Q99ME6
Gene name |
Atp1b4 |
Protein name |
Protein ATP1B4 |
Names |
X,K-ATPase subunit beta-m, X/potassium-transporting ATPase subunit beta-m |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:67821 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q99ME6
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q99ME6-F1 | Predicted | AlphaFoldDB |
18 variants for Q99ME6
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389536178 | 48 | V>M | No | EVA | |
| rs3389566261 | 61 | K>E | No | EVA | |
| rs3389549653 | 94 | D>N | No | EVA | |
| rs3389557694 | 98 | R>S | No | EVA | |
| rs3412660163 | 103 | R>* | No | EVA | |
| rs3389553142 | 113 | V>L | No | EVA | |
| rs3389536135 | 125 | V>M | No | EVA | |
| rs3389572304 | 153 | V>F | No | EVA | |
| rs3409773305 | 191 | S>N | No | EVA | |
| rs3389465179 | 214 | E>D | No | EVA | |
| rs1133213451 | 248 | L>F | No | EVA | |
| rs3389523651 | 280 | S>T | No | EVA | |
| rs3389551843 | 316 | T>I | No | EVA | |
| rs3409923054 | 319 | V>* | No | EVA | |
| rs1132471370 | 328 | C>Y | No | EVA | |
| rs1132773615 | 329 | Q>H | No | EVA | |
| rs1134856939 | 331 | K>N | No | EVA | |
| rs1134793983 | 332 | G>V | No | EVA |
No associated diseases with Q99ME6
1 regional properties for Q99ME6
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Serine aminopeptidase, S33 | 117 - 226 | IPR022742 |
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| chromatin | The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome. |
| nuclear envelope | The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space). |
| nuclear inner membrane | The inner, i.e. lumen-facing, lipid bilayer of the nuclear envelope. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| sodium:potassium-exchanging ATPase complex | Sodium:potassium-exchanging ATPases are tetrameric proteins, consisting of two large alpha subunits and two smaller beta subunits. The alpha subunits bear the active site and penetrate the membrane, while the beta subunits carry oligosaccharide groups and face the cell exterior. |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| potassium ion transport | The directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| regulation of DNA-templated transcription | Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. |
| sodium ion transport | The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
4 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P08251 | ATP1B1 | Sodium/potassium-transporting ATPase subunit beta-1 | Gallus gallus (Chicken) | PR |
| Q9UN42 | ATP1B4 | Protein ATP1B4 | Homo sapiens (Human) | PR |
| P05027 | ATP1B1 | Sodium/potassium-transporting ATPase subunit beta-1 | Sus scrofa (Pig) | PR |
| Q9R193 | Atp1b4 | Protein ATP1B4 | Rattus norvegicus (Rat) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MRRQLRSRRA | PAFPYGYRYR | LDDQDEANHN | YLADEEEEAE | EEAQVMMVPG | LEEEEEEEEG |
| 70 | 80 | 90 | 100 | 110 | 120 |
| KEEEEEREEE | EGQGQSTGSA | WWRKLQIVNE | YLWDPEKRMS | LARTGQSRSL | ILVIYFFFYA |
| 130 | 140 | 150 | 160 | 170 | 180 |
| SLAAVITLFI | YMLFLAISPY | MPTFTEQVKP | PGVMIRPFAH | SLNFNFNVSE | PETWQRYVIS |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LNGFLQGYND | SLQEEMNIDC | PPGRYFIQDG | DEDEDKKACQ | FKRSFLKNCS | GLEDPTFGYS |
| 250 | 260 | 270 | 280 | 290 | 300 |
| TGQPCILLKM | NRIVGFRPEF | GDPVKVSCKV | QKGDENDIRS | INYYPESASF | DLRYYPYYGK |
| 310 | 320 | 330 | 340 | 350 | |
| LTHVNYTSPL | VAMHFTDVVK | NQAVPVQCQL | KGKGIVNDVI | NDRFVGRIIF | TLNIET |