Q95NM6

PR
Gene name
cps-6 (C41D11.8)
Protein name
Endonuclease G, mitochondrial
Names
Endo G, Ced-3 protease suppressor 6
Species
Caenorhabditis elegans
KEGG Pathway
cel:CELE_C41D11.8
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

7-148 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

5 structures for Q95NM6

Entry ID Method Resolution Chain Position Source
3S5B X-ray 180 A A/B 63-303 PDB
4QN0 X-ray 274 A A/B/C/D 64-302 PDB
5GKC X-ray 189 A A/B 63-305 PDB
5GKP X-ray 230 A A/B 63-305 PDB
AF-Q95NM6-F1 Predicted AlphaFoldDB

No variants for Q95NM6

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q95NM6

No associated diseases with Q95NM6

3 regional properties for Q95NM6

Type Name Position InterPro Accession
domain DNA/RNA non-specific endonuclease 66 - 293 IPR001604
active_site DNA/RNA non-specific endonuclease, active site 145 - 153 IPR018524
domain Extracellular Endonuclease, subunit A 83 - 293 IPR020821

Functions

Description
EC Number
Subcellular Localization
  • Mitochondrion
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

8 GO annotations of molecular function

Name Definition
double-stranded DNA endodeoxyribonuclease activity Catalysis of the hydrolysis of ester linkages within a double-stranded deoxyribonucleic acid molecule by creating internal breaks.
endodeoxyribonuclease activity Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid by creating internal breaks.
endonuclease activity Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks.
endoribonuclease activity Catalysis of the hydrolysis of ester linkages within ribonucleic acid by creating internal breaks.
metal ion binding Binding to a metal ion.
protein homodimerization activity Binding to an identical protein to form a homodimer.
sequence-specific DNA binding Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
single-stranded DNA endodeoxyribonuclease activity Catalysis of the hydrolysis of ester linkages within a single-stranded deoxyribonucleic acid molecule by creating internal breaks.

3 GO annotations of biological process

Name Definition
apoptotic DNA fragmentation The cleavage of DNA during apoptosis, which usually occurs in two stages: cleavage into fragments of about 50 kbp followed by cleavage between nucleosomes to yield 200 bp fragments.
DNA catabolic process, endonucleolytic The chemical reactions and pathways resulting in the breakdown of DNA, involving the hydrolysis of internal 3',5'-phosphodiester bonds in one or two strands of deoxyribonucleotides.
RNA catabolic process The chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P08466 NUC1 Mitochondrial nuclease Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
Q9Y2C4 EXOG Nuclease EXOG, mitochondrial Homo sapiens (Human) PR
Q8C163 Exog Nuclease EXOG, mitochondrial Mus musculus (Mouse) PR
10 20 30 40 50 60
MIGKVAGTAA IAGISFLAGK YSNDDLPIFR NVQSATNVPM NQIQVSEPMT VKPASLNADA
70 80 90 100 110 120
MGPSRSAEIM KHGYPGFTNV RTYEDFVLSY DYKTRTAHWV CEHLTPERLK HAEGVDRKLC
130 140 150 160 170 180
EFKPDITFPQ KFLSQNTDYK CSGFDRGHLA AAGNHRKSQL AVDQTFYLSN MSPQVGRGFN
190 200 210 220 230 240
RDKWNDLEMH CRRVAKKMIN SYIITGPLYL PKLEGDGKKY IKYQVIGDNN VAVPTHFFKV
250 260 270 280 290 300
ALFEVTPGKF ELESYILPNA VIEDTVEISK FHVPLDAVER SAGLEIFARL DPKSIVKENG
AKKGGLLW