Q6DBR4

PR
Gene name
tipin (zgc:91928)
Protein name
TIMELESS-interacting protein
Names
Species
Danio rerio (Zebrafish) (Brachydanio rerio)
KEGG Pathway
dre:445058
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-85 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q6DBR4

Entry ID Method Resolution Chain Position Source
AF-Q6DBR4-F1 Predicted AlphaFoldDB

No variants for Q6DBR4

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q6DBR4

No associated diseases with Q6DBR4

5 regional properties for Q6DBR4

Type Name Position InterPro Accession
domain SANT/Myb domain 8 - 57 IPR001005-1
domain SANT/Myb domain 56 - 107 IPR001005-2
domain Myb domain 7 - 55 IPR017930-1
domain Myb domain 56 - 109 IPR017930-2
domain Pre-mRNA splicing factor component CDC5L/Cef1, second SANT/myb-like domain 57 - 108 IPR047240

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
chromatin The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
replication fork protection complex A protein complex conserved in eukaryotes and associated with the replication fork; the complex stabilizes stalled replication forks and is thought to be involved in coordinating leading- and lagging-strand synthesis and in replication checkpoint signaling.

1 GO annotations of molecular function

Name Definition
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

7 GO annotations of biological process

Name Definition
cell cycle phase transition The cell cycle process by which a cell commits to entering the next cell cycle phase.
cell division The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.
DNA replication checkpoint signaling A signal transduction process that contributes to a DNA replication checkpoint, that prevents the initiation of nuclear division until DNA replication is complete, thereby ensuring that progeny inherit a full complement of the genome.
mitotic intra-S DNA damage checkpoint signaling A mitotic cell cycle checkpoint that slows DNA synthesis in response to DNA damage by the prevention of new origin firing and the stabilization of slow replication fork progression.
positive regulation of cell population proliferation Any process that activates or increases the rate or extent of cell proliferation.
replication fork arrest Any process that stops, prevents, or reduces the frequency, rate or extent of DNA replication by impeding the progress of the DNA replication fork. Replication fork arrest is one of the 'quality control' processes ensuring that DNA-dependent DNA replication occurs correctly. DNA replication fork arrest during DNA-dependent DNA replication is not known to occur outside of cases where a replication error needs to be prevented or corrected.
replication fork protection Any process that prevents the collapse of stalled replication forks.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q04659 CSM3 Chromosome segregation in meiosis protein 3 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
Q5F416 TIPIN TIMELESS-interacting protein Gallus gallus (Chicken) PR
Q9BVW5 TIPIN TIMELESS-interacting protein Homo sapiens (Human) PR
10 20 30 40 50 60
MIDPLENGLF DIPDYEQIED ETFPPLPPPL SPGRAELEDD LFGNAEGEEE GEVSKLAEVP
70 80 90 100 110 120
VAKRRTVKRP RPKLDANRLI SEKGLPALRT LFEDVKFKGK GHETENLKLL MLKMENWAHR
130 140 150 160 170 180
LYPKMQFEEF IDKVENLGGK KEVQTCLKRI RLDMPITHED YVAEEAEIQV PEESVPSGDG
190 200 210 220 230 240
GFPEDPFIHS TPAPASLTEE QQQRIELNKR LALERRLAKQ KQLESTPISI QEDADEPSTS
250 260 270 280 290
SSGQFLSEEN PKTTSNQTPL KHKPAELQES PLHDNESSSH IANGIIDDDD DDDD