AiPD: Autoinhibited Protein Database

Q5T6X4

Gene name	FAM162B (C6orf189)
Protein name	Protein FAM162B
Names
Species	Homo sapiens (Human)
KEGG Pathway	hsa:221303
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-162 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

1-162 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for Q5T6X4

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q5T6X4-F1	Predicted				AlphaFoldDB

166 variants for Q5T6X4

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA365417844 rs1428710557	2	L>V		No	ClinGen TOPMed
rs770335688 CA365417818	4	A>E		No	ClinGen ExAC TOPMed gnomAD
rs1395510963 CA365417820	4	A>S		No	ClinGen TOPMed gnomAD
CA365417824 rs1395510963	4	A>T		No	ClinGen TOPMed gnomAD
rs770335688 CA3972255	4	A>V		No	ClinGen ExAC TOPMed gnomAD
CA145950712 rs558845697	6	G>E		No	ClinGen gnomAD
rs1232535694 CA365417802	6	G>R		No	ClinGen TOPMed gnomAD
CA365417787 rs1439700987	7	S>C		No	ClinGen gnomAD
rs749020215 CA3972253	7	S>N		No	ClinGen ExAC TOPMed gnomAD
CA3972252 rs777262863	7	S>R		No	ClinGen ExAC TOPMed gnomAD
CA365417759 rs756535136	9	L>P		No	ClinGen ExAC TOPMed gnomAD
rs756535136 CA3972251	9	L>R		No	ClinGen ExAC TOPMed gnomAD
rs1049922955 CA145950673	10	R>P		No	ClinGen Ensembl
CA365417755 rs1354474475	10	R>S		No	ClinGen TOPMed
CA365417736 rs1209371790	11	L>P		No	ClinGen TOPMed
rs1268134068 CA365417732	12	G>S		No	ClinGen TOPMed
CA3972250 rs753015667	13	R>C		No	ClinGen ExAC TOPMed gnomAD
rs1247812988 CA365417707	13	R>L		No	ClinGen TOPMed
rs1247812988 CA365417710	13	R>P		No	ClinGen TOPMed
CA365417702 rs982816201	14	G>R		No	ClinGen TOPMed gnomAD
rs982816201 CA145950669	14	G>W		No	ClinGen TOPMed gnomAD
rs1394568703 CA365417649	16	T>K		No	ClinGen TOPMed
rs1394568703 CA365417645	16	T>R		No	ClinGen TOPMed
CA365417653 rs1456042650	16	T>S		No	ClinGen TOPMed
CA145950659 rs919904454	17	V>L		No	ClinGen TOPMed gnomAD
rs755407736 CA365417578	20	G>R		No	ClinGen ExAC TOPMed gnomAD
rs755407736 CA3972248	20	G>S		No	ClinGen ExAC TOPMed gnomAD
rs921667859 CA145950646	22	G>R		No	ClinGen Ensembl
CA3972247 rs752053004	23	A>T		No	ClinGen ExAC TOPMed gnomAD
CA365417484 rs1244329230	25	L>I		No	ClinGen TOPMed
rs762917190 CA365417466	26	E>K		No	ClinGen ExAC gnomAD
rs762917190 CA3972245	26	E>Q		No	ClinGen ExAC gnomAD
CA365417427 rs1376027204	27	A>V		No	ClinGen TOPMed gnomAD
rs527815452 CA3972244	28	T>A		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1188707018 CA365417390	30	R>Q		No	ClinGen TOPMed
rs762164285 CA3972243	30	R>W		No	ClinGen ExAC TOPMed gnomAD
rs1254492322 CA365417373	31	P>S		No	ClinGen TOPMed
CA365417356 rs1159425611	32	A>S		No	ClinGen gnomAD
rs1471188189 CA365417339	33	P>L		No	ClinGen TOPMed gnomAD
rs1486259184 CA365417327	34	A>G		No	ClinGen gnomAD
rs957087385 CA145950606	34	A>T		No	ClinGen TOPMed gnomAD
rs1486259184 CA365417325	34	A>V		No	ClinGen gnomAD
rs775366828 CA3972241	35	L>F		No	ClinGen ExAC gnomAD
CA365417314 rs1214004414	35	L>R		No	ClinGen gnomAD
rs775366828 CA365417321	35	L>V		No	ClinGen ExAC gnomAD
CA365417292 rs1387883064	37	P>L		No	ClinGen TOPMed
CA145950589 rs998579356	46	G>S		No	ClinGen TOPMed gnomAD
CA3972238 rs774409919	47	G>W		No	ClinGen ExAC gnomAD
rs979924187 CA145950531	48	A>D		No	ClinGen TOPMed
TCGA novel	48	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1357482615 CA365417136	49	P>L		No	ClinGen TOPMed
CA365417129 rs770518037	50	S>G		No	ClinGen ExAC TOPMed gnomAD
CA3972237 rs770518037	50	S>R		No	ClinGen ExAC TOPMed gnomAD
rs748710434 CA3972236	50	S>R		No	ClinGen ExAC TOPMed gnomAD
rs772944666 CA3972235	51	N>K		No	ClinGen ExAC TOPMed gnomAD
CA145950518 rs997168970	53	G>E		No	ClinGen TOPMed gnomAD
CA365417070 rs1420642110	55	Q>*		No	ClinGen gnomAD
CA365417071 rs1420642110	55	Q>E		No	ClinGen gnomAD
rs1218849926 CA365417058	56	G>V		No	ClinGen TOPMed
rs748513764 CA3972233	57	H>P		No	ClinGen ExAC
rs747332119 CA145950215	58	G>A		No	ClinGen ExAC gnomAD
rs747332119 CA3972211	58	G>E		No	ClinGen ExAC gnomAD
rs1243094317 CA365417050	58	G>R		No	ClinGen gnomAD
rs540446538 CA3972209	59	E>Q		No	ClinGen 1000Genomes ExAC gnomAD
rs745964030 CA3972207	60	I>V		No	ClinGen ExAC gnomAD
COSM1544624 rs778918883 CA3972206	61	H>N	lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs759517674 CA3972204	62	R>P		No	ClinGen ExAC TOPMed gnomAD
rs759517674 CA3972205	62	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA365417005 rs1244461737	63	V>F		No	ClinGen TOPMed
CA365416996 rs764374762	64	P>A		No	ClinGen ExAC gnomAD
rs918211708 CA145950169	64	P>L		No	ClinGen TOPMed
rs764374762 CA3972203	64	P>S		No	ClinGen ExAC gnomAD
rs766348617 CA3972200	65	T>K		No	ClinGen ExAC gnomAD
rs766348617 CA3972201	65	T>R		No	ClinGen ExAC gnomAD
CA3972199 rs762862107	66	Q>E		No	ClinGen ExAC gnomAD
CA3972198 rs750357032	66	Q>R		No	ClinGen ExAC gnomAD
CA365416958 rs1211838280	67	R>C		No	ClinGen gnomAD
rs764774214 CA3972197	67	R>H		No	ClinGen ExAC TOPMed gnomAD
rs761278994 CA3972196	68	R>G		No	ClinGen ExAC gnomAD
rs919743580 CA145950077	68	R>K		No	ClinGen TOPMed gnomAD
rs919743580 CA365416946	68	R>T		No	ClinGen TOPMed gnomAD
rs776294542 CA3972195	70	S>L		No	ClinGen ExAC gnomAD
rs1375399529 CA365416907	71	Q>*		No	ClinGen gnomAD
CA365416899 CA3972193 rs654128 VAR_053782	71	Q>H		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA3972192 rs775648719	72	F>L		No	ClinGen ExAC gnomAD
CA145950060 rs961440364	74	K>E		No	ClinGen TOPMed
CA365416860 rs1162855285	74	K>R		No	ClinGen TOPMed
TCGA novel	79	W>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA365416783 rs1417974400	80	T>R		No	ClinGen gnomAD
CA365416768 rs1442302984	81	G>E		No	ClinGen TOPMed
COSM1072452 CA365416759 rs746411168	82	R>C	Variant assessed as Somatic; 0.0 impact. large_intestine endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA3972189 rs746411168	82	R>S		No	ClinGen ExAC TOPMed gnomAD
CA365416742 rs1339932457	83	F>L		No	ClinGen gnomAD
rs200657943 CA3972188	84	K>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs1271113680 CA365416707	86	M>L		No	ClinGen TOPMed
CA365416700 rs1256733077	87	E>K		No	ClinGen gnomAD
CA365416691 rs771166739	88	E>*		No	ClinGen ExAC gnomAD
CA3972187 rs771166739	88	E>K		No	ClinGen ExAC gnomAD
CA145950002 rs374734432	90	P>L		No	ClinGen ESP TOPMed
rs749335067 CA3972186	90	P>T		No	ClinGen ExAC TOPMed gnomAD
CA3972184 rs756342428	91	P>H		No	ClinGen ExAC gnomAD
CA365416634 rs1357002619	93	I>F		No	ClinGen gnomAD
rs752963948 CA3972183	93	I>N		No	ClinGen ExAC TOPMed gnomAD
rs758155500 CA3972162	95	P>S		No	ClinGen ExAC gnomAD
CA3972163 rs758155500	95	P>T		No	ClinGen ExAC gnomAD
rs1371282378 CA365415876	96	E>K		No	ClinGen gnomAD
CA365415840 rs778832747 CA3972160	97	M>I		No	ClinGen ExAC gnomAD
rs1346806900 CA365415855	97	M>V		No	ClinGen TOPMed
CA3972159 rs757119929	98	I>T		No	ClinGen ExAC TOPMed gnomAD
CA365415775 rs1468062485	101	A>P		No	ClinGen TOPMed gnomAD
COSM1487160 rs1468062485 CA365415777	101	A>T	Variant assessed as Somatic; 0.0 impact. large_intestine breast [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
CA365415762 rs1321362336	101	A>V		No	ClinGen TOPMed
rs755620275 CA3972156	105	A>T		No	ClinGen ExAC gnomAD
rs1222519913 CA365415364	105	A>V		No	ClinGen TOPMed
rs201452724 CA3972155	106	R>*		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs541992567 CA3972154	106	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs1367867666 CA365415240	109	A>T		No	ClinGen gnomAD
rs1438211138 CA365415199	110	C>Y		No	ClinGen gnomAD
CA365415123 rs1369819509	112	I>V		No	ClinGen gnomAD
rs1388016888 CA365415058	114	I>F		No	ClinGen TOPMed gnomAD
rs188027180 CA3972152	114	I>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1582436751 CA365415015	115	G>*		No	ClinGen Ensembl
rs199855374 CA3972150	115	G>A		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA3972151 rs199855374	115	G>E		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
TCGA novel	116	L>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA145947769 rs746440501	117	T>K		No	ClinGen TOPMed
CA3972146 rs184749685	118	I>V		No	ClinGen 1000Genomes ExAC gnomAD
CA365414854 rs1201006095	119	I>M		No	ClinGen TOPMed gnomAD
CA3972145 rs748216736	119	I>V		No	ClinGen ExAC TOPMed gnomAD
rs41306045 CA365414845	120	A>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs41306045 CA3972144	120	A>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1250416299 CA365414822	121	C>S		No	ClinGen gnomAD
COSM3366270 rs1206564487 CA365414700	125	I>T	kidney Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA gnomAD
CA365414686 rs768863423	126	V>L		No	ClinGen ExAC TOPMed gnomAD
CA3972142 rs768863423	126	V>M		No	ClinGen ExAC TOPMed gnomAD
rs1278572691 CA365414591	129	K>N		No	ClinGen gnomAD
rs1432734511 CA365414558	130	R>S		No	ClinGen TOPMed
rs1231161883 CA365414570	130	R>T		No	ClinGen Ensembl
CA365411649 rs375099409	131	A>S		No	ClinGen ESP TOPMed gnomAD
rs375099409 CA145940746	131	A>T		No	ClinGen ESP TOPMed gnomAD
CA365411602 rs1435641122	132	V>A		No	ClinGen TOPMed
CA3972070 rs201342470	134	R>*		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs569615377 CA3972069	134	R>P		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs569615377 CA3972068 COSM1661755	134	R>Q	kidney [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC TOPMed gnomAD
CA3972067 rs751293130	137	S>C		No	ClinGen ExAC TOPMed
rs751293130 CA365411449	137	S>F		No	ClinGen ExAC TOPMed
CA365411435 rs1271171631	138	L>S		No	ClinGen gnomAD
CA3972066 rs779808676	139	T>A		No	ClinGen ExAC gnomAD
rs1379835076 CA365411376	140	S>I		No	ClinGen gnomAD
CA365411345 rs1285677851	141	W>*		No	ClinGen gnomAD
TCGA novel	141	W>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1273580999 CA365411278	143	L>W		No	ClinGen TOPMed gnomAD
rs1237006341 CA365411204	146	K>N		No	ClinGen TOPMed
TCGA novel	147	A>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA3972065 rs758853347	149	W>C		No	ClinGen ExAC TOPMed gnomAD
CA365411076 COSM1440008 rs1321535137	150	R>C	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
rs553850431 COSM3781963 CA3972064	150	R>H	pancreas [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA365411064 rs553850431	150	R>L		No	ClinGen ExAC TOPMed gnomAD
rs1319575278 CA365411055	151	E>*		No	ClinGen gnomAD
CA3972063 rs765665006	151	E>G		No	ClinGen ExAC gnomAD
rs267600776 CA145940651	156	A>S		No	ClinGen gnomAD
CA365410932 rs1296629752	157	A>G		No	ClinGen Ensembl
rs764283354 CA3972060	157	A>T		No	ClinGen ExAC gnomAD
rs1296629752 CA365410931	157	A>V		No	ClinGen Ensembl
rs760706694 CA3972059	160	K>N		No	ClinGen ExAC gnomAD
CA365410865 rs1247021923	161	A>S		No	ClinGen gnomAD

No associated diseases with Q5T6X4

No regional properties for Q5T6X4

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for Q5T6X4

Functions

		Description
EC Number
Subcellular Localization	Membrane ; Single-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

1 GO annotations of cellular component

Name	Definition
integral component of membrane	The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

No GO annotations of molecular function

Name	Definition
No GO annotations for molecular function

No GO annotations of biological process

Name	Definition
No GO annotations for biological process

4 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
A6QPI4	FAM162B	Protein FAM162B	Bos taurus (Bovine)	PR
Q96A26	FAM162A	Protein FAM162A	Homo sapiens (Human)	PR
Q9CX19	Fam162b	Protein FAM162B	Mus musculus (Mouse)	PR
Q9D6U8	Fam162a	Protein FAM162A	Mus musculus (Mouse)	PR

10	20	30	40	50	60
MLRAVGSLLR	LGRGLTVRCG	PGAPLEATRR	PAPALPPRGL	PCYSSGGAPS	NSGPQGHGEI
70	80	90	100	110	120
HRVPTQRRPS	QFDKKILLWT	GRFKSMEEIP	PRIPPEMIDT	ARNKARVKAC	YIMIGLTIIA
130	140	150	160
CFAVIVSAKR	AVERHESLTS	WNLAKKAKWR	EEAALAAQAK	AK