Q5F416
Gene name |
TIPIN (RCJMB04_3n6) |
Protein name |
TIMELESS-interacting protein |
Names |
|
Species |
Gallus gallus (Chicken) |
KEGG Pathway |
gga:415548 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q5F416
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q5F416-F1 | Predicted | AlphaFoldDB |
No variants for Q5F416
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q5F416 | |||||
No associated diseases with Q5F416
1 regional properties for Q5F416
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Chromosome segregation in meiosis protein 3 | 73 - 152 | IPR012923 |
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| chromatin | The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| replication fork protection complex | A protein complex conserved in eukaryotes and associated with the replication fork; the complex stabilizes stalled replication forks and is thought to be involved in coordinating leading- and lagging-strand synthesis and in replication checkpoint signaling. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| DNA binding | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). |
7 GO annotations of biological process
| Name | Definition |
|---|---|
| cell cycle phase transition | The cell cycle process by which a cell commits to entering the next cell cycle phase. |
| cell division | The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells. |
| DNA replication checkpoint signaling | A signal transduction process that contributes to a DNA replication checkpoint, that prevents the initiation of nuclear division until DNA replication is complete, thereby ensuring that progeny inherit a full complement of the genome. |
| mitotic intra-S DNA damage checkpoint signaling | A mitotic cell cycle checkpoint that slows DNA synthesis in response to DNA damage by the prevention of new origin firing and the stabilization of slow replication fork progression. |
| positive regulation of cell population proliferation | Any process that activates or increases the rate or extent of cell proliferation. |
| replication fork arrest | Any process that stops, prevents, or reduces the frequency, rate or extent of DNA replication by impeding the progress of the DNA replication fork. Replication fork arrest is one of the 'quality control' processes ensuring that DNA-dependent DNA replication occurs correctly. DNA replication fork arrest during DNA-dependent DNA replication is not known to occur outside of cases where a replication error needs to be prevented or corrected. |
| replication fork protection | Any process that prevents the collapse of stalled replication forks. |
3 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q04659 | CSM3 | Chromosome segregation in meiosis protein 3 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q9BVW5 | TIPIN | TIMELESS-interacting protein | Homo sapiens (Human) | PR |
| Q6DBR4 | tipin | TIMELESS-interacting protein | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAMIDPLENN | LFDLPDYENT | EDETFPPLPP | PTSPGRGDAE | WAQANGDPDG | NQQSETKDSS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| SAARKAVKRS | IPKLDANRLV | SERGLPALRH | MFDNVKFKGK | GHEAEDLKTL | LRHMEHWAHR |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LFPKLQFDDF | IDRVESLGNK | KEVQTCLKRI | RLDLPILHED | FTANEGGGGE | SNGLDMATEE |
| 190 | 200 | 210 | 220 | 230 | 240 |
| VHSFSGNVGE | LDSLPGTTLT | EEQQQRIKRN | RQLALERRQA | KMQCNSQSQH | DELSPSYPEE |
| 250 | 260 | 270 | 280 | ||
| ELNIPVARDL | TGALEDTQVT | ATNVAVTETE | DRERELQCAS | EKQ |