AiPD: Autoinhibited Protein Database

Gene name	Exog (Endogl1)
Protein name	Nuclease EXOG, mitochondrial
Names	Endonuclease G-like 1, Endo G-like 1
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:208194
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

1-179 (Predicted disordered autoinhibitory region) PR

1-179 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q8C163-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs3389077592	23	G>R	No	EVA
rs3412942493	32	G>R	No	EVA
rs30522200	38	F>L	No	EVA
rs29592742	39	F>I	No	EVA
rs29592742	39	F>L	No	EVA
rs3400837852	45	E>D	No	EVA
rs228178723	45	E>G	No	EVA
rs3389026694	54	H>Y	No	EVA
rs3389082382	69	L>I	No	EVA
rs50591130	96	E>D	No	EVA
rs3389080995	153	A>T	No	EVA
rs3389080997	179	E>Q	No	EVA
rs3389070306	209	T>A	No	EVA
rs3400649545	222	V>L	No	EVA
rs3389062346	239	E>D	No	EVA
rs242968355	245	A>V	No	EVA
rs3389083667	273	E>K	No	EVA
rs47311353	283	R>C	No	EVA
rs3389080970	316	I>F	No	EVA
rs3389083614	331	A>T	No	EVA
rs244038522	338	E>K	No	EVA

Type	Name	Position	InterPro Accession
domain	DNA/RNA non-specific endonuclease	62 - 287	IPR001604
domain	Extracellular Endonuclease, subunit A	77 - 287	IPR020821
domain	EXOG, C-terminal	302 - 350	IPR041003

		Description
EC Number
Subcellular Localization	Mitochondrion inner membrane
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
mitochondrial inner membrane	The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
mitochondrion	A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
protein-containing complex	A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.

Name	Definition
5'-3' exonuclease activity	Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 5' end.
endonuclease activity	Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks.
endoribonuclease activity	Catalysis of the hydrolysis of ester linkages within ribonucleic acid by creating internal breaks.
metal ion binding	Binding to a metal ion.
nucleic acid binding	Binding to a nucleic acid.
single-stranded DNA endodeoxyribonuclease activity	Catalysis of the hydrolysis of ester linkages within a single-stranded deoxyribonucleic acid molecule by creating internal breaks.

Name	Definition
apoptotic DNA fragmentation	The cleavage of DNA during apoptosis, which usually occurs in two stages: cleavage into fragments of about 50 kbp followed by cleavage between nucleosomes to yield 200 bp fragments.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P08466	NUC1	Mitochondrial nuclease	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	PR
Q9Y2C4	EXOG	Nuclease EXOG, mitochondrial	Homo sapiens (Human)	PR
Q95NM6	cps-6	Endonuclease G, mitochondrial	Caenorhabditis elegans	PR