P54804

PR
Gene name
GALC
Protein name
Galactocerebrosidase
Names
GALCERase, Galactocerebroside beta-galactosidase, Galactosylceramidase, Galactosylceramide beta-galactosidase
Species
Canis lupus familiaris (Dog) (Canis familiaris)
KEGG Pathway
cfa:403916
EC number
3.2.1.46: Glycosidases, ie enzymes hydrolyzing O- and S-glycosyl compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

413-505 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P54804

Entry ID Method Resolution Chain Position Source
AF-P54804-F1 Predicted AlphaFoldDB

2 variants for P54804

Variant ID(s) Position Change Description Diseaes Association Provenance
158 Y>S GLD [UniProt] No
639 P>S GLD [UniProt] No

1 associated diseases with P54804

Without disease ID

1 regional properties for P54804

Type Name Position InterPro Accession
domain Glycosyl hydrolase family 59, central domain 341 - 456 IPR035394

Functions

Description
EC Number 3.2.1.46 Glycosidases, ie enzymes hydrolyzing O- and S-glycosyl compounds
Subcellular Localization
  • Lysosome
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
lysosome A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions.

1 GO annotations of molecular function

Name Definition
galactosylceramidase activity Catalysis of the reaction: D-galactosyl-N-acylsphingosine + H2O = D-galactose + N-acylsphingosine.

1 GO annotations of biological process

Name Definition
galactosylceramide catabolic process The chemical reactions and pathways resulting in the breakdown of galactosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of galactose by a ceramide group.

5 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P54803 GALC Galactocerebrosidase Homo sapiens (Human) PR
P54818 Galc Galactocerebrosidase Mus musculus (Mouse) PR
O02791 GALC Galactocerebrosidase Macaca mulatta (Rhesus macaque) PR
Q95QT2 C29E4.10 Putative galactocerebrosidase Caenorhabditis elegans PR
Q5SNX7 galc Galactocerebrosidase Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MTAAAGSAGH AAVPLLLCAL LVPGGAYVLD DSDGLGREFD GVGAVSGGGA TSRLLVNYPE
70 80 90 100 110 120
PYRSQILDYL FKPNFGASLH ILKVEIGGDG QTTDGTEPSH MHYALDENFF RGYEWWLMKE
130 140 150 160 170 180
AKKRNPNIIL MGLPWSFPGW IGKGFNWPYV NLQLTAYYIM TWIVGAKHYH DLDIDYIGIW
190 200 210 220 230 240
NERSFDINYI KVLRRMLNYQ GLDRVKIIAS DNLWEPISAS MLLDSELLKV IDVIGAHYPG
250 260 270 280 290 300
THTVKDAKLT KKKLWSSEDF STLNSDVGAG CLGRILNQNY VNGYMTATIA WNLVASYYEQ
310 320 330 340 350 360
LPYGRCGLMT AQEPWSGHYV VESPIWVSAH TTQFTQPGWY YLKTVGHLEK GGSYVALTDG
370 380 390 400 410 420
LGNLTIIVET MSHKQSACIR PFLPYFNVSR QFATFVLKGS FSEIPELQVW YTKLGKPSER
430 440 450 460 470 480
YLFKQLDSLW LLDSSSTFTL ELQEDEIFTL TTLTVGSKGS YPLPPKSEPF PQIYEDDFDV
490 500 510 520 530 540
DYPFFSEAPN FADQTGVFEY FTNIEDPGEH RFTLRQVLNQ RPITWAADAY NTISIIGDYK
550 560 570 580 590 600
WSNLTVRCDV YIETPEKGGV FIAGRVNKGG ILIRSARGIF FWIFANGTYR VTGDLAGWVI
610 620 630 640 650 660
YALGRVDVTA KKWYTLTLII KGRLSSGMLN GKTVWKNIPV SFPKNGWAAI GTHSFEFAQF
DNFHVEATR