Q23500

PR
Gene name
aco-1 (gei-22, ZK455.1)
Protein name
Cytoplasmic aconitate hydratase
Names
Aconitase, Citrate hydro-lyase, Gex-3-interacting protein 22
Species
Caenorhabditis elegans
KEGG Pathway
cel:CELE_ZK455.1
EC number
4.2.1.3: Hydro-lyases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

588-666 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q23500

Entry ID Method Resolution Chain Position Source
AF-Q23500-F1 Predicted AlphaFoldDB

No variants for Q23500

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q23500

No associated diseases with Q23500

5 regional properties for Q23500

Type Name Position InterPro Accession
domain Aconitase A/isopropylmalate dehydratase small subunit, swivel domain 691 - 818 IPR000573
domain Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha domain 61 - 563 IPR001030
binding_site Aconitase family, 4Fe-4S cluster binding site 428 - 444 IPR018136-1
binding_site Aconitase family, 4Fe-4S cluster binding site 494 - 507 IPR018136-2
domain Aconitase A, swivel domain 668 - 835 IPR044137

Functions

Description
EC Number 4.2.1.3 Hydro-lyases
Subcellular Localization
  • Cytoplasm, cytosol
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

4 GO annotations of molecular function

Name Definition
4 iron, 4 sulfur cluster binding Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands.
aconitate hydratase activity Catalysis of the reaction: citrate = isocitrate. The reaction occurs in two steps: (1) citrate = cis-aconitate + H2O, (2) cis-aconitate + H2O = isocitrate. This reaction is the interconversion of citrate and isocitrate via the labile, enzyme-bound intermediate cis-aconitate. Water is removed from one part of the citrate molecule and added back to a different atom to form isocitrate.
citrate dehydratase activity Catalysis of the reaction: citrate = cis-aconitate + H2O.
metal ion binding Binding to a metal ion.

4 GO annotations of biological process

Name Definition
cellular iron ion homeostasis Any process involved in the maintenance of an internal steady state of iron ions at the level of a cell.
citrate metabolic process The chemical reactions and pathways involving citrate, 2-hydroxy-1,2,3-propanetricarboyxlate. Citrate is widely distributed in nature and is an important intermediate in the TCA cycle and the glyoxylate cycle.
tricarboxylic acid cycle A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle.
tricarboxylic acid metabolic process The chemical reactions and pathways involving dicarboxylic acids, any organic acid containing three carboxyl (COOH) groups or anions (COO-).

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P21399 ACO1 Cytoplasmic aconitate hydratase Homo sapiens (Human) PR
P28271 Aco1 Cytoplasmic aconitate hydratase Mus musculus (Mouse) PR
Q94A28 ACO2 Aconitate hydratase 2, mitochondrial Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MAFNNLIRNL AIGDNVYKYF DLNGLNDARY NELPISIKYL LEAAVRHCDE FHVLKKDVET
70 80 90 100 110 120
ILDWKNSQRN QAEIPFKPAR VILQDFTGVP AVVDLAAMRD AVQNMGADPA KINPVCPVDL
130 140 150 160 170 180
VIDHSVQVDH YGNLEALAKN QSIEFERNRE RFNFLKWGSK AFDNLLIVPP GSGIVHQVNL
190 200 210 220 230 240
EYLARTVFVG KDGVLYPDSV VGTDSHTTMI DGSGVLGWGV GGIEAEAVML GQPISMVIPE
250 260 270 280 290 300
VIGYELVGTL SDTVTSTDLV LTITKNLRDL GVVGKFVEFF GTGVASLSIA DRATIANMCP
310 320 330 340 350 360
EYGATIGFFP VDSRTIDYLT QTGRDTDYTQ RVEQYLKSVG MFVNFTDDSY RPTYTTTLKL
370 380 390 400 410 420
DLGSVVPSVS GPKRPHDRVE LASLAQDFSK GLTDKISFKA FGLKPEDATK SVTITNHGRT
430 440 450 460 470 480
AELTHGSVVI AAITSCTNTS NPSVMLAAGL VAKKAVELGL NVQPYVKTSL SPGSGVVTKY
490 500 510 520 530 540
LEASGLLPYL EKIGFNIAGY GCMTCIGNSG PLDEPVTKAI EENNLVVAGV LSGNRNFEGR
550 560 570 580 590 600
IHPHVRANYL ASPPLAVLYS IIGNVNVDIN GVLAVTPDGK EIRLADIWPT RKEVAKFEEE
610 620 630 640 650 660
FVKPQFFREV YANIELGSTE WQQLECPAVK LYPWDDASTY IKKVPFFDGM TSELPSQSDI
670 680 690 700 710 720
VNAHVLLNLG DSVTTDHISP AGSISKTSPA ARFLAGRGVT PRDFNTYGAR RGNDEIMARG
730 740 750 760 770 780
TFANIRLVNK LASKVGPITL HVPSGEELDI FDAAQKYKDA GIPAIILAGK EYGCGSSRDW
790 800 810 820 830 840
AAKGPFLQGV KAVIAESFER IHRSNLIGMG IIPFQYQAGQ NADSLGLTGK EQFSIGVPDD
850 860 870 880
LKPGQLIDVN VSNGSVFQVI CRFDTEVELT YYRNGGILQY MIRKLIQ