Q5SNX7

PR
Gene name
galc
Protein name
Galactocerebrosidase
Names
GALCERase, Galactosylceramidase
Species
Danio rerio (Zebrafish) (Brachydanio rerio)
KEGG Pathway
dre:449649
EC number
3.2.1.46: Glycosidases, ie enzymes hydrolyzing O- and S-glycosyl compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

55-127 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5SNX7

Entry ID Method Resolution Chain Position Source
AF-Q5SNX7-F1 Predicted AlphaFoldDB

No variants for Q5SNX7

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5SNX7

No associated diseases with Q5SNX7

1 regional properties for Q5SNX7

Type Name Position InterPro Accession
domain Glycosyl hydrolase family 59, central domain 334 - 449 IPR035394

Functions

Description
EC Number 3.2.1.46 Glycosidases, ie enzymes hydrolyzing O- and S-glycosyl compounds
Subcellular Localization
  • Lysosome
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
lysosome A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions.

1 GO annotations of molecular function

Name Definition
galactosylceramidase activity Catalysis of the reaction: D-galactosyl-N-acylsphingosine + H2O = D-galactose + N-acylsphingosine.

1 GO annotations of biological process

Name Definition
galactosylceramide catabolic process The chemical reactions and pathways resulting in the breakdown of galactosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of galactose by a ceramide group.

5 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P54804 GALC Galactocerebrosidase Canis lupus familiaris (Dog) (Canis familiaris) PR
P54803 GALC Galactocerebrosidase Homo sapiens (Human) PR
P54818 Galc Galactocerebrosidase Mus musculus (Mouse) PR
O02791 GALC Galactocerebrosidase Macaca mulatta (Rhesus macaque) PR
Q95QT2 C29E4.10 Putative galactocerebrosidase Caenorhabditis elegans PR
10 20 30 40 50 60
MQTHNFLCII SVILGCSAQF YVIDDRIGLG REFDGIGGLS GGGATSRLLV NYEEPYRSQI
70 80 90 100 110 120
LDYLFKPNFG ASLHILKVEI GGDAQTTDGT EPSHMHSKDE GNFFRGYEWW LMKEAKKRNP
130 140 150 160 170 180
NIKLIGLPWA FPGWVGYGTQ WPYFFPNVTA NYVITWVMGA KQHHNLDIDY IGIWNEKAFD
190 200 210 220 230 240
PTYIKVLRDA LDRAGFTNIG IIAADGDWSI ASAMLDDPYL NDAVEVIGVH YPGTNTVKEA
250 260 270 280 290 300
LLTERKLWSS EDYSTYNDDI GAGCWARILN QNYVNGKMTS TISWNVIASY YENLSFGRDG
310 320 330 340 350 360
LMTAEEPWSG HYIVESPIWM TAHTTQFTQP GWFYLQTVGK LNHGGSYVAL TDRKGNLTII
370 380 390 400 410 420
IETMTHEHSQ CIRPPLPHFD VSPQIATFEL KGSFAHLADL QVWYSKLDFK SGNGTLFKQL
430 440 450 460 470 480
RPIRAHNGLL SLKLDVDEVF TITTVTTAQR GFYPEPPKSC PFPKNYTDDF TIDNPPFSEA
490 500 510 520 530 540
PYFADQTGVF EYFRNTTDNS SHAFTLRQVV TERPVAWAKD ADQTISIIGD YSWSDVNVSC
550 560 570 580 590 600
DVFIETPKTG GVFLAARVDQ GGESVRQAKG VFYWIYANGT YRVTNDIGGK RVLAEGLSGT
610 620 630 640 650
KAGVWYTLTL SVKGYFATGS LNGFPLWKNA AVLEPKSGWA ALGTLSFEYA QFDNFNVIAG