AiPD: Autoinhibited Protein Database

Q9BUN8

Gene name	DERL1
Protein name	Derlin-1
Names	Degradation in endoplasmic reticulum protein 1, DERtrin-1, Der1-like protein 1
Species	Homo sapiens (Human)
KEGG Pathway	hsa:79139
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

191-251 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

191-251 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

6 structures for Q9BUN8

Entry ID	Method	Resolution	Chain	Position	Source
5GLF	X-ray	225 A	B/D/F/H	239-250	PDB
7CZB	EM	380 A	A/B/C/D	1-251	PDB
7Y4W	EM	367 A	W/X/Y/Z	1-251	PDB
7Y53	EM	361 A	W/X/Y/Z	1-251	PDB
7Y59	EM	451 A	W/X/Y/Z	1-251	PDB
AF-Q9BUN8-F1	Predicted				AlphaFoldDB

173 variants for Q9BUN8

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA4862879 rs769701593	2	S>T		No	ClinGen ExAC gnomAD
rs759391999 CA4862878	3	D>N		No	ClinGen ExAC gnomAD
rs566765886 CA4862877	6	D>E		No	ClinGen 1000Genomes ExAC TOPMed
CA372120636 rs1281119062	7	W>L		No	ClinGen TOPMed gnomAD
rs369770184 CA4862876	7	W>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs746849899 CA4862875	10	S>G		No	ClinGen ExAC gnomAD
TCGA novel	10	S>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1335634052 CA372120486	11	I>M		No	ClinGen TOPMed
rs777366277 CA4862874	17	Y>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA4862872 rs747600019	21	A>P		No	ClinGen ExAC gnomAD
CA372120226 rs747600019	21	A>S		No	ClinGen ExAC gnomAD
rs1294476845 CA372120211	22	T>A		No	ClinGen gnomAD
rs754574395 CA4862870	23	V>A		No	ClinGen ExAC gnomAD
CA4862871 rs546528242	23	V>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA4862869 rs750871105	24	A>T		No	ClinGen ExAC gnomAD
CA372120114 rs1338597478	25	V>M		No	ClinGen TOPMed
rs1219166488 CA372120063	26	P>S		No	ClinGen TOPMed
CA4862868 rs373197192	27	L>*		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs751992286 CA184487108 CA184487104	27	L>F		No	ClinGen ExAC TOPMed gnomAD
CA4862867 rs373197192	27	L>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs764350174 CA4862865	28	V>I		No	ClinGen ExAC gnomAD
rs758694226 CA4862864	29	G>D		No	ClinGen ExAC gnomAD
CA372119968 rs1173968960	29	G>S		No	ClinGen TOPMed
rs1444367657 CA372119946	30	K>E		No	ClinGen TOPMed
rs765222212 CA4862862	34	I>L		No	ClinGen ExAC TOPMed gnomAD
rs765222212 CA372119872	34	I>V		No	ClinGen ExAC TOPMed gnomAD
rs1258327778 CA372119849	35	S>G		No	ClinGen gnomAD
rs369452020 CA372119825	36	P>A		No	ClinGen ESP ExAC TOPMed gnomAD
CA4862860 rs776404346	36	P>R		No	ClinGen ExAC TOPMed gnomAD
rs369452020 CA4862861	36	P>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA184487072 rs944425567	38	Y>C		No	ClinGen TOPMed
CA372119789 rs11551730	39	L>F		No	ClinGen gnomAD
CA372119785 rs1196874522	39	L>P		No	ClinGen gnomAD
CA4862858 rs760414753	41	L>F		No	ClinGen ExAC gnomAD
rs773004585 CA4862857	41	L>R		No	ClinGen ExAC gnomAD
CA372119745 rs1467736246	42	W>R		No	ClinGen TOPMed
rs1007797134 CA184487028	43	P>L		No	ClinGen TOPMed gnomAD
rs1293411526 CA372119723	43	P>S		No	ClinGen TOPMed gnomAD
rs1293411526 CA372119728	43	P>T		No	ClinGen TOPMed gnomAD
rs1586476186 CA372119704	44	E>A		No	ClinGen Ensembl
rs903522937 CA184486994	44	E>K		No	ClinGen TOPMed
CA372119691 rs1330879821	45	A>T		No	ClinGen gnomAD
CA372119678 rs1391889823	45	A>V		No	ClinGen gnomAD
rs376163583 CA4862854	46	F>C		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1009693355 CA184486987	50	F>V		No	ClinGen gnomAD
rs775066796 CA4862833	52	I>T		No	ClinGen ExAC gnomAD
CA4862831 rs747509219	53	W>C		No	ClinGen ExAC TOPMed
rs769491992 CA4862832	53	W>L		No	ClinGen ExAC TOPMed
CA4862830 rs778478169	57	T>A		No	ClinGen ExAC TOPMed gnomAD
rs778955625 CA4862827	58	A>P		No	ClinGen ExAC gnomAD
CA4862828 rs778955625	58	A>T		No	ClinGen ExAC gnomAD
CA4862826 rs755243736	59	T>A		No	ClinGen ExAC gnomAD
rs1285771566 CA372115301	63	P>S		No	ClinGen gnomAD
COSM1644543 CA4862825 rs753793629	65	G>C	salivary_gland [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs780179797 CA4862824	65	G>D		No	ClinGen ExAC gnomAD
CA4862820 rs761546720	77	Y>C		No	ClinGen ExAC gnomAD
rs751380124 CA4862819	78	F>L		No	ClinGen ExAC gnomAD
CA184478026 rs374946326	79	L>V		No	ClinGen ESP TOPMed
CA372114532 rs1486576035	80	Y>H		No	ClinGen TOPMed
CA372114434 rs1347146125	81	Q>R		No	ClinGen gnomAD
CA372114267 rs1190916416	84	T>M		No	ClinGen TOPMed
rs564730174 COSM461493 CA4862817	85	R>*	cervix Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs536205480 CA372114219	85	R>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs536205480 CA4862816	85	R>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs370493545 CA4862813	88	T>A		No	ClinGen ESP ExAC TOPMed gnomAD
CA4862800 rs751513605	90	A>G		No	ClinGen ExAC gnomAD
rs751513605 CA372111845	90	A>V		No	ClinGen ExAC gnomAD
CA372111796 rs1320323823	93	G>W		No	ClinGen TOPMed gnomAD
CA372111680 rs1236882453	98	Y>C		No	ClinGen TOPMed gnomAD
CA372111687 rs1485693919	98	Y>N		No	ClinGen gnomAD
rs768881035	99	L>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs765016394 CA4862795	101	M>I		No	ClinGen ExAC gnomAD
CA184474482 rs745793332	101	M>T		No	ClinGen TOPMed
rs374118585 CA4862796	101	M>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs759071104 CA4862794	102	L>F		No	ClinGen ExAC gnomAD
CA372111559 rs1295237031	103	L>R		No	ClinGen gnomAD
TCGA novel	108	C>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1355484846 CA372111388	110	V>A		No	ClinGen gnomAD
rs762376992 CA4862791	110	V>M		No	ClinGen ExAC TOPMed gnomAD
rs1336467423 CA372111166	112	T>S		No	ClinGen TOPMed
rs1216455462 CA372111155	113	G>S		No	ClinGen TOPMed
rs1480870541 CA372111101	116	M>V		No	ClinGen TOPMed
CA372111072 rs1018535591	117	D>G		No	ClinGen TOPMed gnomAD
CA184473557 rs1018535591	117	D>V		No	ClinGen TOPMed gnomAD
rs866862635 CA184473553	118	M>L		No	ClinGen Ensembl
CA372111043 rs1441864457	119	Q>K		No	ClinGen TOPMed
rs565379842 CA4862761	122	M>V		No	ClinGen 1000Genomes ExAC gnomAD
CA4862760 rs778848135	125	L>V		No	ClinGen ExAC gnomAD
CA372109529 rs1396676708	126	I>T		No	ClinGen gnomAD
CA4862755 rs766889550	131	Y>C		No	ClinGen ExAC TOPMed gnomAD
rs141463243 CA4862756	131	Y>H		No	ClinGen ESP ExAC TOPMed
CA184472753 rs969810276	136	L>V		No	ClinGen Ensembl
CA372109203 rs1488695272	138	R>G		No	ClinGen gnomAD
rs1397214421 CA372109089	140	M>I		No	ClinGen TOPMed
rs776029927 CA4862752	140	M>V		No	ClinGen ExAC gnomAD
rs765561360 CA4862751	141	I>S		No	ClinGen ExAC gnomAD
CA372108999 rs776797591	143	S>*		No	ClinGen ExAC TOPMed gnomAD
CA4862749 rs776797591	143	S>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs908963295 CA184472721	149	R>Q		No	ClinGen TOPMed gnomAD
rs984583610 CA184472714	151	K>R		No	ClinGen gnomAD
rs762024897 CA4862723	153	C>S		No	ClinGen ExAC gnomAD
rs146414335 CA4862722	154	Y>C		No	ClinGen ESP ExAC TOPMed gnomAD
rs146414335 CA184471949	154	Y>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA184471948 rs371727228	158	V>F		No	ClinGen ESP
TCGA novel	160	L>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA4862719 rs749024059	161	G>E		No	ClinGen ExAC gnomAD
rs779709272 CA4862718	163	N>S		No	ClinGen ExAC TOPMed gnomAD
rs769685055 CA4862717	164	Y>C		No	ClinGen ExAC TOPMed gnomAD
CA4862716 rs745483518	165	I>L		No	ClinGen ExAC gnomAD
rs1357852801 CA372107902	166	I>V		No	ClinGen gnomAD
CA4862714 rs756713761 COSM1095682	169	S>L	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA4862698 rs2272722 VAR_019516	171	I>V		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs200376396 CA4862697	172	N>S		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	176	G>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA372106952 rs1403733239	179	V>I		No	ClinGen gnomAD
rs200467011 CA184470435	182	L>I		No	ClinGen 1000Genomes
TCGA novel CA372106604 rs1586458468	187	M>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA Ensembl
CA4862695 rs770586414	187	M>T		No	ClinGen ExAC gnomAD
rs1586458466 CA372106554	189	R>K		No	ClinGen Ensembl
CA4862694 rs550182260	190	Y>C		No	ClinGen 1000Genomes ExAC gnomAD
rs372267337 CA4862693	192	M>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA4862692 rs571672566	194	L>M		No	ClinGen ExAC TOPMed gnomAD
rs780652342 CA4862690	195	G>*		No	ClinGen ExAC gnomAD
TCGA novel	198	N>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA372106229 rs1246979062	198	N>I		No	ClinGen gnomAD
CA372106196 rs1338624131	199	F>S		No	ClinGen TOPMed
CA4862689 rs200911646	200	L>I		No	ClinGen 1000Genomes ExAC gnomAD
rs767779165 CA4862687	200	L>P		No	ClinGen ExAC gnomAD
CA4862685 rs751887904	202	T>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs139154983 CA4862684	203	P>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs561331450 CA4862683	204	Q>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs765021552 CA4862661	208	R>C		No	ClinGen ExAC gnomAD
rs141975370 CA4862660	208	R>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA4862659 rs753835312	209	W>R		No	ClinGen ExAC gnomAD
rs1278112602 CA372104372	211	P>R		No	ClinGen TOPMed
rs1271445081 CA372104341	213	R>G		No	ClinGen TOPMed
CA372104312 rs1438101280	213	R>S		No	ClinGen gnomAD
CA4862656 rs377395425	215	G>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA184468226 rs938385519	217	V>I		No	ClinGen TOPMed gnomAD
CA372104052 rs1198249688	222	V>L		No	ClinGen TOPMed gnomAD
CA372104055 rs1198249688	222	V>M		No	ClinGen TOPMed gnomAD
rs771781123 CA4862654	223	P>L		No	ClinGen ExAC TOPMed gnomAD
rs1314875568	224	P>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs973758787 CA184468213	224	P>R		No	ClinGen TOPMed gnomAD
CA4862653 rs761159619	225	A>P		No	ClinGen ExAC
CA4862652 rs773906113	226	S>G		No	ClinGen ExAC gnomAD
COSM3382053 CA4862650 rs746354501	227	M>T	pancreas [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA4862651 rs768107833	227	M>V		No	ClinGen ExAC gnomAD
COSM1203404 rs1449530519 CA372103880	229	R>*	large_intestine [Cosmic]	No	ClinGen cosmic curated gnomAD
CA4862649 rs781773566	229	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1331613927 CA372103820	231	A>P		No	ClinGen gnomAD
CA4862648 rs771378929	233	Q>E		No	ClinGen ExAC gnomAD
rs1352283961 CA372103748	233	Q>R		No	ClinGen gnomAD
rs747396883 CA4862647	234	N>H		No	ClinGen ExAC gnomAD
CA184468190 rs948575070	234	N>S		No	ClinGen Ensembl
rs71514794 CA184468188	236	G>E		No	ClinGen Ensembl
CA4862645 rs145513704	236	G>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs779040155 CA4862643	238	G>R		No	ClinGen ExAC TOPMed gnomAD
CA372103549 rs1586455872	239	R>G		No	ClinGen Ensembl
rs149704655 CA372103503	240	H>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA4862642 rs149704655	240	H>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA372103517 rs1173357357	240	H>Y		No	ClinGen TOPMed
rs1456575352 CA372103471	241	N>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA372103417 rs1586455839	242	W>C		No	ClinGen Ensembl
CA4862640 rs553707578	243	G>V		No	ClinGen 1000Genomes ExAC gnomAD
CA4862638 rs750233509	247	R>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1378125719 CA372103271	247	R>Q		No	ClinGen TOPMed gnomAD
rs1372615690 CA372103261	248	L>F		No	ClinGen gnomAD
CA4862637 rs767281160	248	L>P		No	ClinGen ExAC TOPMed gnomAD
CA372103252 rs767281160	248	L>R		No	ClinGen ExAC TOPMed gnomAD
CA372103193 rs1370773994	250	D>A		No	ClinGen gnomAD
CA372103190 rs1370773994	250	D>G		No	ClinGen gnomAD
rs761512599 CA4862636	251	Q>R		No	ClinGen ExAC TOPMed gnomAD

No associated diseases with Q9BUN8

No regional properties for Q9BUN8

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for Q9BUN8

Functions

		Description
EC Number
Subcellular Localization	Endoplasmic reticulum membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

11 GO annotations of cellular component

Name	Definition
Derlin-1 retrotranslocation complex	A protein complex that functions in the retrotranslocation step of ERAD (ER-associated protein degradation), and includes at its core Derlin-1 oligomers forming a retrotranslocation channel.
Derlin-1-VIMP complex	A protein complex containing, in mammals, Derlin-1 and VCP-interacting membrane protein (VIMP). The complex links the p97/VCP-containing ATPase complex with Derlin-1 during translocation of protein substrates from the endoplasmic reticulum to the cytosol for degradation by the cytosolic proteasome.
early endosome	A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways.
endoplasmic reticulum	The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
endoplasmic reticulum membrane	The lipid bilayer surrounding the endoplasmic reticulum.
endoplasmic reticulum quality control compartment	A subcompartment of the endoplasmic reticulum in which proteins with improper or incorrect folding accumulate. Enzymes in this compartment direct proteins with major folding problems to translocation to the cytosol and degradation, and proteins with minor folding problems to the ER, to interact with chaperon proteins.
Hrd1p ubiquitin ligase ERAD-L complex	A multiprotein complex that recognizes and ubiquitinates proteins with misfolded luminal domains during ER-associated protein degradation (ERAD). In S. cerevisiae, this complex contains the ubiquitin ligase Hrd1p.
integral component of endoplasmic reticulum membrane	The component of the endoplasmic reticulum membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
integral component of membrane	The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
late endosome	A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center.
membrane	A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.

10 GO annotations of molecular function

Name	Definition
ATPase binding	Binding to an ATPase, any enzyme that catalyzes the hydrolysis of ATP.
identical protein binding	Binding to an identical protein or proteins.
MHC class I protein binding	Binding to a major histocompatibility complex class I molecule; a set of molecules displayed on cell surfaces that are responsible for lymphocyte recognition and antigen presentation.
misfolded protein binding	Binding to a misfolded protein.
protease binding	Binding to a protease or a peptidase.
protein-containing complex binding	Binding to a macromolecular complex.
signal recognition particle binding	Binding to a signal recognition particle.
signaling receptor activity	Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response.
ubiquitin protein ligase binding	Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins.
ubiquitin-specific protease binding	Binding to a ubiquitin-specific protease.

10 GO annotations of biological process

Name	Definition
endoplasmic reticulum unfolded protein response	The series of molecular signals generated as a consequence of the presence of unfolded proteins in the endoplasmic reticulum (ER) or other ER-related stress; results in changes in the regulation of transcription and translation.
ER-associated misfolded protein catabolic process	The chemical reactions and pathways resulting in the breakdown of misfolded proteins transported from the endoplasmic reticulum and targeted to cytoplasmic proteasomes for degradation.
ERAD pathway	The protein catabolic pathway which targets endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. It begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein modifications necessary for correct substrate transfer (e.g. ubiquitination), transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome.
establishment of protein localization	The directed movement of a protein to a specific location.
positive regulation of protein binding	Any process that activates or increases the frequency, rate or extent of protein binding.
positive regulation of protein ubiquitination	Any process that activates or increases the frequency, rate or extent of the addition of ubiquitin groups to a protein.
protein destabilization	Any process that decreases the stability of a protein, making it more vulnerable to degradative processes or aggregation.
response to unfolded protein	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an unfolded protein stimulus.
retrograde protein transport, ER to cytosol	The directed movement of unfolded or misfolded proteins from the endoplasmic reticulum to the cytosol through the translocon.
ubiquitin-dependent ERAD pathway	The series of steps necessary to target endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. Begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein ubiquitination necessary for correct substrate transfer, transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome.

4 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q4G2J6	DER1.1	Derlin-1.1	Zea mays (Maize)	PR
Q4G2J5	DER1.2	Derlin-1.2	Zea mays (Maize)	PR
Q93561	cup-2	Derlin-1	Caenorhabditis elegans	PR
Q8VZU9	DER1	Derlin-1	Arabidopsis thaliana (Mouse-ear cress)	PR

10	20	30	40	50	60
MSDIGDWFRS	IPAITRYWFA	ATVAVPLVGK	LGLISPAYLF	LWPEAFLYRF	QIWRPITATF
70	80	90	100	110	120
YFPVGPGTGF	LYLVNLYFLY	QYSTRLETGA	FDGRPADYLF	MLLFNWICIV	ITGLAMDMQL
130	140	150	160	170	180
LMIPLIMSVL	YVWAQLNRDM	IVSFWFGTRF	KACYLPWVIL	GFNYIIGGSV	INELIGNLVG
190	200	210	220	230	240
HLYFFLMFRY	PMDLGGRNFL	STPQFLYRWL	PSRRGGVSGF	GVPPASMRRA	ADQNGGGGRH
250
NWGQGFRLGD	Q