Q5EBH1
PR
Gene name |
Rassf5 (Nore1, Rapl) |
Protein name |
Ras association domain-containing protein 5 |
Names |
New ras effector 1, Regulator for cell adhesion and polarization enriched in lymphoid tissues, RAPL |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:54354 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
5 structures for Q5EBH1
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 1RFH | NMR | - | A | 108-166 | PDB |
| 2FNF | NMR | - | X | 95-166 | PDB |
| 2YMY | X-ray | 169 A | A/B | 370-413 | PDB |
| 3DDC | X-ray | 180 A | B | 200-357 | PDB |
| AF-Q5EBH1-F1 | Predicted | AlphaFoldDB |
18 variants for Q5EBH1
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388494541 | 123 | L>Q | No | EVA | |
| rs3388497918 | 173 | L>P | No | EVA | |
| rs237284655 | 175 | R>T | No | EVA | |
| rs3388498834 | 183 | T>I | No | EVA | |
| rs3388497412 | 211 | D>V | No | EVA | |
| rs3390645979 | 223 | M>T | No | EVA | |
| rs3388498188 | 259 | A>V | No | EVA | |
| rs3388497959 | 265 | P>L | No | EVA | |
| rs3388498807 | 280 | D>E | No | EVA | |
| rs3388497776 | 303 | K>M | No | EVA | |
| rs3388494579 | 347 | T>I | No | EVA | |
| rs3388498278 | 365 | D>G | No | EVA | |
| rs3388496547 | 383 | E>Q | No | EVA | |
| rs3388497759 | 384 | Q>H | No | EVA | |
| rs3388495650 | 388 | H>R | No | EVA | |
| rs3388498836 | 389 | Q>* | No | EVA | |
| rs3388498618 | 390 | L>M | No | EVA | |
| rs3388497713 | 393 | K>M | No | EVA |
No associated diseases with Q5EBH1
No regional properties for Q5EBH1
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q5EBH1 | |||
Functions
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| microtubule | Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| identical protein binding | Binding to an identical protein or proteins. |
| metal ion binding | Binding to a metal ion. |
| small GTPase binding | Binding to a small monomeric GTPase. |
7 GO annotations of biological process
| Name | Definition |
|---|---|
| apoptotic process | A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died. |
| lymphocyte proliferation | The expansion of a lymphocyte population by cell division. |
| negative regulation of lymphocyte proliferation | Any process that stops, prevents or reduces the rate or extent of lymphocyte proliferation. |
| positive regulation of protein ubiquitination | Any process that activates or increases the frequency, rate or extent of the addition of ubiquitin groups to a protein. |
| regulation of apoptotic process | Any process that modulates the occurrence or rate of cell death by apoptotic process. |
| regulation of protein localization to nucleus | Any process that modulates the frequency, rate or extent of protein localization to nucleus. |
| signal transduction | The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. |
7 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q6ZTQ3 | RASSF6 | Ras association domain-containing protein 6 | Homo sapiens (Human) | PR |
| Q9NS23 | RASSF1 | Ras association domain-containing protein 1 | Homo sapiens (Human) | PR |
| Q8WWW0 | RASSF5 | Ras association domain-containing protein 5 | Homo sapiens (Human) | PR |
| Q80UQ2 | Rassf6 | Ras association domain-containing protein 6 | Mus musculus (Mouse) | PR |
| Q99MK9 | Rassf1 | Ras association domain-containing protein 1 | Mus musculus (Mouse) | PR |
| Q4QR82 | Rassf6 | Ras association domain-containing protein 6 | Rattus norvegicus (Rat) | PR |
| O35141 | Rassf5 | Ras association domain-containing protein 5 | Rattus norvegicus (Rat) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MASPAIGQRP | YPLLLDPEPP | RYLQSLGGTE | PPPPARPRRC | IPTALIPAAG | ASEDRGGRRS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| GRRDPEPTPR | DCRHARPVRP | GLQPRLRLRP | GSHRPRDVRS | IFEQPQDPRV | LAERGEGHRF |
| 130 | 140 | 150 | 160 | 170 | 180 |
| VELALRGGPG | WCDLCGREVL | RQALRCANCK | FTCHSECRSL | IQLDCRQKGG | PALDRRSPES |
| 190 | 200 | 210 | 220 | 230 | 240 |
| TLTPTLNQNV | CKAVEETQHP | PTIQEIKQKI | DSYNSREKHC | LGMKLSEDGT | YTGFIKVHLK |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LRRPVTVPAG | IRPQSIYDAI | KEVNPAATTD | KRTSFYLPLD | AIKQLHISST | TTVSEVIQGL |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LKKFMVVDNP | QKFALFKRIH | KDGQVLFQKL | SIADYPLYLR | LLAGPDTDVL | SFVLKENETG |
| 370 | 380 | 390 | 400 | 410 | |
| EVEWDAFSIP | ELQNFLTILE | KEEQDKIHQL | QKKYNKFRQK | LEEALRESQG | KPG |