P05027

PR
Gene name
ATP1B1
Protein name
Sodium/potassium-transporting ATPase subunit beta-1
Names
Sodium/potassium-dependent ATPase subunit beta-1
Species
Sus scrofa (Pig)
KEGG Pathway
ssc:396898
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

45-170 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

27 structures for P05027

Entry ID Method Resolution Chain Position Source
3B8E X-ray 350 A B/D 28-73 PDB
3KDP X-ray 350 A B/D 18-303 PDB
3N23 X-ray 460 A B/D 27-303 PDB
3WGU X-ray 280 A B/D 1-303 PDB
3WGV X-ray 280 A B/D 1-303 PDB
4HQJ X-ray 430 A B/D 1-303 PDB
4HYT X-ray 340 A B/D 1-303 PDB
4RES X-ray 341 A B/D 1-303 PDB
4RET X-ray 400 A B/D 1-303 PDB
7D91 X-ray 335 A B 1-303 PDB
7D92 X-ray 390 A B 1-303 PDB
7D93 X-ray 365 A B/D 1-303 PDB
7D94 X-ray 350 A B/D 1-303 PDB
7DDF X-ray 462 A B/D 1-303 PDB
7DDH X-ray 346 A B/D 1-303 PDB
7DDI X-ray 372 A B/D 1-303 PDB
7DDK X-ray 350 A B/D 1-303 PDB
7DDL X-ray 320 A B/D 1-303 PDB
7QTV X-ray 405 A B/D 1-303 PDB
7WYS X-ray 371 A B/D 1-303 PDB
7WYT X-ray 290 A B/D 1-303 PDB
7YZR X-ray 692 A B/D 2-303 PDB
7Z04 X-ray 750 A B/D 2-303 PDB
8JBK X-ray 280 A B/D 1-303 PDB
8JBL X-ray 300 A B/D 1-303 PDB
8JBM X-ray 290 A B/D 1-303 PDB
AF-P05027-F1 Predicted AlphaFoldDB

5 variants for P05027

Variant ID(s) Position Change Description Diseaes Association Provenance
rs697022485 90 F>L No EVA
rs698699199 130 P>H No EVA
rs3474352401 169 Y>* No EVA
rs344930215 198 T>S No EVA
rs3471499272 204 Y>F No EVA

No associated diseases with P05027

No regional properties for P05027

Type Name Position InterPro Accession
No domain, repeats, and functional sites for P05027

Functions

Description
EC Number
Subcellular Localization
  • Cell membrane ; Single-pass type II membrane protein
  • Apical cell membrane ; Single-pass type II membrane protein
  • Cell membrane, sarcolemma
  • Colocalizes with OBSCN at the intercalated disk and sarcolemma in cardiomyocytes
  • Localizes in long striations at the level of Z and M lines
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

8 GO annotations of cellular component

Name Definition
apical plasma membrane The region of the plasma membrane located at the apical end of the cell.
basolateral plasma membrane The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.
intercalated disc A complex cell-cell junction at which myofibrils terminate in cardiomyocytes; mediates mechanical and electrochemical integration between individual cardiomyocytes. The intercalated disc contains regions of tight mechanical attachment (fasciae adherentes and desmosomes) and electrical coupling (gap junctions) between adjacent cells.
lateral plasma membrane The portion of the plasma membrane at the lateral side of the cell. In epithelial cells, lateral plasma membranes are on the sides of cells which lie at the interface of adjacent cells.
organelle membrane A membrane that is one of the two lipid bilayers of an organelle envelope or the outermost membrane of single membrane bound organelle.
sodium:potassium-exchanging ATPase complex Sodium:potassium-exchanging ATPases are tetrameric proteins, consisting of two large alpha subunits and two smaller beta subunits. The alpha subunits bear the active site and penetrate the membrane, while the beta subunits carry oligosaccharide groups and face the cell exterior.
sperm flagellum A microtubule-based flagellum (or cilium) that is part of a sperm, a mature male germ cell that develops from a spermatid.
T-tubule Invagination of the plasma membrane of a muscle cell that extends inward from the cell surface around each myofibril. The ends of T-tubules make contact with the sarcoplasmic reticulum membrane.

5 GO annotations of molecular function

Name Definition
ATPase activator activity Binds to and increases the activity of an ATP hydrolysis activity.
ATPase binding Binding to an ATPase, any enzyme that catalyzes the hydrolysis of ATP.
protein C-terminus binding Binding to a protein C-terminus, the end of a peptide chain at which the 1-carboxyl function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue.
protein kinase binding Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
protein-macromolecule adaptor activity The binding activity of a protein that brings together two or more macromolecules in contact, permitting those molecules to function in a coordinated way. The adaptor can bring together two proteins, or a protein and another macromolecule such as a lipid or a nucleic acid.

22 GO annotations of biological process

Name Definition
ATP metabolic process The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator.
cardiac muscle contraction Muscle contraction of cardiac muscle tissue.
cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
cellular calcium ion homeostasis Any process involved in the maintenance of an internal steady state of calcium ions at the level of a cell.
cellular potassium ion homeostasis Any process involved in the maintenance of an internal steady state of potassium ions at the level of a cell.
cellular sodium ion homeostasis Any process involved in the maintenance of an internal steady state of sodium ions at the level of a cell.
establishment or maintenance of transmembrane electrochemical gradient The directed movement of ions to establish or maintain an electrochemical gradient across a membrane by means of some agent such as a transporter or pore.
innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.
membrane repolarization The process in which ions are transported across a membrane such that the membrane potential changes in the repolarizing direction, toward the steady state potential. For example, the repolarization during an action potential is from a positive membrane potential towards a negative resting potential.
positive regulation of calcium:sodium antiporter activity Any process that activates or increases the frequency, rate or extent of calcium:sodium antiporter activity.
positive regulation of P-type sodium:potassium-exchanging transporter activity Any process that activates or increases the frequency, rate or extent of sodium:potassium-exchanging ATPase activity.
positive regulation of potassium ion import across plasma membrane Any process that activates or increases the frequency, rate or extent of potassium ion import across the plasma membrane.
positive regulation of sodium ion export across plasma membrane Any process that activates or increases the frequency, rate or extent of sodium ion export across the plasma membrane.
potassium ion import across plasma membrane The directed movement of potassium ions from outside of a cell, across the plasma membrane and into the cytosol.
protein localization to plasma membrane A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane.
protein stabilization Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation.
proton transmembrane transport The directed movement of a proton across a membrane.
regulation of cardiac muscle contraction by calcium ion signaling Any process that modulates the frequency, rate or extent of cardiac muscle contraction by changing the calcium ion signals that trigger contraction.
regulation of gene expression Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA).
relaxation of cardiac muscle The process in which the extent of cardiac muscle contraction is reduced.
sodium ion export across plasma membrane The directed movement of sodium ions from inside of a cell, across the plasma membrane and into the extracellular region.
transmembrane transport The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.

4 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P08251 ATP1B1 Sodium/potassium-transporting ATPase subunit beta-1 Gallus gallus (Chicken) PR
Q9UN42 ATP1B4 Protein ATP1B4 Homo sapiens (Human) PR
Q99ME6 Atp1b4 Protein ATP1B4 Mus musculus (Mouse) PR
Q9R193 Atp1b4 Protein ATP1B4 Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MARGKAKEEG SWKKFIWNSE KKEFLGRTGG SWFKILLFYV IFYGCLAGIF IGTIQVMLLT
70 80 90 100 110 120
ISEFKPTYQD RVAPPGLTQI PQSQKTEISF RPNDPQSYES YVVSIVRFLE KYKDLAQKDD
130 140 150 160 170 180
MIFEDCGNVP SELKERGEYN NERGERKVCR FRLEWLGNCS GLNDETYGYK DGKPCVIIKL
190 200 210 220 230 240
NRVLGFKPKP PKNESLETYP VMKYNPYVLP VHCTGKRDED KEKVGTMEYF GLGGYPGFPL
250 260 270 280 290 300
QYYPYYGKLL QPKYLQPLMA VQFTNLTMDT EIRIECKAYG ENIGYSEKDR FQGRFDVKIE
VKS