Q8R5F8
PR
Gene name |
Eps8l1 (Eps8r1) |
Protein name |
Epidermal growth factor receptor kinase substrate 8-like protein 1 |
Names |
EPS8-like protein 1, Epidermal growth factor receptor pathway substrate 8-related protein 1, EPS8-related protein 1 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:67425 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
3 structures for Q8R5F8
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 2CY4 | X-ray | 194 A | A | 26-165 | PDB |
| 2CY5 | X-ray | 190 A | A | 26-165 | PDB |
| AF-Q8R5F8-F1 | Predicted | AlphaFoldDB |
45 variants for Q8R5F8
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388855015 | 3 | T>S | No | EVA | |
| rs3388871109 | 28 | V>A | No | EVA | |
| rs3388859045 | 40 | H>N | No | EVA | |
| rs3388879516 | 44 | F>S | No | EVA | |
| rs3388849523 | 47 | G>E | No | EVA | |
| rs3388871422 | 73 | A>T | No | EVA | |
| rs3388859070 | 101 | L>F | No | EVA | |
| rs50309745 | 130 | A>V | No | EVA | |
| rs3388863443 | 133 | D>H | No | EVA | |
| rs3388874912 | 148 | R>C | No | EVA | |
| rs3388859069 | 171 | R>W | No | EVA | |
| rs3388849467 | 237 | P>H | No | EVA | |
| rs231575637 | 239 | S>Y | No | EVA | |
| rs3388875427 | 242 | L>* | No | EVA | |
| rs231094646 | 270 | S>T | No | EVA | |
| rs3388876500 | 276 | Q>P | No | EVA | |
| rs3388876825 | 283 | R>W | No | EVA | |
| rs3388875403 | 284 | V>D | No | EVA | |
| rs250303854 | 298 | A>T | No | EVA | |
| rs3388866612 | 317 | T>A | No | EVA | |
| rs48017896 | 328 | S>N | No | EVA | |
| rs3388874924 | 359 | T>I | No | EVA | |
| rs49090054 | 366 | A>S | No | EVA | |
| rs3388876504 | 373 | H>Q | No | EVA | |
| rs244253222 | 386 | V>A | No | EVA | |
| rs240742707 | 396 | S>L | No | EVA | |
| rs3397196117 | 418 | P>R | No | EVA | |
| rs3388876474 | 434 | R>H | No | EVA | |
| rs241797976 | 489 | Q>E | No | EVA | |
| rs3388863467 | 491 | R>L | No | EVA | |
| rs3397192033 | 518 | D>N | No | EVA | |
| rs3388836171 | 525 | Y>F | No | EVA | |
| rs3388871130 | 528 | Y>N | No | EVA | |
| rs3388859063 | 542 | S>N | No | EVA | |
| rs224806251 | 546 | A>T | No | EVA | |
| rs3388866576 | 549 | L>V | No | EVA | |
| rs3388879438 | 553 | T>I | No | EVA | |
| rs3388854990 | 568 | R>Q | No | EVA | |
| rs3388859042 | 577 | L>V | No | EVA | |
| rs3388879494 | 594 | V>I | No | EVA | |
| rs223038843 | 612 | V>L | No | EVA | |
| rs3388863484 | 656 | Q>* | No | EVA | |
| rs3388876804 | 656 | Q>R | No | EVA | |
| rs3388871430 | 671 | E>* | No | EVA | |
| rs3397192065 | 714 | E>V | No | EVA |
No associated diseases with Q8R5F8
No regional properties for Q8R5F8
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q8R5F8 | |||
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| protein-containing complex | A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together. |
| ruffle | Projection at the leading edge of a crawling cell; the protrusions are supported by a microfilament meshwork. |
| ruffle membrane | The portion of the plasma membrane surrounding a ruffle. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| actin binding | Binding to monomeric or multimeric forms of actin, including actin filaments. |
| actin filament binding | Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits. |
| guanyl-nucleotide exchange factor activity | Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions. |
| T cell receptor binding | Binding to a T cell receptor, the antigen-recognizing receptor on the surface of T cells. |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| positive regulation of ruffle assembly | Any process that activates or increases the frequency, rate or extent of ruffle assembly. |
| Rac protein signal transduction | The series of molecular signals within the cell that are mediated by a member of the Rac family of proteins switching to a GTP-bound active state. |
| regulation of Rho protein signal transduction | Any process that modulates the frequency, rate or extent of Rho protein signal transduction. |
| Rho protein signal transduction | The series of molecular signals within the cell that are mediated by a member of the Rho family of proteins switching to a GTP-bound active state. |
6 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q8TE67 | EPS8L3 | Epidermal growth factor receptor kinase substrate 8-like protein 3 | Homo sapiens (Human) | PR |
| Q9H6S3 | EPS8L2 | Epidermal growth factor receptor kinase substrate 8-like protein 2 | Homo sapiens (Human) | PR |
| Q8TE68 | EPS8L1 | Epidermal growth factor receptor kinase substrate 8-like protein 1 | Homo sapiens (Human) | PR |
| Q08509 | Eps8 | Epidermal growth factor receptor kinase substrate 8 | Mus musculus (Mouse) | PR |
| Q91WL0 | Eps8l3 | Epidermal growth factor receptor kinase substrate 8-like protein 3 | Mus musculus (Mouse) | PR |
| Q99K30 | Eps8l2 | Epidermal growth factor receptor kinase substrate 8-like protein 2 | Mus musculus (Mouse) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSTTTGPEAA | PKPSAKSIYE | QRKRYSTVVM | ADVSQYHVNH | LVTFCLGEED | GVHTVEDASR |
| 70 | 80 | 90 | 100 | 110 | 120 |
| KLAVMDSQGR | VWAQEMLLRV | SPSQVTLLDP | VSKEELESYP | LDAIVRCDAV | MPRGRSRSLL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LLVCQEPERA | QPDVHFFQGL | LLGAELIRED | IQGALQNYRS | GRGERRAAAL | RATQEELRRG |
| 190 | 200 | 210 | 220 | 230 | 240 |
| ASPAAETPPL | QRRPSVRLVI | NTVEPSAVRG | RPQVESIPET | EEARKPDQAR | TTSSADPTSP |
| 250 | 260 | 270 | 280 | 290 | 300 |
| DLGPRGPELA | GLQAERDVDI | LNHVFDDVES | FVSRLQKSAE | ATRVLEHRER | GRRTRRRAAG |
| 310 | 320 | 330 | 340 | 350 | 360 |
| EGLLTLRAKP | PTEAEYTDVL | QKIKYAFSLL | ARLRGNIANP | SSPELLHFLF | GPLQMIVNTS |
| 370 | 380 | 390 | 400 | 410 | 420 |
| GGPEFAKSVR | RPHLTLEAVT | LLRDNVTPGE | NELWTSLGDS | WTCPGVELPP | EEGSPYSPEF |
| 430 | 440 | 450 | 460 | 470 | 480 |
| YNGWEPPATD | PQGRPWEDPV | EKQLQHEKRR | RQQSAPQVAV | NGQQDPELET | ESQLEEKARK |
| 490 | 500 | 510 | 520 | 530 | 540 |
| WVLCNYDFQA | RNGSELSVKH | RDVLEVLDDR | RKWWKVRDHQ | GQEGYVPYNI | LTPHPGPQVH |
| 550 | 560 | 570 | 580 | 590 | 600 |
| RSQSPARHLE | TSTPPPPPAP | APAPTQVRPQ | WDSCDSLNSL | DPSEKEKFSQ | MLCVNEELQS |
| 610 | 620 | 630 | 640 | 650 | 660 |
| RLAQGRSGPS | RVTPGPRAQE | PQLSPRSEAS | VVRAWLQTKG | FSSGTVEALG | VLTGAQLFSL |
| 670 | 680 | 690 | 700 | 710 | |
| QKEELRAVCP | EEGARVYSQV | TVQRALLEDR | EKVSELEAVM | EKQKKKVEGE | TKTEVI |