Q5XIB9

PR
Gene name
Tifa
Protein name
TRAF-interacting protein with FHA domain-containing protein A
Names
Species
Rattus norvegicus (Rat)
KEGG Pathway
rno:310877
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

107-185 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5XIB9

Entry ID Method Resolution Chain Position Source
AF-Q5XIB9-F1 Predicted AlphaFoldDB

No variants for Q5XIB9

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5XIB9

No associated diseases with Q5XIB9

1 regional properties for Q5XIB9

Type Name Position InterPro Accession
domain Forkhead-associated (FHA) domain 48 - 121 IPR000253

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Colocalizes with lysosomal marker LAMP2 following homooligomerization and subsequent activation
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

5 GO annotations of biological process

Name Definition
cytoplasmic pattern recognition receptor signaling pathway The series of molecular signals initiated by a ligand binding to a cytoplasmic pattern recognition receptor (PRR). PRRs bind pathogen-associated molecular pattern (PAMPs), structures conserved among microbial species.
I-kappaB kinase/NF-kappaB signaling The process in which a signal is passed on to downstream components within the cell through the I-kappaB-kinase (IKK)-dependent activation of NF-kappaB. The cascade begins with activation of a trimeric IKK complex (consisting of catalytic kinase subunits IKKalpha and/or IKKbeta, and the regulatory scaffold protein NEMO) and ends with the regulation of transcription of target genes by NF-kappaB. In a resting state, NF-kappaB dimers are bound to I-kappaB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription.
innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.
positive regulation of I-kappaB kinase/NF-kappaB signaling Any process that activates or increases the frequency, rate or extent of I-kappaB kinase/NF-kappaB signaling.
protein homooligomerization The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
A2VDM0 TIFA TRAF-interacting protein with FHA domain-containing protein A Bos taurus (Bovine) PR
Q96CG3 TIFA TRAF-interacting protein with FHA domain-containing protein A Homo sapiens (Human) PR
Q793I8 Tifa TRAF-interacting protein with FHA domain-containing protein A Mus musculus (Mouse) PR
10 20 30 40 50 60
MSTFEDADTE ETVTCLQMTI YHPGQLQSGI FKSIRFCSKE KFPSIEVVKF GRNSNMCQYT
70 80 90 100 110 120
FQDKQVSRVQ FALQPFKQFN SSVLSFEIKN MSKKTSLMVD NQELGYLNKM DLPYKCMLRF
130 140 150 160 170 180
GEYQFLLQKE DGESVESFET QFILSPRPLL QENNWPTQSP IPEDGVYSSY FTHRSSPAEM
DENEL