Q8VZU9
Gene name |
DER1 (At4g29330, F17A13.150) |
Protein name |
Derlin-1 |
Names |
AtDerlin1-1 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT4G29330 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8VZU9
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8VZU9-F1 | Predicted | AlphaFoldDB |
13 variants for Q8VZU9
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH14310782 | 16 | K>R | No | 1000Genomes | |
| ENSVATH02939713 | 37 | V>G | No | 1000Genomes | |
| tmp_4_14445821_T_C | 61 | F>S | No | 1000Genomes | |
| tmp_4_14446003_G_A | 93 | A>T | No | 1000Genomes | |
| ENSVATH00544083 | 160 | A>T | No | 1000Genomes | |
| ENSVATH00544084 | 178 | A>V | No | 1000Genomes | |
| tmp_4_14446641_A_G | 195 | K>R | No | 1000Genomes | |
| ENSVATH02939718 | 224 | G>D | No | 1000Genomes | |
| tmp_4_14446861_T_A | 237 | V>E | No | 1000Genomes | |
| tmp_4_14446881_T_A | 244 | S>T | No | 1000Genomes | |
| ENSVATH02939719 | 250 | P>H | No | 1000Genomes | |
| tmp_4_14446930_G_A | 260 | R>Q | No | 1000Genomes | |
| tmp_4_14446939_G_A | 263 | R>H | No | 1000Genomes |
No associated diseases with Q8VZU9
No regional properties for Q8VZU9
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q8VZU9 | |||
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| Hrd1p ubiquitin ligase ERAD-L complex | A multiprotein complex that recognizes and ubiquitinates proteins with misfolded luminal domains during ER-associated protein degradation (ERAD). In S. cerevisiae, this complex contains the ubiquitin ligase Hrd1p. |
| integral component of endoplasmic reticulum membrane | The component of the endoplasmic reticulum membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| misfolded protein binding | Binding to a misfolded protein. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| endoplasmic reticulum unfolded protein response | The series of molecular signals generated as a consequence of the presence of unfolded proteins in the endoplasmic reticulum (ER) or other ER-related stress; results in changes in the regulation of transcription and translation. |
| ubiquitin-dependent ERAD pathway | The series of steps necessary to target endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. Begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein ubiquitination necessary for correct substrate transfer, transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome. |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSSPGEFYNS | LPPITKAYGT | LCFFTTVATQ | LGLVAPVHIA | LIPELVLKQF | QIWRLITNLF |
| 70 | 80 | 90 | 100 | 110 | 120 |
| FLGGFSINFG | IRLLMIARYG | VQLEKGPFER | RTADFLWMMI | FGSFTLLVLS | VIPFFWTPFL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| GVSLVFMLLY | LWSREFPNAN | ISLYGLVTLK | AFYLPWAMLA | LDVIFGSPIM | PDLLGIIAGH |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LYYFLTVLHP | LATGKNYLKT | PKWVNKIVAR | WRIGAPVASV | RQAGGVGAAG | PGAGGGVGGG |
| 250 | 260 | ||||
| GAYSSARAPP | ESSNTAFRGR | SYRLTD |