Q793I8
Gene name |
Tifa |
Protein name |
TRAF-interacting protein with FHA domain-containing protein A |
Names |
TRAF2-binding protein |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:211550 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
4 structures for Q793I8
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 6L9U | X-ray | 260 A | A | 1-184 | PDB |
| 6L9V | X-ray | 305 A | A/B/C/D | 1-184 | PDB |
| 6L9W | X-ray | 290 A | A/B/C/D/E/F | 1-184 | PDB |
| AF-Q793I8-F1 | Predicted | AlphaFoldDB |
14 variants for Q793I8
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388667045 | 5 | E>D | No | EVA | |
| rs3393562819 | 13 | V>* | No | EVA | |
| rs3388663113 | 52 | N>Y | No | EVA | |
| rs3388651097 | 65 | V>M | No | EVA | |
| rs261057523 | 68 | I>V | No | EVA | |
| rs36755141 | 82 | V>I | No | EVA | |
| rs47600032 | 94 | T>I | No | EVA | |
| rs3388667075 | 136 | S>T | No | EVA | |
| rs3388666176 | 146 | R>G | No | EVA | |
| rs3388660931 | 153 | N>Y | No | EVA | |
| rs3388660955 | 154 | W>C | No | EVA | |
| rs3388663037 | 154 | W>S | No | EVA | |
| rs3388652207 | 173 | R>S | No | EVA | |
| rs3388662057 | 174 | S>G | No | EVA |
No associated diseases with Q793I8
1 regional properties for Q793I8
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Forkhead-associated (FHA) domain | 47 - 120 | IPR000253 |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| cytoplasmic pattern recognition receptor signaling pathway | The series of molecular signals initiated by a ligand binding to a cytoplasmic pattern recognition receptor (PRR). PRRs bind pathogen-associated molecular pattern (PAMPs), structures conserved among microbial species. |
| I-kappaB kinase/NF-kappaB signaling | The process in which a signal is passed on to downstream components within the cell through the I-kappaB-kinase (IKK)-dependent activation of NF-kappaB. The cascade begins with activation of a trimeric IKK complex (consisting of catalytic kinase subunits IKKalpha and/or IKKbeta, and the regulatory scaffold protein NEMO) and ends with the regulation of transcription of target genes by NF-kappaB. In a resting state, NF-kappaB dimers are bound to I-kappaB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription. |
| innate immune response | Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. |
| positive regulation of I-kappaB kinase/NF-kappaB signaling | Any process that activates or increases the frequency, rate or extent of I-kappaB kinase/NF-kappaB signaling. |
| protein homooligomerization | The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer. |
3 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| A2VDM0 | TIFA | TRAF-interacting protein with FHA domain-containing protein A | Bos taurus (Bovine) | PR |
| Q96CG3 | TIFA | TRAF-interacting protein with FHA domain-containing protein A | Homo sapiens (Human) | PR |
| Q5XIB9 | Tifa | TRAF-interacting protein with FHA domain-containing protein A | Rattus norvegicus (Rat) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSTFEDADTE | ETVTCLQMTI | YHPGQQSGIF | KSIRFCSKEK | FPSIEVVKFG | RNSNMCQYTF |
| 70 | 80 | 90 | 100 | 110 | 120 |
| QDKQVSRIQF | VLQPFKQFNS | SVLSFEIKNM | SKKTSLMVDN | QELGYLNKMD | LPYKCMLRFG |
| 130 | 140 | 150 | 160 | 170 | 180 |
| EYQFLLQKED | GESVESFETQ | FIMSSRPLLQ | ENNWPTQNPI | PEDGMYSSYF | THRSSPSEMD |
| ENEL |