AiPD: Autoinhibited Protein Database

Q96A26

Gene name	FAM162A (C3orf28, E2IG5, DC16, FWP001)
Protein name	Protein FAM162A
Names	E2-induced gene 5 protein, Growth and transformation-dependent protein, HGTD-P
Species	Homo sapiens (Human)
KEGG Pathway	hsa:26355
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

9-80 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

9-80 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for Q96A26

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q96A26-F1	Predicted				AlphaFoldDB

133 variants for Q96A26

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs755437516 CA2570287	2	G>E		No	ClinGen ExAC TOPMed gnomAD
rs1225542726 CA354160138	2	G>R		No	ClinGen gnomAD
TCGA novel	3	S>?	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA2570288 rs115407410	3	S>N		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs200828323 CA2570289	4	L>F		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1476366520 CA354160175	5	S>G		No	ClinGen TOPMed
CA82766953 rs868299833	6	G>C		No	ClinGen TOPMed
rs1275244643 CA354160193	6	G>D		No	ClinGen gnomAD
rs868299833 CA354160189	6	G>R		No	ClinGen TOPMed
rs1469226938 CA354160211	8	R>C		No	ClinGen gnomAD
rs781609459 CA2570290	8	R>H		No	ClinGen ExAC TOPMed gnomAD
rs140995238 CA2570292	10	A>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA354164231 rs1168239605	12	G>E		No	ClinGen gnomAD
CA82762760 rs1036051638	13	S>G		No	ClinGen TOPMed
rs1432727556 CA354164262	16	R>K		No	ClinGen gnomAD
rs749708701 CA354164264	16	R>S		No	ClinGen ExAC TOPMed gnomAD
rs201624968 CA2570316	17	L>F		No	ClinGen ExAC gnomAD
rs1348398366 CA354164273	18	C>R		No	ClinGen TOPMed
CA354164277 rs1560001658	18	C>Y		No	ClinGen Ensembl
rs778487652 CA2570317	19	E>K		No	ClinGen ExAC TOPMed gnomAD
rs373633927 CA2570318	20	R>G		No	ClinGen ESP ExAC TOPMed gnomAD
CA82762783 rs531678380	20	R>K		No	ClinGen Ensembl
rs1328372159 CA354164292	21	D>N		No	ClinGen TOPMed gnomAD
rs778571663 CA82762793	22	V>I		No	ClinGen TOPMed
CA354164328 rs1560001670	27	R>G		No	ClinGen Ensembl
CA354164336 rs1233353002	28	L>F		No	ClinGen gnomAD
rs1404836392 CA354164346	29	T>I		No	ClinGen TOPMed
rs11555937 CA82762816	30	R>G		No	ClinGen Ensembl
rs930471281 CA82762821	31	S>T		No	ClinGen Ensembl
TCGA novel	38	N>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA354164405 rs1162016480	38	N>Y		No	ClinGen TOPMed
CA2570324 rs776548425	39	G>R		No	ClinGen ExAC gnomAD
TCGA novel	39	G>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1281738853 CA354164429	41	C>F		No	ClinGen TOPMed gnomAD
rs1281738853 CA354164427	41	C>Y		No	ClinGen TOPMed gnomAD
CA2570325 rs759386513	42	T>R		No	ClinGen ExAC gnomAD
TCGA novel	43	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA2570326 rs527285562	44	P>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA354164462 rs1294651109	46	E>G		No	ClinGen gnomAD
CA2570327 rs752371117	47	S>N		No	ClinGen ExAC gnomAD
rs1177574416 CA354164475	48	P>S		No	ClinGen TOPMed
rs745565586 CA2570329	49	G>R		No	ClinGen ExAC TOPMed gnomAD
CA354164484 rs1009201381	50	A>P		No	ClinGen TOPMed
rs1009201381 CA82762871	50	A>T		No	ClinGen TOPMed
CA82762877 VAR_028849 rs17850692	50	A>V		No	ClinGen UniProt Ensembl dbSNP
rs199578714 CA2570331 COSM1238831 COSM1238830	53	R>C	oesophagus [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
CA354164514 rs1326915969	53	R>H		No	ClinGen gnomAD
CA2570346 CA354164539 rs775378118	55	Y>*		No	ClinGen ExAC gnomAD
rs747971677 CA2570345	55	Y>*		No	ClinGen ESP ExAC TOPMed gnomAD
rs947256688 CA82763612	55	Y>H		No	ClinGen TOPMed
CA354164583 rs1300454506	59	P>L		No	ClinGen TOPMed
CA354164598 rs1576252537	61	H>Y		No	ClinGen Ensembl
CA2570348 rs767822587	62	K>E		No	ClinGen ExAC gnomAD
CA354164625 rs1344998372	63	P>L		No	ClinGen TOPMed
CA2570349 rs138311983	64	T>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
TCGA novel	65	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA2570351 rs371721266	66	W>C		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA2570352 rs753902355	68	K>N		No	ClinGen ExAC TOPMed gnomAD
rs1194045169 CA354164705	69	K>E		No	ClinGen gnomAD
rs1252550911 CA354164735	71	L>V		No	ClinGen gnomAD
rs755537046 CA2570353	72	I>V		No	ClinGen ExAC TOPMed gnomAD
rs781184981 CA82763692	74	S>P		No	ClinGen TOPMed gnomAD
rs779234341 CA354164791	75	G>D		No	ClinGen ExAC TOPMed gnomAD
CA354164785 rs1415957411	75	G>S		No	ClinGen gnomAD
rs779234341 CA2570354	75	G>V		No	ClinGen ExAC TOPMed gnomAD
CA2570355 rs376464403	76	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA2570356 rs149572114	76	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs149572114 CA82763716	76	R>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs777463955 CA2570357	77	F>L		No	ClinGen ExAC gnomAD
CA2570358 rs199848888	78	K>E		No	ClinGen ESP ExAC TOPMed gnomAD
CA2570359 rs372973157	78	K>R		No	ClinGen 1000Genomes ESP ExAC gnomAD
CA2570360 rs372973157	78	K>T		No	ClinGen 1000Genomes ESP ExAC gnomAD
rs1311676733 CA354164866	81	D>E		No	ClinGen TOPMed gnomAD
rs1353196302 CA354164876	82	E>G		No	ClinGen gnomAD
CA82763745 rs1015707755	85	E>*		No	ClinGen TOPMed
rs769819160 CA2570363	88	S>L		No	ClinGen ExAC gnomAD
rs377168422 CA2570362	88	S>P		No	ClinGen ESP ExAC TOPMed gnomAD
rs780800119 CA2570381	89	L>S		No	ClinGen ExAC gnomAD
CA354165008 rs1314906292	90	E>K		No	ClinGen TOPMed
CA354165020 rs1350213889	91	M>T		No	ClinGen gnomAD
rs1560002860 CA354165029	92	L>P		No	ClinGen Ensembl
rs745425405 CA2570382	94	A>G		No	ClinGen ExAC gnomAD
CA354165040 rs1260394716	94	A>T		No	ClinGen gnomAD
TCGA novel	95	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs755576427 CA2570383	96	K>E		No	ClinGen ExAC TOPMed gnomAD
CA2570384 rs372529727	96	K>N		No	ClinGen ESP ExAC TOPMed gnomAD
COSM1037124 CA2570385 COSM1037123 rs749194849	100	R>*	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
CA354165085 rs1192359264	100	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA2570386 rs768647728	101	V>L		No	ClinGen ExAC gnomAD
rs1436079018 CA354165098	102	K>N		No	ClinGen gnomAD
rs1408702727 CA354165109	104	S>N		No	ClinGen gnomAD
rs1017766093 CA82765405	107	M>T		No	ClinGen TOPMed
TCGA novel	107	M>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	110	L>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA2570388 COSM389852 rs192168910 COSM389853	111	T>M	lung ovary [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC TOPMed gnomAD
rs1451248767 CA354165153	111	T>P		No	ClinGen gnomAD
rs1439868514 CA354165163	112	V>A		No	ClinGen gnomAD
rs1168155394 CA354165168	113	V>A		No	ClinGen TOPMed
rs759724441 CA2570391	118	M>V		No	ClinGen ExAC TOPMed gnomAD
rs1254666430 CA354165230	122	G>C		No	ClinGen gnomAD
CA354165240 rs1315189745	123	K>N		No	ClinGen TOPMed gnomAD
rs1306312023 CA354165238	123	K>R		No	ClinGen gnomAD
rs1218258506 CA354165250	124	K>M		No	ClinGen gnomAD
rs868701883 CA82765418	124	K>Q		No	ClinGen Ensembl
CA354165247 rs1218258506	124	K>T		No	ClinGen gnomAD
rs181265174 CA2570435	126	A>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs181265174 CA2570434	126	A>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1417313439 CA354165741	126	A>V		No	ClinGen gnomAD
rs752035060 CA82767306	127	Q>R		No	ClinGen TOPMed
rs754763531 CA2570436	129	H>Q		No	ClinGen ExAC TOPMed gnomAD
CA354165769 rs1411643459	129	H>Y		No	ClinGen gnomAD
CA354165783 rs753520254	130	E>*		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	130	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA2570437 rs753520254	130	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs759171418 CA2570438	132	L>*		No	ClinGen ExAC gnomAD
TCGA novel	134	S>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA354165842 rs764846914	135	L>F		No	ClinGen ExAC TOPMed gnomAD
CA354165835 rs1469391033	135	L>M		No	ClinGen TOPMed
rs948652646 CA82767343	139	K>N		No	ClinGen TOPMed
rs1341257535 CA354165909	141	A>V		No	ClinGen gnomAD
CA2570440 COSM1037125 rs200828064 COSM1037126	142	R>C	endometrium [Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
CA2570441 rs73188392	142	R>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs73188392 CA2570442	142	R>P		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs527415345 CA2570444	146	E>K		No	ClinGen 1000Genomes ExAC gnomAD
rs139675088 CA2570446	149	M>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA2570445 rs200080555	149	M>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs755125479 CA2570447	150	K>N		No	ClinGen ExAC gnomAD
rs1576254875 CA354166011	151	A>D		No	ClinGen Ensembl
CA82767392 rs940527824	151	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
CA2570448 rs778994095	152	K>Q		No	ClinGen ExAC gnomAD
CA2570449 rs748176562	152	K>R		No	ClinGen ExAC TOPMed gnomAD
CA2570450 rs772505072	154	E>Q		No	ClinGen ExAC gnomAD
rs773734248 CA2570451	155	E>Q		No	ClinGen ExAC gnomAD

No associated diseases with Q96A26

No regional properties for Q96A26

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for Q96A26

Functions

		Description
EC Number
Subcellular Localization	Mitochondrion membrane ; Single-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

4 GO annotations of cellular component

Name	Definition
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
integral component of membrane	The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
mitochondrial membrane	Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope.
mitochondrion	A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

No GO annotations of molecular function

Name	Definition
No GO annotations for molecular function

5 GO annotations of biological process

Name	Definition
activation of cysteine-type endopeptidase activity involved in apoptotic process	Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase in the context of an apoptotic process.
cellular response to hypoxia	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
neuron apoptotic process	Any apoptotic process in a neuron, the basic cellular unit of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the nervous system.
positive regulation of apoptotic process	Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
positive regulation of release of cytochrome c from mitochondria	Any process that increases the rate, frequency or extent of release of cytochrome c from mitochondria, the process in which cytochrome c is enabled to move from the mitochondrial intermembrane space into the cytosol, which is an early step in apoptosis and leads to caspase activation.

5 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
A6QPI4	FAM162B	Protein FAM162B	Bos taurus (Bovine)	PR
Q5T6X4	FAM162B	Protein FAM162B	Homo sapiens (Human)	PR
Q9D6U8	Fam162a	Protein FAM162A	Mus musculus (Mouse)	PR
Q9CX19	Fam162b	Protein FAM162B	Mus musculus (Mouse)	PR
Q4QQV3	Fam162a	Protein FAM162A	Rattus norvegicus (Rat)	PR

10	20	30	40	50	60
MGSLSGLRLA	AGSCFRLCER	DVSSSLRLTR	SSDLKRINGF	CTKPQESPGA	PSRTYNRVPL
70	80	90	100	110	120
HKPTDWQKKI	LIWSGRFKKE	DEIPETVSLE	MLDAAKNKMR	VKISYLMIAL	TVVGCIFMVI
130	140	150
EGKKAAQRHE	TLTSLNLEKK	ARLKEEAAMK	AKTE