AiPD: Autoinhibited Protein Database

Q96FK6

Gene name	WDR89 (C14orf150, MSTP050)
Protein name	WD repeat-containing protein 89
Names
Species	Homo sapiens (Human)
KEGG Pathway	hsa:112840
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

126-198 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

126-198 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for Q96FK6

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q96FK6-F1	Predicted				AlphaFoldDB

294 variants for Q96FK6

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA390114158 rs1318497582	4	I>F		No	ClinGen gnomAD
rs200143998 CA262476395	4	I>M		No	ClinGen 1000Genomes TOPMed
rs750241514 CA7218703	4	I>T		No	ClinGen ExAC gnomAD
CA390114159 rs1318497582	4	I>V		No	ClinGen gnomAD
CA7218702 rs764994750	5	E>G		No	ClinGen ExAC gnomAD
CA390114146 rs1378370767	6	E>*		No	ClinGen gnomAD
CA7218700 rs753811409	9	A>T		No	ClinGen ExAC TOPMed gnomAD
rs764140916 CA7218699	13	I>V		No	ClinGen ExAC TOPMed
rs1450813879 CA390114092	14	V>F		No	ClinGen gnomAD
rs760824874 CA7218698	16	C>Y		No	ClinGen ExAC gnomAD
rs1247642766 CA390114042	21	K>R		No	ClinGen gnomAD
CA7218696 rs767886112	23	P>L		No	ClinGen ExAC TOPMed gnomAD
CA390114029 rs1187840836	23	P>S		No	ClinGen TOPMed
rs1473513160 CA390114025	24	T>P		No	ClinGen TOPMed
CA7218694 CA7218695 rs774900502	25	Y>*		No	ClinGen ExAC TOPMed
rs775556998 CA7218693	25	Y>*		No	ClinGen ExAC TOPMed
CA390114005 rs1291347600	27	L>F		No	ClinGen gnomAD
CA390114007 rs1291347600	27	L>V		No	ClinGen gnomAD
CA7218692 rs771389100	29	I>R		No	ClinGen ExAC gnomAD
CA390113979 rs1158024560	31	T>A		No	ClinGen gnomAD
CA7218690 rs749824511 COSM553514	36	Q>*	lung [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA390113949 rs749824511	36	Q>K		No	ClinGen ExAC TOPMed gnomAD
rs935362687 CA262476393	37	A>T		No	ClinGen TOPMed gnomAD
CA7218687 rs746532791	38	G>V		No	ClinGen ExAC gnomAD
rs924037812 CA262476392	40	E>K		No	ClinGen Ensembl
rs758096970 CA7218685	41	N>K		No	ClinGen ExAC gnomAD
CA262476391 rs369057434	42	L>V		No	ClinGen gnomAD
CA262476389 rs946840690	47	C>Y		No	ClinGen Ensembl
TCGA novel	50	G>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs778748751 CA7218683	51	S>P		No	ClinGen ExAC TOPMed gnomAD
rs145676848 CA7218682	52	I>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs753521763 CA7218681	53	R>T		No	ClinGen ExAC gnomAD
rs368471602 CA7218679	56	D>G		No	ClinGen ESP ExAC TOPMed gnomAD
rs764100265 CA7218680	56	D>N		No	ClinGen ExAC gnomAD
rs901666396 CA262476386	57	K>R		No	ClinGen TOPMed gnomAD
rs11559174 CA262476385	58	E>G		No	ClinGen Ensembl
rs759875833 CA7218676	62	V>E		No	ClinGen ExAC TOPMed gnomAD
CA390113778 rs767678927	62	V>I		No	ClinGen ExAC gnomAD
rs767678927 CA7218677	62	V>L		No	ClinGen ExAC gnomAD
rs200681506 CA7218673	64	R>*		No	ClinGen ExAC TOPMed gnomAD
CA262476382 rs990207864	64	R>Q		No	ClinGen TOPMed gnomAD
rs773382192 CA7218672	67	S>N		No	ClinGen ExAC gnomAD
rs1170062591 CA390113737	68	G>V		No	ClinGen TOPMed
rs74383752 CA262476381	70	P>S		No	ClinGen TOPMed gnomAD
rs1404269796 CA390113714	72	L>H		No	ClinGen TOPMed
CA7218669 rs775021483	74	N>D		No	ClinGen ExAC gnomAD
rs1466124751 CA390113702	74	N>S		No	ClinGen gnomAD
TCGA novel	75	G>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs75569502 CA262476379	77	R>K		No	ClinGen TOPMed gnomAD
CA262476378 rs962037015	78	F>C		No	ClinGen Ensembl
CA390113638 rs1468744898	79	A>E		No	ClinGen TOPMed gnomAD
rs1468744898 CA390113636	79	A>V		No	ClinGen TOPMed gnomAD
rs745579304 CA7218667	80	N>D		No	ClinGen ExAC gnomAD
rs1433225460 CA390113618	81	S>P		No	ClinGen TOPMed
rs778552613 CA7218666	82	C>R		No	ClinGen ExAC gnomAD
rs1473655000 CA390113586	83	D>G		No	ClinGen gnomAD
TCGA novel	83	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA7218664 rs756794878	84	S>G		No	ClinGen ExAC gnomAD
CA7218662 rs140159540	86	Y>F		No	ClinGen 1000Genomes ExAC gnomAD
CA390113534 rs940317302	87	S>A		No	ClinGen TOPMed gnomAD
CA262476375 rs940317302	87	S>P		No	ClinGen TOPMed gnomAD
CA262476374 rs918064794	88	A>G		No	ClinGen TOPMed gnomAD
rs777385564 CA7218661	88	A>S		No	ClinGen ExAC gnomAD
CA614738533 rs1322810511	89	C>*		No	ClinGen gnomAD
rs992348595 CA262476373	89	C>Y		No	ClinGen TOPMed gnomAD
rs1595013008 CA390113454	93	T>I		No	ClinGen Ensembl
rs1006352832 CA262476371	95	K>E		No	ClinGen gnomAD
rs752646441 CA7218659	96	C>*		No	ClinGen ExAC TOPMed gnomAD
CA262476369 rs968117645	98	D>E		No	ClinGen TOPMed gnomAD
rs944955056 CA262476368	100	R>*		No	ClinGen TOPMed gnomAD
rs769328267 CA7218658	100	R>Q		No	ClinGen ExAC gnomAD
CA7218657 rs755092203	101	V>I		No	ClinGen ExAC TOPMed gnomAD
CA390113337 rs1262476077	103	R>G		No	ClinGen TOPMed gnomAD
rs1009886361 CA262476367	103	R>S		No	ClinGen TOPMed gnomAD
TCGA novel	104	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs751630935 CA7218656	105	K>E		No	ClinGen ExAC gnomAD
TCGA novel	105	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs201238690 CA7218654	112	G>D		No	ClinGen ExAC TOPMed gnomAD
rs201238690 CA262476365	112	G>V		No	ClinGen ExAC TOPMed gnomAD
rs1389667413 CA390113185	113	Y>C		No	ClinGen TOPMed
rs1386421939 CA390113173	114	P>S		No	ClinGen TOPMed
CA262476362 rs867110082	115	S>A		No	ClinGen Ensembl
CA7218650 rs762450286	116	N>D		No	ClinGen ExAC TOPMed gnomAD
CA7218651 rs762450286	116	N>Y		No	ClinGen ExAC TOPMed gnomAD
rs1459180736 CA390113136	117	I>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA262476360 rs1049802936	120	S>N		No	ClinGen TOPMed gnomAD
CA262476361 rs889833191	120	S>R		No	ClinGen TOPMed gnomAD
CA390113077 rs1416039138	121	F>C		No	ClinGen gnomAD
rs759055176 CA7218647	124	N>S		No	ClinGen ExAC gnomAD
CA7218646 rs773812709	125	C>Y		No	ClinGen ExAC gnomAD
CA390113021 rs1566788038	126	N>T		No	ClinGen Ensembl
rs1210317344 CA390113013	127	D>G		No	ClinGen gnomAD
rs1424360120 CA390113015	127	D>H		No	ClinGen Ensembl
rs1023719305 CA262476358	128	H>R		No	ClinGen gnomAD
TCGA novel	130	I>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA390112978 rs770642898	132	A>P		No	ClinGen ExAC TOPMed gnomAD
CA7218643 rs770642898 COSM553515	132	A>S	lung [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs1309876605 CA390112965	134	T>I		No	ClinGen gnomAD
rs1244615193 CA390112960	135	E>*		No	ClinGen gnomAD
CA390112958 rs1268201266	135	E>G		No	ClinGen TOPMed
CA7218641 rs148702795	136	K>N		No	ClinGen ESP ExAC TOPMed gnomAD
CA7218639 rs748151073	139	D>G		No	ClinGen ExAC gnomAD
rs1383237011 CA390112933	139	D>N		No	ClinGen gnomAD
CA390112926 rs1181133678	140	D>Y		No	ClinGen TOPMed
CA7218637 COSM956881 rs568191399	141	A>V	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC NCI-TCGA gnomAD
rs182117567 CA7218636	144	V>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
TCGA novel	144	V>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs145041046 CA7218635	145	F>L		No	ClinGen ESP ExAC gnomAD
CA390112880 rs1190406827	146	W>*		No	ClinGen gnomAD
rs1390908091 CA390112882	146	W>L		No	ClinGen gnomAD
rs1465350616 CA390112886	146	W>R		No	ClinGen gnomAD
rs149880774 CA7218633	149	R>K		No	ClinGen ESP ExAC TOPMed gnomAD
rs765693183 CA7218632	150	M>L		No	ClinGen ExAC gnomAD
rs1289164369 CA390112855	150	M>T		No	ClinGen gnomAD
TCGA novel	152	S>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs764619523 CA7218629	156	S>C		No	ClinGen ExAC gnomAD
CA7218630 rs754138741	156	S>P		No	ClinGen ExAC TOPMed gnomAD
rs764619523 CA390112811	156	S>Y		No	ClinGen ExAC gnomAD
rs528213124 CA262476355	160	D>V		No	ClinGen 1000Genomes
CA7218628 rs761125927	161	S>L		No	ClinGen ExAC
CA7218626 rs770313000	162	L>F		No	ClinGen ExAC gnomAD
CA262476354 rs749358111	163	G>D		No	ClinGen ExAC TOPMed gnomAD
rs749358111 CA7218625	163	G>V		No	ClinGen ExAC TOPMed gnomAD
CA390112763 rs1369938997	164	A>V		No	ClinGen gnomAD
rs769427475 CA7218623	165	Y>F		No	ClinGen ExAC gnomAD
rs1307738382 CA390112762	165	Y>N		No	ClinGen TOPMed
CA7218622 rs747960741	166	S>*		No	ClinGen ExAC gnomAD
rs781092628 CA7218621	168	T>A		No	ClinGen ExAC gnomAD
rs1595012563 CA390112734	169	H>R		No	ClinGen Ensembl
CA7218620 rs768735877	170	S>I		No	ClinGen ExAC TOPMed gnomAD
CA7218619 rs746920533	172	D>V		No	ClinGen ExAC gnomAD
CA390112696 rs1288479538	174	T>I		No	ClinGen TOPMed
CA390112697 rs1288479538	174	T>S		No	ClinGen TOPMed
rs780247394 CA7218618	177	R>C		No	ClinGen ExAC TOPMed gnomAD
CA7218617 rs758395247	177	R>H		No	ClinGen ExAC gnomAD
rs1434716533 CA390112663	179	H>Q		No	ClinGen TOPMed gnomAD
rs780342333 CA262476352	180	P>A		No	ClinGen Ensembl
TCGA novel	181	S>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs376554740 CA7218616	183	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA390112631 rs1204184387	184	N>S		No	ClinGen TOPMed
rs572281010 CA7218615	185	M>L		No	ClinGen ExAC TOPMed gnomAD
rs1483213368 CA390112624	185	M>R		No	ClinGen gnomAD
rs572281010 CA7218614	185	M>V		No	ClinGen ExAC TOPMed gnomAD
rs1276152718 CA390112619	186	V>L		No	ClinGen gnomAD
CA390112607 rs1337954010	188	S>P	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA7218612 rs764423387	189	G>D		No	ClinGen ExAC gnomAD
rs753135459 CA7218610	190	S>L		No	ClinGen ExAC gnomAD
CA7218611 rs370460278	190	S>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs1404562749 CA390112588	191	S>F		No	ClinGen gnomAD
rs558790163 CA7218609	194	L>P		No	ClinGen ExAC TOPMed gnomAD
rs762381683 CA7218608	196	N>S		No	ClinGen ExAC TOPMed gnomAD
rs772710618 CA7218607	199	D>N		No	ClinGen ExAC TOPMed gnomAD
CA7218605 rs1555373501	200	I>T		No	ClinGen Ensembl
CA390112528 rs1566787747	201	N>D		No	ClinGen Ensembl
rs1566787741 CA390112523	201	N>K		No	ClinGen Ensembl
rs1412265660 CA390112525	201	N>S		No	ClinGen TOPMed
CA390112517 rs1555373499	202	I>T		No	ClinGen Ensembl
CA390112506 rs1309201247	204	N>D		No	ClinGen TOPMed
rs765012400 CA7218604	204	N>K		No	ClinGen ExAC gnomAD
rs761507652 CA7218603	205	E>K		No	ClinGen ExAC
rs1426929235 CA390112492	206	E>K		No	ClinGen gnomAD
TCGA novel	208	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs776617300 CA7218602	210	V>D		No	ClinGen ExAC gnomAD
rs1393811235 CA390112453	212	T>A		No	ClinGen TOPMed
rs768567956 CA7218601	215	S>P		No	ClinGen ExAC gnomAD
CA262476349 rs147383587	216	I>S		No	ClinGen ESP
rs138997693 CA7218600	216	I>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs374715164 CA7218599	220	S>N		No	ClinGen ESP ExAC TOPMed gnomAD
CA7218598 rs771981347	222	I>V		No	ClinGen ExAC gnomAD
CA390112370 rs1261584321	224	W>C		No	ClinGen TOPMed gnomAD
rs1595012320 CA390112366	225	S>A		No	ClinGen Ensembl
CA7218597 rs745968925	225	S>C		No	ClinGen ExAC gnomAD
rs1373979816 CA390112358	226	G>V		No	ClinGen gnomAD
rs1595012310 CA390112356	227	K>E		No	ClinGen Ensembl
rs1343999819 CA390112346	228	G>D		No	ClinGen TOPMed
CA390112334 rs1205559013	229	Y>*		No	ClinGen TOPMed
CA7218595 rs551757796	232	I>F		No	ClinGen 1000Genomes ExAC gnomAD
CA7218593 rs531940599	232	I>M		No	ClinGen 1000Genomes ExAC gnomAD
CA7218592 rs756454182	235	M>L		No	ClinGen ExAC gnomAD
CA390112296 rs756454182	235	M>V		No	ClinGen ExAC gnomAD
rs753044102 CA262476348	236	T>A		No	ClinGen ExAC TOPMed gnomAD
rs767911526 CA7218590	236	T>I		No	ClinGen ExAC TOPMed gnomAD
CA390112287 rs767911526	236	T>K		No	ClinGen ExAC TOPMed gnomAD
rs753044102 CA7218591	236	T>S		No	ClinGen ExAC TOPMed gnomAD
CA7218589 rs750610048	237	H>D		No	ClinGen ExAC
CA390112274 rs1258332498	238	D>G		No	ClinGen TOPMed
CA390112234 rs984476162	243	W>*		No	ClinGen gnomAD
rs984476162 CA262476346	243	W>C		No	ClinGen gnomAD
CA7218587 rs764816447	248	H>R		No	ClinGen ExAC TOPMed gnomAD
rs1156424807 CA390112199	248	H>Y		No	ClinGen gnomAD
CA390112188 rs1189023699	250	D>H		No	ClinGen gnomAD
rs1241855476 CA390112154	254	P>L		No	ClinGen gnomAD
rs776410645 CA7218585	255	V>L		No	ClinGen ExAC TOPMed gnomAD
CA7218583 rs760393455	257	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs775316974 CA7218582	257	R>H		No	ClinGen ExAC TOPMed gnomAD
rs775316974 CA390112139	257	R>L		No	ClinGen ExAC TOPMed gnomAD
rs202102295 CA262476344	263	V>I		No	ClinGen gnomAD
rs1380429407 CA390112088	265	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs770997597 CA7218578	268	N>D		No	ClinGen ExAC gnomAD
rs140383002 CA7218577	269	M>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs147523002 CA262476343	275	D>N		No	ClinGen ESP TOPMed
CA7218576 rs777981551	276	Y>C		No	ClinGen ExAC TOPMed gnomAD
rs200689505 CA262476342	276	Y>N		No	ClinGen gnomAD
TCGA novel	278	I>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA390111993 rs1566787566	278	I>T		No	ClinGen Ensembl
rs143165130 CA7218575	279	G>D		No	ClinGen ESP ExAC gnomAD
CA390111989 rs1277647565	279	G>S		No	ClinGen TOPMed
CA7218574 rs748490107	280	G>D		No	ClinGen ExAC gnomAD
CA7218573 rs781569591	281	L>V		No	ClinGen ExAC TOPMed gnomAD
rs752074989 CA7218571	282	Y>H		No	ClinGen ExAC
TCGA novel	283	H>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1212119686 CA390111940	286	T>R		No	ClinGen TOPMed
rs778623681 CA7218570	287	D>E		No	ClinGen ExAC gnomAD
CA390111930 rs1384109763	288	T>A		No	ClinGen gnomAD
rs1450705425 CA390111922	289	L>S		No	ClinGen gnomAD
rs1244193578 CA390111915	290	H>P		No	ClinGen gnomAD
CA7218568 rs753332841	291	V>I		No	ClinGen ExAC gnomAD
rs763872055 CA7218567	292	I>T		No	ClinGen ExAC gnomAD
rs1566787525 CA390111899	293	G>R		No	ClinGen Ensembl
CA390111889 rs1290890640	294	G>A		No	ClinGen TOPMed gnomAD
CA390111886 rs1224765834	295	T>A		No	ClinGen gnomAD
CA390111873 rs1357333903	297	K>Q		No	ClinGen gnomAD
rs148379805 CA7218565	298	G>R		No	ClinGen ESP TOPMed gnomAD
TCGA novel	299	R>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs541626796 CA7218561	307	M>V		No	ClinGen 1000Genomes ExAC gnomAD
rs1429793227 CA390111780	309	G>E		No	ClinGen gnomAD
CA7218560 rs143334972	312	H>P		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA7218559 rs774253682	312	H>Q		No	ClinGen ExAC gnomAD
CA390111761 rs1422410741	313	V>L		No	ClinGen gnomAD
CA390111748 rs1358038416	315	S>G		No	ClinGen gnomAD
COSM553518 rs1263101419 CA390111743	315	S>R	lung [Cosmic]	No	ClinGen cosmic curated gnomAD
rs950244789 CA262476341	318	G>R		No	ClinGen TOPMed
CA7218557 rs367918227	319	G>E		No	ClinGen ESP ExAC TOPMed gnomAD
CA390111722 rs1422291845	319	G>R		No	ClinGen gnomAD
CA390111705 rs141157376	321	A>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA7218556 rs141157376	321	A>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1595011915 CA390111699	322	A>V		No	ClinGen Ensembl
rs1201830923 CA390111698	323	T>A		No	ClinGen gnomAD
CA262476339 rs889868982	323	T>I		No	ClinGen TOPMed
CA7218555 rs769929699 COSM1740090	325	R>C	haematopoietic_and_lymphoid_tissue [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA7218554 rs188415224	325	R>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA390111678 rs1390468504	326	S>F		No	ClinGen TOPMed
TCGA novel	327	F>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1595011887 CA390111665	328	C>Y		No	ClinGen Ensembl
TCGA novel	330	N>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA7218553 rs200346449	331	V>M		No	ClinGen 1000Genomes ExAC gnomAD
CA390111636 rs1430993797	332	Q>R		No	ClinGen TOPMed
CA7218550 rs780712409	337	L>F		No	ClinGen ExAC TOPMed gnomAD
rs758936068 CA7218549	339	G>R		No	ClinGen ExAC TOPMed
rs1444279086	340	G>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA390111585 rs1345421570	340	G>R		No	ClinGen gnomAD
CA7218547 rs777402670	343	A>E		No	ClinGen ExAC TOPMed gnomAD
CA390111455 rs1566787402	350	P>S		No	ClinGen Ensembl
CA390111424 rs1356749798	353	I>L		No	ClinGen TOPMed gnomAD
TCGA novel	353	I>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA390111421 rs1356749798	353	I>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs571324018 CA7218543	354	E>G		No	ClinGen ExAC TOPMed gnomAD
CA7218542 rs759385278	355	K>E		No	ClinGen ExAC gnomAD
TCGA novel	355	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA390111360 rs1179036021	358	T>A		No	ClinGen gnomAD
rs201297563 CA262476336	358	T>R		No	ClinGen 1000Genomes
CA262476335 rs202032576	359	K>R		No	ClinGen 1000Genomes
CA390111341 rs1566787378	360	K>E		No	ClinGen Ensembl
rs1566787367	360	K>R	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs1566787366 COSM168068 TCGA novel CA390111317	361	E>D	Variant assessed as Somatic; impact. large_intestine [NCI-TCGA, Cosmic]	No	NCI-TCGA ClinGen cosmic curated Ensembl
CA390111329 rs1388874515	361	E>K		No	ClinGen gnomAD
rs1479546173 CA390111312	362	S>C		No	ClinGen gnomAD
rs1216745206 CA390111308	362	S>N		No	ClinGen TOPMed
rs369959005 CA262476333	363	M>K		No	ClinGen ESP ExAC gnomAD
CA7218539 rs369959005	363	M>T		No	ClinGen ESP ExAC gnomAD
CA390111263 rs1454408190	365	I>V		No	ClinGen TOPMed gnomAD
CA390111247 rs1193237153	366	A>S		No	ClinGen TOPMed
rs762826018 CA7218538	366	A>V		No	ClinGen ExAC gnomAD
CA7218536 rs769884640	368	S>C		No	ClinGen ExAC TOPMed gnomAD
CA7218537 rs769884640	368	S>F		No	ClinGen ExAC TOPMed gnomAD
rs138166073 CA7218535	369	V>M		No	ClinGen ESP ExAC TOPMed gnomAD
CA390111203 rs1439462814	370	H>L		No	ClinGen gnomAD
CA390111193 rs371589367	371	Q>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA262476332 rs545435704	372	R>*		No	ClinGen gnomAD
CA7218533 rs368654685	372	R>Q		No	ClinGen ESP ExAC TOPMed
CA390111184 rs1595011629	373	V>A		No	ClinGen Ensembl
rs775949617 CA7218531	374	R>*		No	ClinGen ExAC TOPMed gnomAD
rs576477902 CA7218530	374	R>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA390111161 rs1264870883	376	H>Q		No	ClinGen gnomAD
rs777219589 CA7218528	376	H>R		No	ClinGen ExAC gnomAD
CA7218529 rs746348481	376	H>Y		No	ClinGen ExAC gnomAD
rs1297161822 CA390111156	377	S>G		No	ClinGen TOPMed gnomAD
CA7218527 rs755640808	377	S>N		No	ClinGen ExAC gnomAD
rs140633404 CA7218526	378	N>S		No	ClinGen ESP ExAC
rs780897713 CA390111092	381	Y>*		No	ClinGen ExAC gnomAD
rs1339050283 CA390111068	383	R>K		No	ClinGen gnomAD
TCGA novel	383	R>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA390111056 rs1468598295	384	R>K		No	ClinGen gnomAD
rs1595011561 CA390110993	388	Q>W		No	ClinGen Ensembl

No associated diseases with Q96FK6

No regional properties for Q96FK6

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for Q96FK6

Functions

		Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

No GO annotations of cellular component

Name	Definition
No GO annotations for cellular component

No GO annotations of molecular function

Name	Definition
No GO annotations for molecular function

No GO annotations of biological process

Name	Definition
No GO annotations for biological process

3 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P53962	YNL035C	Uncharacterized WD repeat-containing protein YNL035C	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	PR
Q3ZBK1	WDR89	WD repeat-containing protein 89	Bos taurus (Bovine)	PR
Q9D0R9	Wdr89	WD repeat-containing protein 89	Mus musculus (Mouse)	PR

10	20	30	40	50	60
MEKIEEQFAN	LHIVKCSLGT	KEPTYLLGID	TSKTVQAGKE	NLVAVLCSNG	SIRIYDKERL
70	80	90	100	110	120
NVLREFSGYP	GLLNGVRFAN	SCDSVYSACT	DGTVKCWDAR	VAREKPVQLF	KGYPSNIFIS
130	140	150	160	170	180
FDINCNDHII	CAGTEKVDDD	ALLVFWDARM	NSQNLSTTKD	SLGAYSETHS	DDVTQVRFHP
190	200	210	220	230	240
SNPNMVVSGS	SDGLVNVFDI	NIDNEEDALV	TTCNSISSVS	CIGWSGKGYK	QIYCMTHDEG
250	260	270	280	290	300
FYWWDLNHLD	TDEPVTRLNI	QDVREVVNMK	EDALDYLIGG	LYHEKTDTLH	VIGGTNKGRI
310	320	330	340	350	360
HLMNCSMSGL	THVTSLQGGH	AATVRSFCWN	VQDDSLLTGG	EDAQLLLWKP	GAIEKTFTKK
370	380
ESMKIASSVH	QRVRVHSNDS	YKRRKKQ