Q91WL0
Gene name |
Eps8l3 (Eps8r3) |
Protein name |
Epidermal growth factor receptor kinase substrate 8-like protein 3 |
Names |
EPS8-like protein 3, Epidermal growth factor receptor pathway substrate 8-related protein 3, EPS8-related protein 3 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:99662 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q91WL0
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q91WL0-F1 | Predicted | AlphaFoldDB |
26 variants for Q91WL0
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388652423 | 11 | L>M | No | EVA | |
| rs3393469842 | 22 | S>P | No | EVA | |
| rs3393461492 | 69 | F>V | No | EVA | |
| rs3388657044 | 136 | A>T | No | EVA | |
| rs3388657857 | 162 | P>T | No | EVA | |
| rs216151686 | 176 | L>F | No | EVA | |
| rs232887080 | 200 | H>L | No | EVA | |
| rs3388651995 | 209 | S>L | No | EVA | |
| rs3388661088 | 218 | Y>N | No | EVA | |
| rs3413026310 | 221 | A>P | No | EVA | |
| rs223757012 | 222 | R>G | No | EVA | |
| rs3388649991 | 267 | Q>* | No | EVA | |
| rs3388645714 | 282 | K>E | No | EVA | |
| rs3388652011 | 283 | K>R | No | EVA | |
| rs221398674 | 286 | N>D | No | EVA | |
| rs3388655329 | 296 | C>* | No | EVA | |
| rs3393252209 | 300 | I>L | No | EVA | |
| rs242434356 | 301 | K>N | No | EVA | |
| rs3388656035 | 360 | Q>* | No | EVA | |
| rs3388655226 | 372 | K>N | No | EVA | |
| rs255290760 | 410 | M>I | No | EVA | |
| rs3388660225 | 421 | R>* | No | EVA | |
| rs29595560 | 439 | H>R | No | EVA | |
| rs3388655332 | 454 | S>I | No | EVA | |
| rs3388651967 | 454 | S>R | No | EVA | |
| rs3388661052 | 456 | G>A | No | EVA |
No associated diseases with Q91WL0
1 regional properties for Q91WL0
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | AP2/ERF domain | 34 - 98 | IPR001471 |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| ruffle membrane | The portion of the plasma membrane surrounding a ruffle. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| actin binding | Binding to monomeric or multimeric forms of actin, including actin filaments. |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| positive regulation of ruffle assembly | Any process that activates or increases the frequency, rate or extent of ruffle assembly. |
| regulation of hair cycle | Any process that modulates the frequency, rate or extent of the cyclical phases of growth (anagen), regression (catagen), quiescence (telogen), and shedding (exogen) in the life of a hair. |
| regulation of Rho protein signal transduction | Any process that modulates the frequency, rate or extent of Rho protein signal transduction. |
| Rho protein signal transduction | The series of molecular signals within the cell that are mediated by a member of the Rho family of proteins switching to a GTP-bound active state. |
6 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q8TE68 | EPS8L1 | Epidermal growth factor receptor kinase substrate 8-like protein 1 | Homo sapiens (Human) | PR |
| Q9H6S3 | EPS8L2 | Epidermal growth factor receptor kinase substrate 8-like protein 2 | Homo sapiens (Human) | PR |
| Q8TE67 | EPS8L3 | Epidermal growth factor receptor kinase substrate 8-like protein 3 | Homo sapiens (Human) | PR |
| Q08509 | Eps8 | Epidermal growth factor receptor kinase substrate 8 | Mus musculus (Mouse) | PR |
| Q8R5F8 | Eps8l1 | Epidermal growth factor receptor kinase substrate 8-like protein 1 | Mus musculus (Mouse) | PR |
| Q99K30 | Eps8l2 | Epidermal growth factor receptor kinase substrate 8-like protein 2 | Mus musculus (Mouse) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSRPSSRAIY | LHRKEYSQSM | ASEPTLLQHR | VEHLMTCKLG | TQRVREPKDA | LQKLQEMDAQ |
| 70 | 80 | 90 | 100 | 110 | 120 |
| GRVWSQDLFL | QVRDGWLHLL | DIETKEELDS | YRLDNIKAID | VALNTCSYNS | ILSVTVQESG |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LPGISTLLFQ | CQEVGAEQLR | TSLQKALEEE | LEERPRFGVH | HPSQDRWKGP | PLERPLPIQQ |
| 190 | 200 | 210 | 220 | 230 | 240 |
| APPLEQRFSP | EHRFPPEQPH | NMTSERSISP | SSRSLTHYPS | AREPNGFTLP | PPPRRAPSPE |
| 250 | 260 | 270 | 280 | 290 | 300 |
| DPERDEEVLN | HVLRDIELFA | GKLKEVQARN | SHKKTKLGRK | KKKSKNGITQ | AEYIDCFQKI |
| 310 | 320 | 330 | 340 | 350 | 360 |
| KLSFNLLGKL | ALRMQETSAP | EFVGLIFQTL | KFILSQCPEA | GLPAKVISPL | LTPKAIDLLQ |
| 370 | 380 | 390 | 400 | 410 | 420 |
| SCLSPPEDTL | WKSLGTSWTT | SWADWTGSEP | PPYQPTFYDG | WQIPQPRSMM | PITNQDSISL |
| 430 | 440 | 450 | 460 | 470 | 480 |
| RGSRMRSSLH | FPRDEPYNHN | PEYEDSNLPL | SSPSPGRAAL | KMQVLYEFEA | RNAQELTVAQ |
| 490 | 500 | 510 | 520 | 530 | 540 |
| GEILEVLDQS | KRWWLVKNEA | GLTGYIPSNI | LEPLPAGAPR | GHRQPSFRAP | MLRLSSKPEE |
| 550 | 560 | 570 | 580 | 590 | |
| VTAWLQAENF | STVTVRTLGS | LMGSQLLHMR | PGELQMLCPQ | EAPRIQARLD | AVRRMLGMTH |