Q4G2J5

PR
Gene name
DER1.2 (SOR)
Protein name
Derlin-1.2
Names
ZmDerlin1-2
Species
Zea mays (Maize)
KEGG Pathway
zma:606470
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

188-243 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q4G2J5

Entry ID Method Resolution Chain Position Source
AF-Q4G2J5-F1 Predicted AlphaFoldDB

16 variants for Q4G2J5

Variant ID(s) Position Change Description Diseaes Association Provenance
PZE06130164198 30 R>Q No EnsemblPlants
PZE06130164212 35 N>D No EnsemblPlants
PZE06130164233 42 Y>H No EnsemblPlants
PZE06130164624 55 I>L No EnsemblPlants
PZE06130164662 67 I>M No EnsemblPlants
PZE06130164666 69 F>L No EnsemblPlants
PZE06130164821 87 A>T No EnsemblPlants
PZE06130165117 150 K>R No EnsemblPlants
PZE06130165279 161 L>I No EnsemblPlants
PZE06130165289 164 I>T No EnsemblPlants
PZE06130165288 164 I>V No EnsemblPlants
PZE06130165329 177 M>I No EnsemblPlants
PZE06130165393 199 K>E No EnsemblPlants
PZE06130165547 205 H>Y No EnsemblPlants
PZE06130165601 223 A>P No EnsemblPlants
PZE06130165610 226 N>Y No EnsemblPlants

No associated diseases with Q4G2J5

No regional properties for Q4G2J5

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q4G2J5

Functions

Description
EC Number
Subcellular Localization
  • Endoplasmic reticulum membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
Hrd1p ubiquitin ligase ERAD-L complex A multiprotein complex that recognizes and ubiquitinates proteins with misfolded luminal domains during ER-associated protein degradation (ERAD). In S. cerevisiae, this complex contains the ubiquitin ligase Hrd1p.
integral component of endoplasmic reticulum membrane The component of the endoplasmic reticulum membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

1 GO annotations of molecular function

Name Definition
misfolded protein binding Binding to a misfolded protein.

2 GO annotations of biological process

Name Definition
endoplasmic reticulum unfolded protein response The series of molecular signals generated as a consequence of the presence of unfolded proteins in the endoplasmic reticulum (ER) or other ER-related stress; results in changes in the regulation of transcription and translation.
ubiquitin-dependent ERAD pathway The series of steps necessary to target endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. Begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein ubiquitination necessary for correct substrate transfer, transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome.

4 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9BUN8 DERL1 Derlin-1 Homo sapiens (Human) PR
Q4G2J6 DER1.1 Derlin-1.1 Zea mays (Maize) PR
Q93561 cup-2 Derlin-1 Caenorhabditis elegans PR
Q8VZU9 DER1 Derlin-1 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MSSPAEYYKS LPPISKAYGT LCFFTTVLVR LHILNPLFLY LYYPRVFKKF EVWRIFTSFF
70 80 90 100 110 120
FLGPFSINFG IRLLMIARYG VMLEKGAFDK RTADFLWMMI FGAISLLVLS VIPQLNTYVL
130 140 150 160 170 180
GLPMVSMLVY VWSRENPNAQ INIYGILQLK AFYLPWVMLL LDVIFGSPLM PGLLGIMVGH
190 200 210 220 230 240
LYYYFAVLHP LATGKNYLKT PKWVHKIVAR FRIGMQANAP VRAPANGNAG TGAFRGRSYR
LNQ