Q95QT2

PR
Gene name
C29E4.10
Protein name
Putative galactocerebrosidase
Names
GALCERase, Galactocerebroside beta-galactosidase, Galactosylceramidase, Galactosylceramide beta-galactosidase
Species
Caenorhabditis elegans
KEGG Pathway
cel:CELE_C29E4.10
EC number
3.2.1.46: Glycosidases, ie enzymes hydrolyzing O- and S-glycosyl compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

51-133 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q95QT2

Entry ID Method Resolution Chain Position Source
AF-Q95QT2-F1 Predicted AlphaFoldDB

No variants for Q95QT2

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q95QT2

No associated diseases with Q95QT2

1 regional properties for Q95QT2

Type Name Position InterPro Accession
domain Glycosyl hydrolase family 59, central domain 332 - 400 IPR035394

Functions

Description
EC Number 3.2.1.46 Glycosidases, ie enzymes hydrolyzing O- and S-glycosyl compounds
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
lysosome A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions.

1 GO annotations of molecular function

Name Definition
galactosylceramidase activity Catalysis of the reaction: D-galactosyl-N-acylsphingosine + H2O = D-galactose + N-acylsphingosine.

1 GO annotations of biological process

Name Definition
galactosylceramide catabolic process The chemical reactions and pathways resulting in the breakdown of galactosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of galactose by a ceramide group.

5 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P54804 GALC Galactocerebrosidase Canis lupus familiaris (Dog) (Canis familiaris) PR
P54803 GALC Galactocerebrosidase Homo sapiens (Human) PR
P54818 Galc Galactocerebrosidase Mus musculus (Mouse) PR
O02791 GALC Galactocerebrosidase Macaca mulatta (Rhesus macaque) PR
Q5SNX7 galc Galactocerebrosidase Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MFSIFIKIIL ILPSIATKTN NIDIKSWRSA QTFDGFGAVS GGGATSKLLF TYFSEKSDRK
70 80 90 100 110 120
QVLESLFNKD NGLQLLKVEM GGDDQSTEGT ESSHESEKGK ISKNNYEFQL ISEVREINPT
130 140 150 160 170 180
IPICVLPWAF PGWIGNTPYD NVTETAEYVV NWLKIGRDTW NFDTFCVGVW NERNFSESYV
190 200 210 220 230 240
KELRKILNLN GFNETLIVAG EGFRMDDSYS RLLDKRFINE YDIIGVHYPG GRIPENVQKS
250 260 270 280 290 300
GKVIWASEDY STDNRDTGEG CMARTMNWNF INGNITGMIS WHLMSAFYPQ LPWYRCGLAR
310 320 330 340 350 360
IDENKFQTEK AFHVLKYITS HVKRGWKILR ESSGRFDGGG TYVTYTNGKD STIFVETMSY
370 380 390 400 410 420
KKSLCEYSSP RPYHVKPSQL IRFKFSEIPS FQGLNMSLNF GPSKFFSKSV NSTITILLPV
430 440 450 460 470 480
NSFGILTTLP VSTPKRVTIK TPLVPLNYHD DFENYEFDEE PKFWMPQKGS WVVRNGRAVQ
490 500 510 520 530 540
KVTRPSISWC TSHIRTPYAV MAYRKKNSIL NAEVNIPKHS TAKSIILGIR SNCSGCDIEV
550 560 570 580 590 600
INCRGIFVEI EFSNKKVTIF SDFVDRSIIA EFKARRKVEF GKFYKFSIHL LDSHLFIKFG
610 620 630 640
NHHVMTSVEI PEEQLNKTNN DTLFVIGTGN FGISEWDNIS TDYFH