AiPD: Autoinhibited Protein Database

Q96CG3

Gene name	TIFA
Protein name	TRAF-interacting protein with FHA domain-containing protein A
Names	Putative MAPK-activating protein PM14, Putative NF-kappa-B-activating protein 20, TRAF2-binding protein
Species	Homo sapiens (Human)
KEGG Pathway	hsa:92610
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

128-184 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

128-184 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

5 structures for Q96CG3

Entry ID	Method	Resolution	Chain	Position	Source
4YM4	X-ray	312 A			PDB
4ZGI	X-ray	270 A	A	10-149	PDB
5ZUJ	X-ray	260 A	I	170-184	PDB
6A33	X-ray	210 A	I	170-184	PDB
AF-Q96CG3-F1	Predicted				AlphaFoldDB

128 variants for Q96CG3

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs1304548289 CA357992102	2	T>N		No	ClinGen gnomAD
rs907123851 CA104406577	3	S>N		No	ClinGen Ensembl
rs767562614 CA3046213	4	F>S		No	ClinGen ExAC gnomAD
rs545028676 CA104406576	7	A>D		No	ClinGen Ensembl
rs759343955 CA3046211	11	E>D		No	ClinGen ExAC TOPMed gnomAD
CA357992030 rs1187221003	12	T>I		No	ClinGen gnomAD
CA3046209 rs766122633	14	T>I		No	ClinGen ExAC gnomAD
rs1201502442 CA357992010	16	L>F		No	ClinGen gnomAD
CA3046208 rs762733411	16	L>R		No	ClinGen ExAC gnomAD
rs1201502442 CA357992008	16	L>V		No	ClinGen gnomAD
COSM447241 CA3046207 rs772755702 CA104406575	17	Q>H	Variant assessed as Somatic; 0.0 impact. breast [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
VAR_051422 CA3046206 rs6834237	19	T>M		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs1243748377 CA357991967	22	H>R		No	ClinGen gnomAD
rs1578431182 CA357991969	22	H>Y		No	ClinGen Ensembl
rs775803812 CA3046203	24	G>C		No	ClinGen ExAC gnomAD
rs772627267 CA357991945	25	Q>H		No	ClinGen ExAC TOPMed gnomAD
CA3046201 rs746228776	28	C>G		No	ClinGen ExAC TOPMed gnomAD
rs1231493384 CA357991912	30	I>T		No	ClinGen TOPMed
CA104406574 COSM1471599 rs984353886	34	I>V	Variant assessed as Somatic; 0.0 impact. prostate [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
rs774739590 CA3046200	35	S>R		No	ClinGen ExAC gnomAD
TCGA novel	39	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA3046197 rs749425151	45	E>A		No	ClinGen ExAC gnomAD
rs778091662 CA3046196	47	V>M		No	ClinGen ExAC gnomAD
TCGA novel	49	F>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA357991782 rs1282512908	49	F>L		No	ClinGen TOPMed
rs200608467 CA3046195	51	R>*		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA3046194 rs748270021	51	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs147617925 CA3046193	52	N>D		No	ClinGen ESP ExAC TOPMed
rs1030595375 CA104406569	53	S>P		No	ClinGen TOPMed
CA357991734 rs1560620740	56	C>F		No	ClinGen Ensembl
CA357991735 rs1560620740	56	C>Y		No	ClinGen Ensembl
rs755030639 CA3046192	57	H>P		No	ClinGen ExAC gnomAD
CA3046191 rs751366814	58	Y>S		No	ClinGen ExAC gnomAD
CA357991716 rs1266986450	59	T>A		No	ClinGen gnomAD
CA357991712 rs1233680461	59	T>I		No	ClinGen gnomAD
rs758233841 CA3046189	60	F>C		No	ClinGen ExAC gnomAD
rs190573450 CA3046188	61	Q>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA357991696 rs1340571021	62	D>N		No	ClinGen gnomAD
rs1403237324 CA357991671	65	V>F		No	ClinGen gnomAD
rs1176013464 CA357991662	66	S>F		No	ClinGen TOPMed gnomAD
CA3046186 rs367861259	67	R>*		No	ClinGen ESP ExAC TOPMed gnomAD
CA357991658 rs1164133695	67	R>Q		No	ClinGen gnomAD
CA357991645 rs1425275876	69	Q>H		No	ClinGen gnomAD
rs1335147282 CA357991635	71	S>T		No	ClinGen TOPMed
rs1200937820 CA357991629	72	L>V		No	ClinGen gnomAD
TCGA novel	73	Q>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1476671629 CA357991600	76	K>R		No	ClinGen gnomAD
rs760087567 CA3046183	78	F>C		No	ClinGen ExAC gnomAD
CA357991576 rs1478463658	79	N>S		No	ClinGen gnomAD
rs377395836 CA3046181	83	L>H		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	83	L>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA357991534 rs1268346767	85	F>L		No	ClinGen gnomAD
rs1453475024 CA357991537	85	F>S		No	ClinGen gnomAD
rs749672723 CA3046180	90	M>L		No	ClinGen ExAC gnomAD
rs749672723 CA357991501	90	M>V		No	ClinGen ExAC gnomAD
CA357991491 rs1290287295	91	S>N		No	ClinGen TOPMed
TCGA novel	93	K>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA357991467 rs1317038287	94	T>S		No	ClinGen gnomAD
CA3046179 rs773253158	95	N>H		No	ClinGen ExAC TOPMed gnomAD
CA3046178 rs770115405	95	N>S		No	ClinGen ExAC TOPMed gnomAD
rs1347528219 CA357991455	96	L>P		No	ClinGen TOPMed
CA357991447 rs145658027	97	I>M		No	ClinGen ESP ExAC TOPMed gnomAD
rs746895882 CA3046173	98	V>M		No	ClinGen ExAC TOPMed gnomAD
CA357991404 rs1173349394	104	G>R		No	ClinGen gnomAD
rs758071418 CA3046171	106	L>Q		No	ClinGen ExAC gnomAD
CA3046169 rs764792124	107	N>K		No	ClinGen ExAC gnomAD
CA3046170 rs750289659	107	N>S		No	ClinGen ExAC gnomAD
rs753321052 CA3046167	109	M>R		No	ClinGen ExAC gnomAD
CA3046165 rs199883669	110	D>A		No	ClinGen ExAC
CA357991362 rs199883669	110	D>G		No	ClinGen ExAC
CA3046166 rs763542537	110	D>H		No	ClinGen ExAC gnomAD
CA357991353 rs1469074069	112	P>A		No	ClinGen Ensembl
CA104406567 rs1034397169	115	C>Y		No	ClinGen Ensembl
CA3046162 rs373194424	116	M>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA3046161 rs149765370	117	V>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1303575134 CA357991313	118	R>G		No	ClinGen gnomAD
rs762145910 CA357991298 CA3046159	120	G>R		No	ClinGen ExAC TOPMed gnomAD
rs1309950243 CA357991289	121	E>G		No	ClinGen TOPMed
TCGA novel	123	Q>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA357991275 rs1333707674	123	Q>K		No	ClinGen TOPMed gnomAD
rs1327484893 CA357991261	125	L>V		No	ClinGen TOPMed
CA357991251 rs1234496419	126	M>I		No	ClinGen TOPMed
rs1359051431 CA357991256	126	M>L		No	ClinGen gnomAD
rs1047003428 CA104406565	126	M>T		No	ClinGen TOPMed gnomAD
rs777016113 CA3046158	127	E>D		No	ClinGen ExAC gnomAD
CA104406564 rs994473821	128	K>E		No	ClinGen Ensembl
CA357991238 rs1425942008	128	K>R		No	ClinGen gnomAD
CA357991211 rs747090217	132	E>*		No	ClinGen ExAC gnomAD
CA3046156 rs747090217	132	E>K		No	ClinGen ExAC gnomAD
CA3046154 rs151053905	136	F>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA357991178 rs1470410169	136	F>L		No	ClinGen gnomAD
rs1236727820 CA357991162	138	E>D		No	ClinGen TOPMed gnomAD
rs1302572317	143	L>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA3046152 rs745618298	143	L>F		No	ClinGen ExAC gnomAD
CA3046151 rs144304339	144	S>P		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA3046150 rs757021762	145	P>T		No	ClinGen ExAC gnomAD
CA357991110 rs1578430899	146	R>S		No	ClinGen Ensembl
rs777403705 CA3046148	147	S>*		No	ClinGen ExAC TOPMed gnomAD
rs146364351 CA3046146	148	L>P		No	ClinGen ESP ExAC TOPMed gnomAD
rs139652915 CA3046147	148	L>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs369015007 CA3046145	149	L>F		No	ClinGen ESP ExAC TOPMed gnomAD
rs759247567 CA104406562	150	Q>K		No	ClinGen TOPMed gnomAD
CA357991091 rs1390988700	150	Q>R		No	ClinGen TOPMed
rs1461589229 CA357991083	151	E>G		No	ClinGen TOPMed
CA357991071 rs763557853	153	N>D		No	ClinGen ExAC TOPMed gnomAD
CA3046143 rs763557853	153	N>H		No	ClinGen ExAC TOPMed gnomAD
rs763557853 CA3046144	153	N>Y		No	ClinGen ExAC TOPMed gnomAD
rs1362645546 CA357991046	156	P>L		No	ClinGen gnomAD
CA3046141 rs750733961	156	P>S		No	ClinGen ExAC gnomAD
CA3046137 rs377097517	161	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA357991013 rs377097517	161	P>Q		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	163	Y>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA357990993 rs1258154430	164	G>D		No	ClinGen gnomAD
rs977738387 CA104406561	165	T>A		No	ClinGen Ensembl
CA357990978 CA357990979 rs701759	166	Y>*		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA104406560 rs386678484	167	S>L		No	ClinGen Ensembl
rs199732553 CA3046133	167	S>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs372161211 CA3046132	168	L>F		No	ClinGen ESP ExAC TOPMed gnomAD
rs1288079952 CA357990963	169	C>S		No	ClinGen gnomAD
rs770689605 CA3046131	170	S>T		No	ClinGen ExAC gnomAD
COSM143610 rs1356602224 CA357990949	171	S>F	skin [Cosmic]	No	ClinGen cosmic curated gnomAD
rs770536962 CA3046129	173	S>G		No	ClinGen ExAC TOPMed gnomAD
rs144405805 CA3046128	176	P>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs188242608 CA104406557	178	E>*		No	ClinGen 1000Genomes
rs1002946108 CA104406556	179	M>V		No	ClinGen Ensembl
CA3046125 rs780805703	180	D>G		No	ClinGen ExAC gnomAD
TCGA novel	181	E>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1462839352 CA357990872	182	N>S		No	ClinGen gnomAD

No associated diseases with Q96CG3

3 regional properties for Q96CG3

Type	Name	Position	InterPro Accession
domain	Transmembrane protein TMEM132, N-terminal	50 - 167	IPR031435
domain	Transmembrane protein TMEM132, C-terminal	821 - 902	IPR031436
domain	Transmembrane protein family 132, middle domain	407 - 749	IPR031437

Functions

		Description
EC Number
Subcellular Localization	Cytoplasm	Colocalizes with lysosomal marker LAMP2 following homooligomerization and subsequent activation
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

2 GO annotations of cellular component

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

No GO annotations of molecular function

Name	Definition
No GO annotations for molecular function

5 GO annotations of biological process

Name	Definition
cytoplasmic pattern recognition receptor signaling pathway	The series of molecular signals initiated by a ligand binding to a cytoplasmic pattern recognition receptor (PRR). PRRs bind pathogen-associated molecular pattern (PAMPs), structures conserved among microbial species.
I-kappaB kinase/NF-kappaB signaling	The process in which a signal is passed on to downstream components within the cell through the I-kappaB-kinase (IKK)-dependent activation of NF-kappaB. The cascade begins with activation of a trimeric IKK complex (consisting of catalytic kinase subunits IKKalpha and/or IKKbeta, and the regulatory scaffold protein NEMO) and ends with the regulation of transcription of target genes by NF-kappaB. In a resting state, NF-kappaB dimers are bound to I-kappaB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription.
innate immune response	Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.
positive regulation of I-kappaB kinase/NF-kappaB signaling	Any process that activates or increases the frequency, rate or extent of I-kappaB kinase/NF-kappaB signaling.
protein homooligomerization	The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer.

3 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
A2VDM0	TIFA	TRAF-interacting protein with FHA domain-containing protein A	Bos taurus (Bovine)	PR
Q793I8	Tifa	TRAF-interacting protein with FHA domain-containing protein A	Mus musculus (Mouse)	PR
Q5XIB9	Tifa	TRAF-interacting protein with FHA domain-containing protein A	Rattus norvegicus (Rat)	PR

10	20	30	40	50	60
MTSFEDADTE	ETVTCLQMTV	YHPGQLQCGI	FQSISFNREK	LPSSEVVKFG	RNSNICHYTF
70	80	90	100	110	120
QDKQVSRVQF	SLQLFKKFNS	SVLSFEIKNM	SKKTNLIVDS	RELGYLNKMD	LPYRCMVRFG
130	140	150	160	170	180
EYQFLMEKED	GESLEFFETQ	FILSPRSLLQ	ENNWPPHRPI	PEYGTYSLCS	SQSSSPTEMD

ENES