLIQSLEE | WEMNDIEGQH | THYDLLPGGD |
| 310 | |||||
| EFGVDQDELD | AMKEMGF |