AiPD: Autoinhibited Protein Database

Gene name	Eps8l2 (Eps8r2)
Protein name	Epidermal growth factor receptor kinase substrate 8-like protein 2
Names	EPS8-like protein 2, Epidermal growth factor receptor pathway substrate 8-related protein 2, EPS8-related protein 2
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:98845
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

150-222 (Predicted disordered autoinhibitory region) PR

150-222 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q99K30-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs3412926984	11	P>L	No	EVA
rs3388944762	13	A>T	No	EVA
rs3388958657	27	M>K	No	EVA
rs3388932664	39	Y>F	No	EVA
rs3388955795	54	V>M	No	EVA
rs3388955187	92	V>I	No	EVA
rs220262610	98	D>N	No	EVA
rs3411928441	112	L>P	No	EVA
rs3388938443	122	H>D	No	EVA
rs3388959749	141	Q>H	No	EVA
rs3388959844	157	E>D	No	EVA
rs3388959714	199	L>I	No	EVA
rs3388962782	208	I>L	No	EVA
rs248229924	236	G>A	No	EVA
rs3388955221	305	L>H	No	EVA
rs3388932613	314	E>G	No	EVA
rs3388938504	319	D>E	No	EVA
rs3388955773	320	C>Y	No	EVA
rs3388948457	324	T>P	No	EVA
rs3388955771	356	L>M	No	EVA
rs3388962376	360	T>I	No	EVA
rs3411505396	375	L>V	No	EVA
rs3388958656	389	P>S	No	EVA
rs3388932621	430	L>P	No	EVA
rs3388959842	476	D>V	No	EVA
rs243297528	477	I>N	No	EVA
rs258134016	480	P>A	No	EVA
rs225384065	480	P>L	No	EVA
rs258379319	489	G>S	No	EVA
rs263045959	557	V>M	No	EVA
rs3388962771	568	Y>*	No	EVA
rs252727954	634	D>E	No	EVA
rs3388964744	666	K>N	No	EVA
rs3388955825	668	E>K	No	EVA
rs3388955828	689	A>T	No	EVA

Type	Name	Position	InterPro Accession
domain	SH3 domain	495 - 554	IPR001452
domain	PTB/PI domain	47 - 184	IPR006020
domain	Tensin/EPS8 phosphotyrosine-binding domain	51 - 181	IPR013625
domain	Epidermal growth factor receptor kinase substrate, phosphotyrosine-binding domain	48 - 178	IPR033928
domain	Eps8, SH3 domain	499 - 549	IPR035462
domain	SAM domain	626 - 685	IPR041418

		Description
EC Number
Subcellular Localization	Cytoplasm Cell projection, stereocilium	Localizes at the tips of the stereocilia of the inner and outer hair cells
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
protein-containing complex	A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
ruffle	Projection at the leading edge of a crawling cell; the protrusions are supported by a microfilament meshwork.
ruffle membrane	The portion of the plasma membrane surrounding a ruffle.
stereocilium bundle	A bundle of cross-linked stereocilia, arranged around a kinocilium on the apical surface of a sensory hair cell (e.g. a neuromast, auditory or vestibular hair cell). Stereocilium bundles act as mechanosensory organelles by responding to fluid motion or fluid pressure changes.
stereocilium tip	A distinct compartment at the tip of a stereocilium, distal to the site of attachment to the apical cell surface. It consists of a dense matrix bridging the barbed ends of the stereocilium actin filaments with the overlying plasma membrane, is dynamic compared to the shaft, and is required for stereocilium elongation.

Name	Definition
actin binding	Binding to monomeric or multimeric forms of actin, including actin filaments.
actin filament binding	Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits.
guanyl-nucleotide exchange factor activity	Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions.

Name	Definition
positive regulation of ruffle assembly	Any process that activates or increases the frequency, rate or extent of ruffle assembly.
Rac protein signal transduction	The series of molecular signals within the cell that are mediated by a member of the Rac family of proteins switching to a GTP-bound active state.
regulation of Rho protein signal transduction	Any process that modulates the frequency, rate or extent of Rho protein signal transduction.
Rho protein signal transduction	The series of molecular signals within the cell that are mediated by a member of the Rho family of proteins switching to a GTP-bound active state.
sensory perception of sound	The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q8TE67	EPS8L3	Epidermal growth factor receptor kinase substrate 8-like protein 3	Homo sapiens (Human)	PR
Q8TE68	EPS8L1	Epidermal growth factor receptor kinase substrate 8-like protein 1	Homo sapiens (Human)	PR
Q9H6S3	EPS8L2	Epidermal growth factor receptor kinase substrate 8-like protein 2	Homo sapiens (Human)	PR
Q8R5F8	Eps8l1	Epidermal growth factor receptor kinase substrate 8-like protein 1	Mus musculus (Mouse)	PR
Q91WL0	Eps8l3	Epidermal growth factor receptor kinase substrate 8-like protein 3	Mus musculus (Mouse)	PR
Q08509	Eps8	Epidermal growth factor receptor kinase substrate 8	Mus musculus (Mouse)	PR