Q99287

PR
Gene name
SEY1
Protein name
Protein SEY1
Names
Synthetic enhancer of YOP1 protein
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YOR165W
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

33-146 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q99287

Entry ID Method Resolution Chain Position Source
AF-Q99287-F1 Predicted AlphaFoldDB

12 variants for Q99287

Variant ID(s) Position Change Description Diseaes Association Provenance
s15-644570 2 A>T No SGRP
s15-644579 5 P>S No SGRP
s15-645673 369 K>N No SGRP
s15-645872 436 I>V No SGRP
s15-645935 457 R>C No SGRP
s15-645972 469 K>R No SGRP
s15-646283 573 E>K No SGRP
s15-646328 588 A>T No SGRP
s15-646464 633 R>Q No SGRP
s15-646494 643 R>L No SGRP
s15-646599 678 T>I No SGRP
s15-646766 734 V>I No SGRP

No associated diseases with Q99287

4 regional properties for Q99287

Type Name Position InterPro Accession
domain Cullin, N-terminal 20 - 668 IPR001373
conserved_site Cullin, conserved site 747 - 774 IPR016157
domain Cullin homology domain 416 - 647 IPR016158
domain Cullin protein, neddylation domain 701 - 768 IPR019559

Functions

Description
EC Number
Subcellular Localization
  • Endoplasmic reticulum membrane ; Multi-pass membrane protein
  • Enriched in the cortical ER
  • Concentrated in punctae along the ER tubules
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

7 GO annotations of cellular component

Name Definition
cell periphery The part of a cell encompassing the cell cortex, the plasma membrane, and any external encapsulating structures.
cellular bud A protuberance from a cell of an organism that reproduces by budding, which will grow larger and become a separate daughter cell after nuclear division, cytokinesis, and cell wall formation (when appropriate). The daughter cell may completely separate from the mother cell, or the mother and daughter cells may remain associated.
cortical endoplasmic reticulum A cortical network of highly dynamic tubules that are juxtaposed to the plasma membrane and undergo ring closure and tubule-branching movements.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

2 GO annotations of molecular function

Name Definition
GTP binding Binding to GTP, guanosine triphosphate.
GTPase activity Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate.

4 GO annotations of biological process

Name Definition
endoplasmic reticulum inheritance The partitioning of endoplasmic reticulum between daughter cells at cell division.
endoplasmic reticulum membrane fusion The joining of 2 or more lipid bilayer membranes that surround the endoplasmic reticulum.
endoplasmic reticulum organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endoplasmic reticulum.
membrane organization A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q0JLS6 RHD3 Protein ROOT HAIR DEFECTIVE 3 Oryza sativa subsp japonica (Rice) PR
Q9SSN0 At1g72960 Protein ROOT HAIR DEFECTIVE 3 homolog 1 Arabidopsis thaliana (Mouse-ear cress) PR
P93042 NAT4 Protein ROOT HAIR DEFECTIVE 3 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MADRPAIQLI DEEKEFHQSA LQYFQQCIGN RDVGLDYHVI SVFGSQSSGK STLLNVLFNT
70 80 90 100 110 120
NFDTMDAQVK RQQTTKGIWL AHTKQVNTTI EIDNDRPDIF VLDVEGSDGS ERGEDQDFER
130 140 150 160 170 180
KAALFAIAVS EVLIVNMWEQ QIGLYQGNNM ALLKTVFEVN LSLFGKNDND HKVLLLFVIR
190 200 210 220 230 240
DHVGVTPLSS LSDSVTRELE KIWTELSKPA GCEGSSLYDY FDLKFVGLAH KLLQEDKFTQ
250 260 270 280 290 300
DVKKLGDSFV MKGTENYYFK PQYHHRLPLD GWTMYAENCW DQIERNKDLD LPTQQILVAR
310 320 330 340 350 360
FKTEEISNEA LEEFISKYDE SIAPLKGNLG SLTSQLVKLK EECLTKYDEQ ASRYARNVYM
370 380 390 400 410 420
EKREALNTKL NSHISGTINE FLESLMEKLW DDLKLEVSSR DKATTSFVES VAAGKSKIEK
430 440 450 460 470 480
EFNESMETFK KLGLLISNEE ITCKFSDDIE ERIKQLRDAE LKAKIGRIKK NLVPELKDHV
490 500 510 520 530 540
IHLLSHPSKK VWDDIMNDFE STIKDNISAY QVEKDKYDFK IGLSESENAK IYKNIRILAW
550 560 570 580 590 600
RTLDTTVHDY LKIDTIVSIL RDRFEDVFRY DAEGSPRLWK TEEEIDGAFR VAKEHALEVF
610 620 630 640 650 660
EVLSLAVTSD NVEIIPDVPM AEEESGEDNE IYRDNEGVFH SRRFAHILTE LQKENVLDQF
670 680 690 700 710 720
RRQINITVLD SKRSIITTRT HIPPWIYVLL AVLGWNEFVA VIRNPLFVTL TLILGATFFV
730 740 750 760 770
IHKFGLWGPV VNVVQSAVGE TRTAIKDKLR QFVVEDHEVK ESFEMKDFSK NEQKEK