AiPD: Autoinhibited Protein Database

Q8WWW0

Gene name	RASSF5 (NORE1, RAPL)
Protein name	Ras association domain-containing protein 5
Names	Fc alpha/mu receptor, New ras effector 1, Regulator for cell adhesion and polarization enriched in lymphoid tissues, RAPL
Species	Homo sapiens (Human)
KEGG Pathway	hsa:83593
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-144 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

1-144 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

3 structures for Q8WWW0

Entry ID	Method	Resolution	Chain	Position	Source
4LGD	X-ray	305 A	E/F/G/H	365-413	PDB
4OH8	X-ray	228 A	B	366-418	PDB
AF-Q8WWW0-F1	Predicted				AlphaFoldDB

347 variants for Q8WWW0

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA344461332 rs1553393899	3	M>I		No	ClinGen gnomAD
CA344461322 CA344461323 rs1553393895	3	M>L		No	ClinGen gnomAD
CA344461324 rs1553393895	3	M>V		No	ClinGen gnomAD
CA344461366 rs1553393905	7	A>D		No	ClinGen gnomAD
rs1553393905 CA344461370	7	A>V		No	ClinGen gnomAD
rs1572281637 CA344461373	8	I>V		No	ClinGen Ensembl
rs1015628700 CA36534791	9	G>A		No	ClinGen TOPMed
rs868979518 CA344461378	9	G>W		No	ClinGen Ensembl
rs1364626634 CA344461390	10	Q>H		No	ClinGen TOPMed gnomAD
rs868946180 CA344461393	11	R>C		No	ClinGen TOPMed gnomAD
rs868946180 CA344461391	11	R>S		No	ClinGen TOPMed gnomAD
rs1431058319 CA344461400	12	P>L		No	ClinGen TOPMed gnomAD
rs1553393920 CA344461399	12	P>S		No	ClinGen gnomAD
rs782180379 CA1361986	13	Y>D		No	ClinGen ExAC gnomAD
CA1361987 rs782359788	13	Y>S		No	ClinGen ExAC gnomAD
CA1361988 rs781952718	14	P>L		No	ClinGen ExAC gnomAD
CA344461412 rs781952718	14	P>Q		No	ClinGen ExAC gnomAD
CA344461411 rs1416774848	14	P>S		No	ClinGen TOPMed gnomAD
rs1416774848 CA344461409	14	P>T		No	ClinGen TOPMed gnomAD
rs782422450 CA1361990	15	L>I		No	ClinGen ExAC gnomAD
rs1553393931 CA344461418	16	L>I		No	ClinGen gnomAD
rs782066092 CA1361992	16	L>Q		No	ClinGen ExAC gnomAD
rs868966664 CA344461428	17	L>F		No	ClinGen Ensembl
CA344461432 rs1553393935	18	D>A	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1553393936 CA344461438	19	P>S		No	ClinGen gnomAD
rs782073723 CA344461444	20	E>*		No	ClinGen ExAC gnomAD
CA1361995 rs782073723	20	E>K		No	ClinGen ExAC gnomAD
CA344461443 rs782073723	20	E>Q		No	ClinGen ExAC gnomAD
rs1553393942 CA344461453	21	P>Q		No	ClinGen gnomAD
CA344461452 rs1553393941	21	P>T		No	ClinGen gnomAD
rs782799787 CA1361996	22	P>S		No	ClinGen ExAC TOPMed gnomAD
CA1361997 rs781866355	23	R>L		No	ClinGen ExAC gnomAD
CA344461461 rs1553393948	23	R>S		No	ClinGen gnomAD
CA344461483 rs1553393959	26	Q>R		No	ClinGen TOPMed
rs1553393961 CA344461490	27	S>N		No	ClinGen gnomAD
rs1553393961 CA344461491	27	S>T		No	ClinGen gnomAD
rs781808271 CA344461497	28	L>P		No	ClinGen ExAC TOPMed gnomAD
rs781808271 CA1362000	28	L>Q		No	ClinGen ExAC TOPMed gnomAD
CA344461500 rs1553393964	29	S>G		No	ClinGen gnomAD
CA344461507 rs967794608	30	G>C		No	ClinGen gnomAD
rs967794608 CA36534878	30	G>S		No	ClinGen gnomAD
rs782610236 CA1362002	31	P>S		No	ClinGen ExAC TOPMed gnomAD
CA36534889 rs977724049	32	E>D		No	ClinGen TOPMed
CA344461518 rs1553393969	32	E>Q		No	ClinGen gnomAD
CA344461534 rs1402818896	34	P>L		No	ClinGen TOPMed
rs369172848 CA36534890	36	P>T		No	ClinGen gnomAD
CA36534893 rs923642211	37	P>S		No	ClinGen Ensembl
rs923642211 CA36534891	37	P>T		No	ClinGen Ensembl
CA344461552 rs1553393978	38	P>A		No	ClinGen gnomAD
CA1362005 rs557108539	38	P>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA344461554 rs557108539	38	P>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA1362004 rs557108539	38	P>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1169220169 CA344461561	39	D>E		No	ClinGen TOPMed gnomAD
rs1344667401	39	D>T	Variant assessed as Somatic; 0.0001471 impact. [NCI-TCGA]	No	NCI-TCGA
rs993098629 CA36534943	40	R>L		No	ClinGen Ensembl
rs934881220 CA36534935	40	R>W		No	ClinGen TOPMed gnomAD
CA36534945 rs917381880	42	S>L		No	ClinGen Ensembl
CA344461580 rs1174941122	43	R>H		No	ClinGen TOPMed gnomAD
rs782327060 CA1362008	44	L>F		No	ClinGen ExAC TOPMed gnomAD
rs1252996743 CA344461586	44	L>P		No	ClinGen TOPMed
CA36534949 rs577132400	45	C>F		No	ClinGen 1000Genomes TOPMed gnomAD
rs1553393994 CA344461589	45	C>R		No	ClinGen gnomAD
rs1553393995 CA344461599	46	V>L		No	ClinGen gnomAD
rs888516223 CA36534952	47	P>L		No	ClinGen TOPMed gnomAD
rs941467957 CA344461617	48	A>E		No	ClinGen TOPMed gnomAD
CA1362009 rs782563542	48	A>T		No	ClinGen ExAC gnomAD
CA36534960 rs941467957	48	A>V		No	ClinGen TOPMed gnomAD
rs1553393999 CA344461631	50	L>H		No	ClinGen gnomAD
CA344461641 rs1221612339	51	S>F		No	ClinGen TOPMed
rs181163167 CA1362010	53	A>E		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs181163167 CA344461658	53	A>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs782334742 CA1362011	54	P>S		No	ClinGen ExAC TOPMed
CA36534971 CA1362012 rs559841670	55	G>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs782119488 CA1362013	56	A>G		No	ClinGen ExAC TOPMed gnomAD
rs1553394008 CA344461683	57	R>C		No	ClinGen gnomAD
CA344461685 rs1553394009	57	R>H		No	ClinGen gnomAD
CA1362014 rs574913315	58	E>K		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs782024454 CA1362015	60	R>G		No	ClinGen ExAC TOPMed gnomAD
rs782024454 CA344461707	60	R>S		No	ClinGen ExAC TOPMed gnomAD
CA344461715 rs1161874928	61	S>G		No	ClinGen TOPMed
CA344461725 rs1006706460	62	A>S		No	ClinGen TOPMed gnomAD
CA36534996 rs1006706460	62	A>T		No	ClinGen TOPMed gnomAD
CA36535017 rs967762093	63	R>Q		No	ClinGen TOPMed
CA36535011 rs1022123030	63	R>W		No	ClinGen TOPMed gnomAD
CA344461743 rs1201672798	64	R>K		No	ClinGen TOPMed gnomAD
rs1553394014 CA344461793	67	R>Q		No	ClinGen gnomAD
rs561918883 CA1362017	68	G>W		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA1362018 rs781843602	69	N>I		No	ClinGen ExAC gnomAD
CA344461825 rs1217742773	71	E>K		No	ClinGen TOPMed
rs142795603 CA1362019	72	P>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1305805960 CA344461851	73	P>L		No	ClinGen TOPMed gnomAD
rs1553394029 CA344461845	73	P>T		No	ClinGen gnomAD
rs1553394032 CA344461866	75	R>G		No	ClinGen gnomAD
rs1228541045 CA344461870	75	R>Q		No	ClinGen TOPMed gnomAD
rs960422165 CA344461897	78	R>*		No	ClinGen TOPMed gnomAD
rs960422165 CA36535056	78	R>G		No	ClinGen TOPMed gnomAD
CA1362020 rs782795686	79	P>S		No	ClinGen ExAC TOPMed gnomAD
rs781898198 CA1362021	80	A>T		No	ClinGen ExAC TOPMed gnomAD
rs782542315 CA344461926	81	R>C		No	ClinGen ExAC TOPMed gnomAD
rs782542315 CA1362022	81	R>G		No	ClinGen ExAC TOPMed gnomAD
CA1362023 rs550837779	81	R>L		No	ClinGen 1000Genomes ExAC gnomAD
CA36535087 rs570368124	82	P>R		No	ClinGen 1000Genomes TOPMed gnomAD
CA344461965 rs1425836417	84	R>L		No	ClinGen TOPMed
CA344461961 rs1553394040	84	R>W		No	ClinGen gnomAD
rs1383454282 CA344461984	86	G>S		No	ClinGen TOPMed
rs57865548 CA344461997	87	L>V		No	ClinGen gnomAD
rs781788863 CA1362024	88	Q>L		No	ClinGen ExAC TOPMed gnomAD
rs532720302 CA1362025	89	Q>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs933991594 CA36535137	92	R>P		No	ClinGen TOPMed gnomAD
CA344462084 rs1259940272	95	P>S		No	ClinGen TOPMed
rs1553394056 CA344462105	97	A>T		No	ClinGen gnomAD
CA344462115 rs1361242732	98	P>S		No	ClinGen TOPMed
rs782375171 CA1362028	99	R>Q		No	ClinGen ExAC
rs889707187 CA36535169	100	P>A		No	ClinGen gnomAD
rs1007251864 CA36535174	100	P>L		No	ClinGen Ensembl
CA344462127 rs889707187	100	P>S		No	ClinGen gnomAD
rs782694757 CA344462148	101	R>C		No	ClinGen ExAC TOPMed gnomAD
rs782694757 CA1362030	101	R>G		No	ClinGen ExAC TOPMed gnomAD
rs782694757 CA344462135	101	R>S		No	ClinGen ExAC TOPMed gnomAD
rs1553394068 CA344462170	103	V>G		No	ClinGen gnomAD
rs782281850 CA1362031	103	V>M		No	ClinGen ExAC gnomAD
CA344462172 rs1553394070	104	R>G		No	ClinGen gnomAD
rs1361678222 CA344462176	104	R>L		No	ClinGen TOPMed
CA344462171 rs1553394070	104	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA344462182 rs1294550945	105	S>N		No	ClinGen TOPMed
CA344462191 rs1553394074	106	I>V		No	ClinGen gnomAD
CA344462206 rs1553394075	107	F>C		No	ClinGen gnomAD
CA344462223 rs1459609445	108	E>*		No	ClinGen TOPMed gnomAD
CA344462234 rs1553394078	108	E>D		No	ClinGen gnomAD
CA344462239 rs1553394080	109	Q>*		No	ClinGen gnomAD
rs903699582 CA36535189	111	Q>P		No	ClinGen TOPMed
rs1163205275 CA344462276	112	D>E		No	ClinGen TOPMed gnomAD
TCGA novel	112	D>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA36535190 rs546298221	113	P>L		No	ClinGen 1000Genomes
rs1430445939 CA344462282	113	P>S		No	ClinGen TOPMed
rs1392110046 CA344462288	114	R>G		No	ClinGen TOPMed gnomAD
CA1362032 rs782332774	115	V>G		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	117	A>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1553394093 CA344462312	117	A>V		No	ClinGen gnomAD
CA344462322 rs1553394094	119	R>*		No	ClinGen gnomAD
CA1362033 rs781924171	120	G>D		No	ClinGen ExAC gnomAD
TCGA novel	122	G>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA36535213 rs1030721805	124	C>S		No	ClinGen Ensembl
rs1553394097 CA344462377	125	F>L		No	ClinGen gnomAD
rs782004015 CA1362036	126	A>D		No	ClinGen ExAC gnomAD
CA1362035 rs782347381	126	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1553394098 CA344462396	127	E>*		No	ClinGen Ensembl
rs1013236058 CA36535243	127	E>D		No	ClinGen Ensembl
CA1362037 rs782159442	127	E>G		No	ClinGen ExAC gnomAD
CA1362038 rs782782706	128	L>*		No	ClinGen ExAC TOPMed gnomAD
rs1553394101 CA344462406	129	V>M		No	ClinGen gnomAD
CA1362040 rs782046050	131	P>A		No	ClinGen ExAC TOPMed gnomAD
rs1252611736 CA344462421	131	P>L		No	ClinGen TOPMed
CA344462425 rs1225867096	132	G>D		No	ClinGen TOPMed
TCGA novel	133	G>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs782739938 CA1362041	133	G>S		No	ClinGen ExAC TOPMed gnomAD
CA1362042 rs781816978	134	P>L		No	ClinGen ExAC gnomAD
CA36535273 rs980359268	136	W>*		No	ClinGen TOPMed
rs1344063691 CA344462454	137	C>G		No	ClinGen TOPMed gnomAD
rs1344063691 CA344462453	137	C>R		No	ClinGen TOPMed gnomAD
rs1572282680 CA344462459	137	C>W		No	ClinGen Ensembl
rs781906338 CA1362045	140	C>R		No	ClinGen ExAC gnomAD
CA36535278 rs777728322	141	G>R		No	ClinGen TOPMed gnomAD
rs1553394116 CA344462486	142	R>*		No	ClinGen Ensembl
CA344462490 rs1398712023	142	R>L		No	ClinGen TOPMed gnomAD
CA344462489 rs1398712023	142	R>P		No	ClinGen TOPMed gnomAD
rs1553394119 CA344462758	145	L>Q		No	ClinGen gnomAD
CA344462759 rs1553394124	146	R>G		No	ClinGen gnomAD
rs1372380106 CA344462762	146	R>P		No	ClinGen TOPMed gnomAD
CA344462761 rs1372380106	146	R>Q		No	ClinGen TOPMed gnomAD
rs782183659 CA1362050	148	A>E		No	ClinGen ExAC gnomAD
CA1362051 rs78394637	150	R>C		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA1362052 rs782603574	150	R>H		No	ClinGen ExAC TOPMed gnomAD
CA344462794 rs782603574	150	R>P		No	ClinGen ExAC TOPMed gnomAD
CA344462790 rs78394637	150	R>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1553394128 CA344462805	152	T>A		No	ClinGen gnomAD
CA344462808 rs1553394130	152	T>S		No	ClinGen gnomAD
TCGA novel	153	N>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA344462812 rs1553394132	153	N>Y		No	ClinGen gnomAD
CA1362061 rs781984025	154	C>Y		No	ClinGen ExAC gnomAD
CA344467656 rs1212423666	158	C>G		No	ClinGen TOPMed
CA344467700 rs1310527980	161	E>*		No	ClinGen TOPMed
rs782799384 CA1362063	163	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs781811232 CA1362065	163	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs781811232 CA1362064	163	R>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA344467752 rs1553398916	164	S>I		No	ClinGen gnomAD
CA1362066 CA344467755 rs782762921	164	S>R		No	ClinGen ExAC TOPMed gnomAD
rs1012028034 CA36548901	167	Q>H		No	ClinGen Ensembl
rs1553398921 CA344467824	169	D>V		No	ClinGen gnomAD
CA344467877 rs1553398926	172	Q>H		No	ClinGen gnomAD
CA36548912 rs1027312389	174	E>D		No	ClinGen gnomAD
CA1362067 rs781821022	175	G>C		No	ClinGen ExAC gnomAD
CA344467910 rs781821022	175	G>S		No	ClinGen ExAC gnomAD
rs1290113831 CA344467946	177	S>F		No	ClinGen TOPMed gnomAD
rs1290113831 CA344467944	177	S>Y		No	ClinGen TOPMed gnomAD
rs782638829 CA1362069	178	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA1362068 rs782524239	178	R>W		No	ClinGen ExAC TOPMed gnomAD
CA344468011 rs1572320375	183	P>Q		No	ClinGen Ensembl
CA1362070 rs369222315	183	P>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA344468083 rs782448998	186	T>I		No	ClinGen ExAC gnomAD
CA1362071 rs782448998	186	T>N		No	ClinGen ExAC gnomAD
CA344468073 rs1572320390	186	T>P		No	ClinGen Ensembl
CA1362074 rs782332110	189	V>A		No	ClinGen ExAC gnomAD
CA1362073 rs148860285	189	V>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs139992469 CA1362077	190	T>I		No	ClinGen ESP ExAC TOPMed gnomAD
rs782236204 CA1362076	190	T>P		No	ClinGen ExAC gnomAD
CA344468194 rs1157501963	193	Q>E		No	ClinGen TOPMed
CA1362079 rs782072478	193	Q>L		No	ClinGen ExAC gnomAD
CA1362139 rs782576124	196	C>R		No	ClinGen ExAC TOPMed gnomAD
rs782222502 CA1362140	196	C>Y		No	ClinGen ExAC gnomAD
rs1553406753 CA344463233	197	K>E		No	ClinGen gnomAD
rs1331153170 CA344463273	199	V>A		No	ClinGen TOPMed
CA1362143 rs545147786	200	E>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA344463327 rs1553406765	203	Q>*		No	ClinGen gnomAD
rs144335994 CA1362144	204	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
rs782012174 CA1362145	204	R>H		No	ClinGen ExAC TOPMed gnomAD
CA1362146 rs782190148	205	P>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs202049293 CA36537548	206	P>L		No	ClinGen Ensembl
rs1553406782 CA344463456	209	Q>R		No	ClinGen gnomAD
CA344463472 rs1553406784	210	E>K		No	ClinGen gnomAD
rs782785296 CA1362153	216	D>H		No	ClinGen ExAC TOPMed gnomAD
rs782785296 CA1362152	216	D>N		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	219	N>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs782797227 CA1362155	220	T>M		No	ClinGen ExAC TOPMed gnomAD
CA1362157 rs148841211	221	R>*		No	ClinGen ESP ExAC TOPMed gnomAD
rs200076913 CA1362158	221	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA1362191 rs199649479	234	G>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA1362192 rs782332000	235	T>A		No	ClinGen ExAC gnomAD
CA344464161 rs782573550	235	T>I		No	ClinGen ExAC gnomAD
CA344464158 rs782573550	235	T>N		No	ClinGen ExAC gnomAD
CA1362193 rs782573550	235	T>S		No	ClinGen ExAC gnomAD
CA344464188 rs1553407042	237	T>A		No	ClinGen gnomAD
CA344464202 rs1553407044	237	T>M		No	ClinGen gnomAD
rs782389172 CA1362195	238	G>D		No	ClinGen ExAC gnomAD
rs1553407049 CA344464264	241	K>T		No	ClinGen gnomAD
TCGA novel	242	V>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1553407052 CA344464279	242	V>L		No	ClinGen gnomAD
rs1553407057 CA344464308	243	H>R		No	ClinGen gnomAD
rs150163860 CA1362198	247	R>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA1362199 rs150163860	247	R>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs369854759 CA1362197	247	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA1362200 rs545894272	248	R>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1553407065 CA344464390	248	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA344464419 rs1553407069	250	V>L		No	ClinGen gnomAD
rs201563198 CA1362202	251	T>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs782546661 CA1362206	253	P>L		No	ClinGen ExAC gnomAD
rs910307989 CA36537863	254	A>G		No	ClinGen TOPMed
CA344464559 rs782470099	257	R>P		No	ClinGen ExAC TOPMed gnomAD
CA1362209 rs782470099	257	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs782709734 CA1362207	257	R>W		No	ClinGen ExAC gnomAD
CA36537869 rs539554161	260	S>F		No	ClinGen Ensembl
rs1553407088 CA344464604	260	S>P		No	ClinGen gnomAD
CA1362210 rs782647521	261	I>M		No	ClinGen ExAC TOPMed gnomAD
rs782553437 CA1362212	265	I>M		No	ClinGen ExAC gnomAD
rs782667123 CA1362213	267	E>Q		No	ClinGen ExAC gnomAD
CA344464781 rs1553407102	267	E>V		No	ClinGen gnomAD
rs782184864 CA1362214	269	N>K		No	ClinGen ExAC TOPMed gnomAD
CA1362217 rs782218272	271	A>V		No	ClinGen ExAC TOPMed gnomAD
rs1046688940 CA36537899	273	T>I		No	ClinGen TOPMed gnomAD
CA1362221 rs149067883	274	T>K		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA1362220 rs149067883	274	T>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA36537912 rs201417666 CA344464930	275	D>E		No	ClinGen ExAC TOPMed gnomAD
CA344464913 rs1553407114	275	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1414337712 CA344464931	276	K>Q		No	ClinGen TOPMed
TCGA novel	276	K>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs900661125 CA36537913	277	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA1362225 rs4845112	277	R>W		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA344465030 rs1572372974	281	Y>S		No	ClinGen Ensembl
CA36537915 rs932181365	285	D>N		No	ClinGen Ensembl
rs1553407134 CA344465119	288	K>Q		No	ClinGen gnomAD
rs1572373009 CA344465207	293	S>G		No	ClinGen Ensembl
rs782500219 CA1362226	294	S>G		No	ClinGen ExAC
CA344465258 rs1553407144	295	T>N		No	ClinGen gnomAD
CA1362227 rs782806231	297	T>I		No	ClinGen ExAC gnomAD
CA1362229 rs782455588	298	V>I		No	ClinGen ExAC gnomAD
CA344465319 rs1157845699	299	S>R		No	ClinGen TOPMed gnomAD
CA36537938 rs140118607	303	Q>E		No	ClinGen ESP
rs782557894 CA1362230	303	Q>P		No	ClinGen ExAC gnomAD
rs782662751 CA1362233	306	L>H		No	ClinGen ExAC gnomAD
CA1362236 rs782249472	307	K>N		No	ClinGen ExAC gnomAD
rs1553407164 CA344465426	307	K>R		No	ClinGen gnomAD
rs1185347490 CA344465444	310	M>V		No	ClinGen TOPMed
CA1362237 rs147291212	316	Q>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs200663011 CA1362238	317	K>R		No	ClinGen 1000Genomes ExAC
rs782205958 CA1362239	319	A>V		No	ClinGen ExAC gnomAD
CA36537952 rs1054565713	321	F>L		No	ClinGen Ensembl
rs782316266 CA1362240	322	K>E		No	ClinGen ExAC TOPMed gnomAD
CA1362242 rs570039354	323	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs550196205 CA1362241	323	R>W		No	ClinGen 1000Genomes ExAC gnomAD
rs1553407184 CA344465543	324	I>T		No	ClinGen gnomAD
rs1553407191 CA344465551	325	H>R		No	ClinGen gnomAD
rs1553407194 TCGA novel CA344465561	326	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen gnomAD NCI-TCGA
CA1362245 rs144913020	328	G>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA344465580 rs1558524714	329	Q>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
rs1292180361 CA344465737	330	V>A		No	ClinGen TOPMed gnomAD
rs1364776088 CA344465741	331	L>V		No	ClinGen TOPMed
CA1362276 rs782607707	333	Q>H		No	ClinGen ExAC gnomAD
rs746023356 CA36538100	335	L>P		No	ClinGen Ensembl
rs148610151 CA1362277	336	S>F		No	ClinGen ESP ExAC TOPMed gnomAD
rs782558201 CA1362278	337	I>V		No	ClinGen ExAC TOPMed gnomAD
CA1362280 rs561503861	340	R>C		No	ClinGen 1000Genomes ExAC gnomAD
CA1362281 rs782312271	340	R>H		No	ClinGen ExAC gnomAD
CA344465809 rs1553407363	342	L>I		No	ClinGen gnomAD
TCGA novel	342	L>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1572374809 CA344465818	343	Y>S		No	ClinGen Ensembl
CA1362282 rs782615062	345	R>C		No	ClinGen ExAC TOPMed gnomAD
rs782213884 CA1362283	345	R>H		No	ClinGen ExAC TOPMed gnomAD
CA344465859 rs1171545733	350	P>R		No	ClinGen TOPMed
rs782292608 CA1362286	351	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs530192428 CA1362287	352	T>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs782753442 CA1362290	354	V>I		No	ClinGen ExAC gnomAD
rs1485473538 CA344465937	362	N>D		No	ClinGen TOPMed gnomAD
CA344465959 rs1553407380	365	G>R		No	ClinGen gnomAD
rs1253444123 CA344465968	366	E>A		No	ClinGen TOPMed gnomAD
rs563800378 CA36538122	367	V>A		No	ClinGen 1000Genomes
TCGA novel	367	V>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA344466842 rs1553407747	369	W>S		No	ClinGen gnomAD
rs782145620 CA1362313	370	D>E		No	ClinGen ExAC gnomAD
TCGA novel	370	D>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA344466859 rs1553407755	371	A>G		No	ClinGen gnomAD
CA344466860 rs1553407755	371	A>V		No	ClinGen gnomAD
CA1362314 rs782710434	372	F>L		No	ClinGen ExAC gnomAD
rs374894198 CA1362315	373	S>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA36538500 rs781884773	374	I>L		No	ClinGen TOPMed gnomAD
CA344466881 rs781884773	374	I>V		No	ClinGen TOPMed gnomAD
rs150973687 CA36538516	375	P>R		No	ClinGen ESP TOPMed
rs782097670 CA1362316	379	N>H		No	ClinGen ExAC gnomAD
CA1362317 rs368719396	379	N>T		No	ClinGen ESP ExAC gnomAD
TCGA novel	381	L>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1396094779 CA344466933	381	L>V		No	ClinGen TOPMed gnomAD
CA1362319 rs782502649	388	E>K		No	ClinGen ExAC TOPMed gnomAD
rs782502649 CA344466979	388	E>Q		No	ClinGen ExAC TOPMed gnomAD
rs764844474 CA1362320	390	D>H		No	ClinGen ExAC TOPMed gnomAD
CA1362321 rs764844474	390	D>N		No	ClinGen ExAC TOPMed gnomAD
CA344467031 rs1553407773	395	V>M		No	ClinGen gnomAD
CA36538525 rs954068163	397	K>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs1553407780 CA344467054	398	K>E		No	ClinGen gnomAD
rs1553407783 CA344467072	400	D>G		No	ClinGen gnomAD
CA36538526 rs112969377	403	R>M		No	ClinGen Ensembl
CA1362324 rs782580377	404	Q>E		No	ClinGen ExAC gnomAD
rs782489549 CA1362326	407	E>A		No	ClinGen ExAC gnomAD
CA344467118 rs1448051673	407	E>K		No	ClinGen TOPMed
rs372832789 CA1362327	408	E>A		No	ClinGen ESP ExAC gnomAD
rs1553407796 CA344467143	410	L>F		No	ClinGen gnomAD
TCGA novel	415	G>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA1362328 rs782253930	415	G>R		No	ClinGen ExAC TOPMed gnomAD
CA344467192 rs1469978454	417	P>H		No	ClinGen TOPMed

No associated diseases with Q8WWW0

4 regional properties for Q8WWW0

Type	Name	Position	InterPro Accession
domain	Ras-associating domain	272 - 364	IPR000159
domain	Protein kinase C-like, phorbol ester/diacylglycerol-binding domain	122 - 171	IPR002219
domain	SARAH domain	366 - 413	IPR011524
domain	Ras association domain-containing protein 5, RA domain	207 - 362	IPR033623

Functions

		Description
EC Number
Subcellular Localization	Cytoplasm Cytoplasm, cytoskeleton	Isoform 2 is mainly located in the perinuclear region of unstimulated primary T-cells Upon stimulation translocates to the leading edge and colocalizes with ITGAL/LFA-1 in the peripheral zone of the immunological synapse Isoform 2 is localized to growing microtubules in vascular endothelial cells and is dissociated from microtubules by activated RAP1A
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

3 GO annotations of cellular component

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
microtubule	Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

3 GO annotations of molecular function

Name	Definition
identical protein binding	Binding to an identical protein or proteins.
metal ion binding	Binding to a metal ion.
small GTPase binding	Binding to a small monomeric GTPase.

7 GO annotations of biological process

Name	Definition
apoptotic process	A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
lymphocyte proliferation	The expansion of a lymphocyte population by cell division.
negative regulation of lymphocyte proliferation	Any process that stops, prevents or reduces the rate or extent of lymphocyte proliferation.
positive regulation of protein ubiquitination	Any process that activates or increases the frequency, rate or extent of the addition of ubiquitin groups to a protein.
regulation of apoptotic process	Any process that modulates the occurrence or rate of cell death by apoptotic process.
regulation of protein localization to nucleus	Any process that modulates the frequency, rate or extent of protein localization to nucleus.
signal transduction	The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.

7 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q6ZTQ3	RASSF6	Ras association domain-containing protein 6	Homo sapiens (Human)	PR
Q9NS23	RASSF1	Ras association domain-containing protein 1	Homo sapiens (Human)	PR
Q80UQ2	Rassf6	Ras association domain-containing protein 6	Mus musculus (Mouse)	PR
Q99MK9	Rassf1	Ras association domain-containing protein 1	Mus musculus (Mouse)	PR
Q5EBH1	Rassf5	Ras association domain-containing protein 5	Mus musculus (Mouse)	PR
Q4QR82	Rassf6	Ras association domain-containing protein 6	Rattus norvegicus (Rat)	PR
O35141	Rassf5	Ras association domain-containing protein 5	Rattus norvegicus (Rat)	PR

10	20	30	40	50	60
MAMASPAIGQ	RPYPLLLDPE	PPRYLQSLSG	PELPPPPPDR	SSRLCVPAPL	STAPGAREGR
70	80	90	100	110	120
SARRAARGNL	EPPPRASRPA	RPLRPGLQQR	LRRRPGAPRP	RDVRSIFEQP	QDPRVPAERG
130	140	150	160	170	180
EGHCFAELVL	PGGPGWCDLC	GREVLRQALR	CTNCKFTCHP	ECRSLIQLDC	SQQEGLSRDR
190	200	210	220	230	240
PSPESTLTVT	FSQNVCKPVE	ETQRPPTLQE	IKQKIDSYNT	REKNCLGMKL	SEDGTYTGFI
250	260	270	280	290	300
KVHLKLRRPV	TVPAGIRPQS	IYDAIKEVNL	AATTDKRTSF	YLPLDAIKQL	HISSTTTVSE
310	320	330	340	350	360
VIQGLLKKFM	VVDNPQKFAL	FKRIHKDGQV	LFQKLSIADR	PLYLRLLAGP	DTEVLSFVLK
370	380	390	400	410
ENETGEVEWD	AFSIPELQNF	LTILEKEEQD	KIQQVQKKYD	KFRQKLEEAL	RESQGKPG