Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

Autoinhibited structure

Activated structure

1 structures for Q0JLS6

Entry ID Method Resolution Chain Position Source
AF-Q0JLS6-F1 Predicted AlphaFoldDB

No variants for Q0JLS6

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q0JLS6

No associated diseases with Q0JLS6

2 regional properties for Q0JLS6

Type Name Position InterPro Accession
domain GB1/RHD3-type guanine nucleotide-binding (G) domain 34 - 249 IPR030386
domain Sey1/RHD3-like, three-helix bundle domain 320 - 755 IPR046758

Functions

Description
EC Number
Subcellular Localization
  • Endoplasmic reticulum membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

2 GO annotations of molecular function

Name Definition
GTP binding Binding to GTP, guanosine triphosphate.
GTPase activity Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate.

1 GO annotations of biological process

Name Definition
endoplasmic reticulum membrane fusion The joining of 2 or more lipid bilayer membranes that surround the endoplasmic reticulum.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q99287 SEY1 Protein SEY1 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
Q9SSN0 At1g72960 Protein ROOT HAIR DEFECTIVE 3 homolog 1 Arabidopsis thaliana (Mouse-ear cress) PR
P93042 NAT4 Protein ROOT HAIR DEFECTIVE 3 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MDACFSTQLI DGDGVFNVSG LENFMKEVKM GECGLSYAVV SIMGPQSSGK STLLNHLFRT
70 80 90 100 110 120
NFREMDAFKG RSQTTKGIWM AKAHNIEPCT LVMDLEGTDG RERGEDDTAF EKQSALFALA
130 140 150 160 170 180
VSDIVLINMW CHDIGREQAA NKPLLKTVFQ VMMRLFSPRK TTLLFVIRDK SKTPLENLEP
190 200 210 220 230 240
ILREDIQKIW DGVPKPHAHK ETPLSEFFNV EVVALSSYEE KEELFKEQVA SLRDRFQQSI
250 260 270 280 290 300
APGGLAGDRR GVVPASGFSF SSQQFWKVIK ENKDLDLPAH KVMVATVRCE EIGNEKIASF
310 320 330 340 350 360
TADEEWQQFE EAVQHDYVPG FGKKISNLLD RCLSEYDMEA IYFDEGVRTS KRHQLESKLL
370 380 390 400 410 420
QLVNPAYQNI LDHLRTRTLE VFKESFDKSL EKEGFAVAAR DCTKVFLEKF DKGSEDAAIQ
430 440 450 460 470 480
QVKWDPSKIK DKLKRDIEAH VASVRAKKLS ELCSKYEGQL TKALAEPVEA LLDSASEETW
490 500 510 520 530 540
PAIRKLLQRE TKSAVSGFES AMASFELDEV TQKELLSKLE SHGKSVVESK AKEEAARVLI
550 560 570 580 590 600
RMKDRFSTLF SRDADSMPRV WTGKEDIKAI TKTARSASMK LLSTMAAIRL DEDGDNIENT
610 620 630 640 650 660
LSLALVDTAR PGTTDRSIQS FDPLASSSWE RVPEEKTLIT PVQCKSLWRQ FKAETEYTVT
670 680 690 700 710 720
QAIAAQEANK RNNNWLPPPW ALAAMAILGF NEFMTLLKNP LYLGVIFVVF LVGKAMWVQL
730 740 750 760 770 780
DIAKEFQNGF LPAVLSLSTK FVPTIMNILK RLADEGQRPA APERQREMEL QPKSTRNGSH
790 800
SNVTSAGSSS ITSSESGPEY SSPIAH