Q99MK9
PR
Gene name |
Rassf1 |
Protein name |
Ras association domain-containing protein 1 |
Names |
Protein 123F2 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:56289 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q99MK9
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q99MK9-F1 | Predicted | AlphaFoldDB |
10 variants for Q99MK9
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389079231 | 111 | S>Y | No | EVA | |
| rs3389072549 | 121 | E>G | No | EVA | |
| rs3400693993 | 126 | E>V | No | EVA | |
| rs13473813 | 151 | F>L | No | EVA | |
| rs3389016584 | 181 | K>* | No | EVA | |
| rs3389075568 | 216 | V>I | No | EVA | |
| rs3389073747 | 219 | R>* | No | EVA | |
| rs3389079242 | 220 | T>S | No | EVA | |
| rs583059702 | 250 | R>Q | No | EVA | |
| rs3389045858 | 268 | L>Q | No | EVA |
No associated diseases with Q99MK9
4 regional properties for Q99MK9
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Ras-associating domain | 194 - 288 | IPR000159 |
| domain | Protein kinase C-like, phorbol ester/diacylglycerol-binding domain | 44 - 102 | IPR002219 |
| domain | SARAH domain | 290 - 337 | IPR011524 |
| domain | Ras association domain-containing protein 1, RA domain | 130 - 286 | IPR033600 |
Functions
6 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| microtubule | Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. |
| microtubule cytoskeleton | The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins. |
| microtubule organizing center | An intracellular structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| spindle pole | Either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| identical protein binding | Binding to an identical protein or proteins. |
| metal ion binding | Binding to a metal ion. |
| protein N-terminus binding | Binding to a protein N-terminus, the end of any peptide chain at which the 2-amino (or 2-imino) function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue. |
| small GTPase binding | Binding to a small monomeric GTPase. |
9 GO annotations of biological process
| Name | Definition |
|---|---|
| cell cycle | The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division. |
| cellular response to DNA damage stimulus | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism. |
| positive regulation of protein ubiquitination | Any process that activates or increases the frequency, rate or extent of the addition of ubiquitin groups to a protein. |
| protein stabilization | Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation. |
| Ras protein signal transduction | The series of molecular signals within the cell that are mediated by a member of the Ras superfamily of proteins switching to a GTP-bound active state. |
| regulation of cell cycle | Any process that modulates the rate or extent of progression through the cell cycle. |
| regulation of cell cycle G1/S phase transition | Any signalling pathway that modulates the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the cell cycle. |
| regulation of microtubule cytoskeleton organization | Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins. |
| signal transduction | The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. |
7 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q6ZTQ3 | RASSF6 | Ras association domain-containing protein 6 | Homo sapiens (Human) | PR |
| Q8WWW0 | RASSF5 | Ras association domain-containing protein 5 | Homo sapiens (Human) | PR |
| Q9NS23 | RASSF1 | Ras association domain-containing protein 1 | Homo sapiens (Human) | PR |
| Q80UQ2 | Rassf6 | Ras association domain-containing protein 6 | Mus musculus (Mouse) | PR |
| Q5EBH1 | Rassf5 | Ras association domain-containing protein 5 | Mus musculus (Mouse) | PR |
| O35141 | Rassf5 | Ras association domain-containing protein 5 | Rattus norvegicus (Rat) | PR |
| Q4QR82 | Rassf6 | Ras association domain-containing protein 6 | Rattus norvegicus (Rat) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSAEPELIEL | RELAPSGRIG | PGRTRLERAN | ALRIAPGTTR | NPSQQHVPGR | GHRFQPAGPT |
| 70 | 80 | 90 | 100 | 110 | 120 |
| THTWCDLCGD | FIWGVVRKGL | QCAHCKFTCH | YRCRALVCLD | CCGPRDLGWD | SALERDTNVD |
| 130 | 140 | 150 | 160 | 170 | 180 |
| EAVERETPDL | SQAETEQKIK | DYNGQINSNL | FMSLNKDGSY | TGFIKVQLKL | VRPVSVPSSK |
| 190 | 200 | 210 | 220 | 230 | 240 |
| KPPSLQDARR | GTGRSTAVKR | RTSFYLPKDA | IKHLHVLSRT | RAREVIEALL | RKFMVVDDPR |
| 250 | 260 | 270 | 280 | 290 | 300 |
| KFALFERTER | HGQVYLRKLS | DDEQPLKLRL | LAGPSEKALS | FVLKENDSGE | VNWDAFSMPE |
| 310 | 320 | 330 | |||
| LHNFLRILQR | EEEEHLRQIL | QKYSRCRQKI | QEALHACPLG |