AiPD: Autoinhibited Protein Database

Gene name	NAT4 (At1g49960, F2J10.14, F2J10.15)
Protein name	Protein ROOT HAIR DEFECTIVE 3
Names	Protein FRAGILE FIBER 4, Protein SEY1 homolog 1
Species	Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway	ath:AT3G13870
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

728-802 (Predicted disordered autoinhibitory region) PR

728-802 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-P93042-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
tmp_3_4570477_G_C	25	I>M	No	1000Genomes
ENSVATH05825577	27	E>A	No	1000Genomes
ENSVATH00321982	84	A>G	No	1000Genomes
tmp_3_4568842_C_T	243	G>S	No	1000Genomes
tmp_3_4568581_T_G	301	I>L	No	1000Genomes
ENSVATH05825532	331	A>S	No	1000Genomes
ENSVATH05825530	335	E>K	No	1000Genomes
tmp_3_4568246_G_A	338	T>I	No	1000Genomes
ENSVATH10662636	352	R>W	No	1000Genomes
ENSVATH13913889	379	L>F	No	1000Genomes
tmp_3_4567953_C_T	389	A>T	No	1000Genomes
tmp_3_4567935_C_G	395	G>R	No	1000Genomes
tmp_3_4567750_C_A	421	E>*	No	1000Genomes
tmp_3_4567693_C_T	440	A>T	No	1000Genomes
ENSVATH05825516	448	A>E	No	1000Genomes
ENSVATH05825509	502	A>V	No	1000Genomes
ENSVATH00321965	512	T>S	No	1000Genomes
ENSVATH10662597	517	L>V	No	1000Genomes
ENSVATH10662596	594	E>D	No	1000Genomes
tmp_3_4566878_C_A	611	G>C	No	1000Genomes
ENSVATH00321958	632	K>Q	No	1000Genomes
ENSVATH13913887	653	K>Q	No	1000Genomes
ENSVATH10662552	688	V>I	No	1000Genomes
ENSVATH00321951	731	V>A	No	1000Genomes
tmp_3_4565934_A_G	746	V>A	No	1000Genomes
tmp_3_4565910_G_A	754	A>V	No	1000Genomes
tmp_3_4565905_C_T	756	E>K	No	1000Genomes
ENSVATH13913883	758	Q>L	No	1000Genomes
tmp_3_4565788_T_C	795	N>D	No	1000Genomes
ENSVATH05825474	800	T>A	No	1000Genomes

Type	Name	Position	InterPro Accession
domain	GB1/RHD3-type guanine nucleotide-binding (G) domain	34 - 249	IPR030386
domain	Sey1/RHD3-like, three-helix bundle domain	320 - 756	IPR046758

		Description
EC Number
Subcellular Localization	Endoplasmic reticulum membrane ; Multi-pass membrane protein Golgi apparatus membrane
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
endoplasmic reticulum	The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
endoplasmic reticulum membrane	The lipid bilayer surrounding the endoplasmic reticulum.
Golgi membrane	The lipid bilayer surrounding any of the compartments of the Golgi apparatus.
integral component of membrane	The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plant-type vacuole	A closed structure that is completely surrounded by a unit membrane, contains liquid, and retains the same shape regardless of cell cycle phase. An example of this structure is found in Arabidopsis thaliana.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Name	Definition
GTP binding	Binding to GTP, guanosine triphosphate.
GTPase activity	Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate.

Name	Definition
actin cytoskeleton organization	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.
cell tip growth	Growth that occurs specifically at the tip of a cell.
endoplasmic reticulum membrane fusion	The joining of 2 or more lipid bilayer membranes that surround the endoplasmic reticulum.
endoplasmic reticulum to Golgi vesicle-mediated transport	The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi.
plant-type cell wall biogenesis	A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellulose and pectin-containing cell wall. An example of this is found in Arabidopsis thaliana.
root epidermal cell differentiation	The process in which a relatively unspecialized cell in the root epidermis acquires the specialized features of a trichoblast or atrichoblast.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q99287	SEY1	Protein SEY1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	PR
Q0JLS6	RHD3	Protein ROOT HAIR DEFECTIVE 3	Oryza sativa subsp japonica (Rice)	PR
Q9SSN0	At1g72960	Protein ROOT HAIR DEFECTIVE 3 homolog 1	Arabidopsis thaliana (Mouse-ear cress)	PR