O02791

PR
Gene name
GALC
Protein name
Galactocerebrosidase
Names
GALCERase, Galactocerebroside beta-galactosidase, Galactosylceramidase, Galactosylceramide beta-galactosidase
Species
Macaca mulatta (Rhesus macaque)
KEGG Pathway
mcc:693322
EC number
3.2.1.46: Glycosidases, ie enzymes hydrolyzing O- and S-glycosyl compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-56 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O02791

Entry ID Method Resolution Chain Position Source
AF-O02791-F1 Predicted AlphaFoldDB

No variants for O02791

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O02791

No associated diseases with O02791

No regional properties for O02791

Type Name Position InterPro Accession
No domain, repeats, and functional sites for O02791

Functions

Description
EC Number 3.2.1.46 Glycosidases, ie enzymes hydrolyzing O- and S-glycosyl compounds
Subcellular Localization
  • Lysosome
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
lysosome A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions.

1 GO annotations of molecular function

Name Definition
galactosylceramidase activity Catalysis of the reaction: D-galactosyl-N-acylsphingosine + H2O = D-galactose + N-acylsphingosine.

2 GO annotations of biological process

Name Definition
galactosylceramide catabolic process The chemical reactions and pathways resulting in the breakdown of galactosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of galactose by a ceramide group.
myelination The process in which myelin sheaths are formed and maintained around neurons. Oligodendrocytes in the brain and spinal cord and Schwann cells in the peripheral nervous system wrap axons with compact layers of their plasma membrane. Adjacent myelin segments are separated by a non-myelinated stretch of axon called a node of Ranvier.

5 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P54804 GALC Galactocerebrosidase Canis lupus familiaris (Dog) (Canis familiaris) PR
P54803 GALC Galactocerebrosidase Homo sapiens (Human) PR
P54818 Galc Galactocerebrosidase Mus musculus (Mouse) PR
Q95QT2 C29E4.10 Putative galactocerebrosidase Caenorhabditis elegans PR
Q5SNX7 galc Galactocerebrosidase Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MAEWLLSASR QRRVKAMTAA AGSAGRAAVP FLLCALLAPG GAYVLDDSDG LGREFDGIGA
70 80 90 100 110 120
VSGGGATSRL LVNYPEPYRS QILDYLFKPN FGASLHILKV EIGGDGQTTD GTEPSHMHYA
130 140 150 160 170 180
LDENYFRGYE WWLMKEAKKR NPNITLIGLP WSFPGWLGKG FDWPYVNLQL TAYYVVTWIV
190 200 210 220 230 240
GAKRYHDLDI DYIGIWNERS YNANYIKILR KMLNSQGLQR VKIIASDNLW ESISAAMLLD
250 260 270 280 290 300
AELFKVVDVI GAHYPGTHSV KDARLTGKKL WSSEDFSTLN SDTGAGCWGR ILNQNYVNGY
310 320 330 340 350 360
MTSTIAWNLV ASYYEQLPYG RCGLMTAQEP WSGHYVVESP VWVSAHTTQF TQPGWYYLKT
370 380 390 400 410 420
VGHLEKGGSY VALTDGLGNL TIIIETMSHK HSKCIRPFLP YFNVSQQFAT FVLKGSFSEI
430 440 450 460 470 480
PELQVWYTKL GKTSERFLFK QLDSLWLLDS NGSFTLKLQE DELFTLTTLT TGRKGSYLPP
490 500 510 520 530 540
PKSQRFPSTY KDDFNVDYPF FSEAPNFADQ TGVFEYFTNM EDPGEHHFTL RQVLNQRPIT
550 560 570 580 590 600
WAADASNTIS IIGDYNWTNL TIKCDVYIET PDTGGVFIAG RVNKGGILIR SARGIFFWIF
610 620 630 640 650 660
ANGSYRVTGD LAGWIIYALG HVEVTAKTWY TLTLTIKGRF ASGMLNDKSL WTDIPVNFPK
670 680
NGWAAIGTHS FEFAQFDNFH VEATR