Q94A28

PR
Gene name
ACO2
Protein name
Aconitate hydratase 2, mitochondrial
Names
Aconitase 2, mACO2, Citrate hydro-lyase 2
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT4G26970
EC number
4.2.1.3: Hydro-lyases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-140 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q94A28

Entry ID Method Resolution Chain Position Source
AF-Q94A28-F1 Predicted AlphaFoldDB

48 variants for Q94A28

Variant ID(s) Position Change Description Diseaes Association Provenance
ENSVATH14300608 5 A>S No 1000Genomes
tmp_4_13543119_A_T 15 R>W No 1000Genomes
tmp_4_13543146_G_A 24 A>T No 1000Genomes
tmp_4_13543150_C_T 25 S>F No 1000Genomes
ENSVATH00540379 25 S>T No 1000Genomes
ENSVATH12251899 27 E>D No 1000Genomes
tmp_4_13543159_C_A 28 T>K No 1000Genomes
tmp_4_13543165_C_T 30 S>L No 1000Genomes
ENSVATH02929038 35 S>P No 1000Genomes
ENSVATH06782515 36 A>S No 1000Genomes
ENSVATH02929039 40 R>L No 1000Genomes
ENSVATH00540381 43 T>S No 1000Genomes
ENSVATH02929042 57 R>Q No 1000Genomes
tmp_4_13543263_A_C 63 T>P No 1000Genomes
tmp_4_13543264_C_G 63 T>R No 1000Genomes
ENSVATH00540383 75 A>T No 1000Genomes
tmp_4_13543336_T_G 87 V>G No 1000Genomes
tmp_4_13543369_T_G 98 M>R No 1000Genomes
ENSVATH00540385 107 I>L No 1000Genomes
ENSVATH00540386 126 P>T No 1000Genomes
ENSVATH06782529 159 D>N No 1000Genomes
tmp_4_13543969_T_A 169 N>K No 1000Genomes
tmp_4_13543971_C_G 170 T>R No 1000Genomes
tmp_4_13544477_G_A 278 V>I No 1000Genomes
tmp_4_13545036_G_A 365 V>M No 1000Genomes
ENSVATH00540404 439 R>G No 1000Genomes
ENSVATH12252035 488 A>T No 1000Genomes
tmp_4_13546125_C_T 506 P>S No 1000Genomes
tmp_4_13546145_A_T 512 E>D No 1000Genomes
tmp_4_13546443_C_T 585 R>* No 1000Genomes
tmp_4_13546616_G_A 615 D>N No 1000Genomes
tmp_4_13546635_C_A 621 A>D No 1000Genomes
ENSVATH06782574 624 G>E No 1000Genomes
ENSVATH02929119 676 I>L No 1000Genomes
ENSVATH00540413 679 R>G No 1000Genomes
ENSVATH02929120 680 S>R No 1000Genomes
ENSVATH02929122 683 K>E No 1000Genomes
tmp_4_13547341_G_A 715 E>K No 1000Genomes
ENSVATH12252040 720 G>E No 1000Genomes
ENSVATH14300652 722 P>H No 1000Genomes
ENSVATH00540415 740 N>S No 1000Genomes
ENSVATH06782586 800 R>L No 1000Genomes
tmp_4_13547712_A_T 838 E>D No 1000Genomes
tmp_4_13548136_A_G 927 E>G No 1000Genomes
tmp_4_13548195_G_A 947 D>N No 1000Genomes
ENSVATH14300654 970 F>S No 1000Genomes
ENSVATH12252097 994 A>T No 1000Genomes
ENSVATH12252098 994 A>V No 1000Genomes

No associated diseases with Q94A28

No regional properties for Q94A28

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q94A28

Functions

Description
EC Number 4.2.1.3 Hydro-lyases
Subcellular Localization
  • Mitochondrion
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

5 GO annotations of molecular function

Name Definition
4 iron, 4 sulfur cluster binding Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands.
aconitate hydratase activity Catalysis of the reaction: citrate = isocitrate. The reaction occurs in two steps: (1) citrate = cis-aconitate + H2O, (2) cis-aconitate + H2O = isocitrate. This reaction is the interconversion of citrate and isocitrate via the labile, enzyme-bound intermediate cis-aconitate. Water is removed from one part of the citrate molecule and added back to a different atom to form isocitrate.
citrate dehydratase activity Catalysis of the reaction: citrate = cis-aconitate + H2O.
copper ion binding Binding to a copper (Cu) ion.
iron-responsive element binding Binding to an iron-responsive element, a regulatory sequence found in the 5'- and 3'-untranslated regions of mRNAs encoding many iron-binding proteins.

6 GO annotations of biological process

Name Definition
citrate metabolic process The chemical reactions and pathways involving citrate, 2-hydroxy-1,2,3-propanetricarboyxlate. Citrate is widely distributed in nature and is an important intermediate in the TCA cycle and the glyoxylate cycle.
glyoxylate cycle A modification of the TCA cycle occurring in some plants and microorganisms, in which isocitrate is cleaved to glyoxylate and succinate. Glyoxylate can then react with acetyl-CoA to form malate.
isocitrate metabolic process The chemical reactions and pathways involving isocitrate, the anion of isocitric acid, 1-hydroxy-1,2,3-propanetricarboxylic acid. Isocitrate is an important intermediate in the TCA cycle and the glycoxylate cycle.
response to iron ion starvation Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of iron ion.
response to oxidative stress Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
tricarboxylic acid cycle A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P21399 ACO1 Cytoplasmic aconitate hydratase Homo sapiens (Human) PR
P28271 Aco1 Cytoplasmic aconitate hydratase Mus musculus (Mouse) PR
Q23500 aco-1 Cytoplasmic aconitate hydratase Caenorhabditis elegans PR
10 20 30 40 50 60
MYRRATSGVR SASARLSSSL SRIASSETAS VSAPSASSLR NQTNRSKSFS SALRSFRVCS
70 80 90 100 110 120
ASTRWSHGGS WGSPASLRAQ ARNSTPVMEK FERKYATMAS EHSYKDILTS LPKPGGGEYG
130 140 150 160 170 180
KYYSLPALND PRIDKLPFSV RILLESAIRN CDNYQVTKDD VEKILDWENT STKQVEIAFK
190 200 210 220 230 240
PARVILQDFT GVPVLVDLAS MRDAVKNLGS DPSKINPLVP VDLVVDHSIQ VDFARSEDAA
250 260 270 280 290 300
QKNLELEFKR NKERFTFLKW GSTAFQNMLV VPPGSGIVHQ VNLEYLGRVV FNSKGFLYPD
310 320 330 340 350 360
SVVGTDSHTT MIDGLGVAGW GVGGIEAEAA MLGQPMSMVL PGVVGFKLDG KLKEGVTATD
370 380 390 400 410 420
LVLTVTQILR KHGVVGKFVE FYGEGMSELS LADRATIANM SPEYGATMGF FPVDHVTLEY
430 440 450 460 470 480
LKLTGRSDET VSMIESYLRA NNMFVDYNEP QQERAYTSYL QLDLGHVEPC ISGPKRPHDR
490 500 510 520 530 540
VPLKDMKADW HACLDNPVGF KGFAVPKEKQ EEVVKFSYNG QPAEIKHGSV VIAAITSCTN
550 560 570 580 590 600
TSNPSVMIGA ALVAKKASDL GLKVKPWVKT SLAPGSRVVE KYLDRSGLRE SLTKQGFEIV
610 620 630 640 650 660
GYGCTTCIGN SGNLDPEVAS AIEGTDIIPA AVLSGNRNFE GRVHPQTRAN YLASPPLVVA
670 680 690 700 710 720
YALAGTVDID FEKEPIGTRS DGKSVYLRDV WPSNEEVAQV VQYSVLPSMF KSSYETITEG
730 740 750 760 770 780
NPLWNELSAP SSTLYSWDPN STYIHEPPYF KNMTANPPGP REVKDAYCLL NFGDSVTTDH
790 800 810 820 830 840
ISPAGNIQKT SPAAKFLMDR GVISEDFNSY GSRRGNDEVM ARGTFANIRI VNKLLKGEVG
850 860 870 880 890 900
PNTVHIPTGE KLSVFDAASK YKTAEQDTII LAGAEYGSGS SRDWAAKGPL LLGVKAVIAK
910 920 930 940 950 960
SFERIHRSNL AGMGIIPLCF KAGEDAETLG LTGHERYTVH LPTKVSDIRP GQDVTVTTDS
970 980 990
GKSFVCTLRF DTEVELAYYD HGGILPYVIR SLSAK