Q924Z4

PR
Gene name
Cers2
Protein name
Ceramide synthase 2
Names
CerS2, LAG1 longevity assurance homolog 2, Sphingosine N-acyltransferase CERS2, Translocating chain-associating membrane protein homolog 3, TRAM homolog 3, Tumor metastasis-suppressor gene 1 protein, Very-long-chain ceramide synthase CERS2
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:76893
EC number
2.3.1.24: Transferring groups other than amino-acyl groups
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

47-153 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q924Z4

Entry ID Method Resolution Chain Position Source
AF-Q924Z4-F1 Predicted AlphaFoldDB

17 variants for Q924Z4

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3393374426 2 L>H No EVA
rs3388648700 29 D>E No EVA
rs3388645092 46 A>T No EVA
rs3388637137 49 F>I No EVA
rs3388650630 49 F>S No EVA
rs3388629067 50 L>H No EVA
rs3388644562 122 R>L No EVA
rs3392965543 136 A>T No EVA
rs3388650596 171 P>H No EVA
rs3388645068 205 D>E No EVA
rs3388651711 228 Y>H No EVA
rs3388645095 243 D>E No EVA
rs3388641333 300 F>V No EVA
rs3388641414 329 K>Q No EVA
rs3388629053 340 R>G No EVA
rs3388647495 356 A>V No EVA
rs3388629054 378 K>R No EVA

No associated diseases with Q924Z4

2 regional properties for Q924Z4

Type Name Position InterPro Accession
domain Homeobox domain 67 - 128 IPR001356
domain TRAM/LAG1/CLN8 homology domain 131 - 332 IPR006634

Functions

Description
EC Number 2.3.1.24 Transferring groups other than amino-acyl groups
Subcellular Localization
  • Endoplasmic reticulum membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

3 GO annotations of molecular function

Name Definition
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
N-acyltransferase activity Catalysis of the transfer of an acyl group to a nitrogen atom on the acceptor molecule.
sphingosine N-acyltransferase activity Catalysis of the reaction: acyl-CoA + sphingosine = CoA + N-acylsphingosine.

7 GO annotations of biological process

Name Definition
ceramide biosynthetic process The chemical reactions and pathways resulting in the formation of ceramides, any N-acylated sphingoid.
negative regulation of axon regeneration Any process that stops, prevents, or reduces the frequency, rate or extent of axon regeneration.
negative regulation of Schwann cell migration Any process that stops, prevents or reduces the frequency, rate or extent of Schwann cell migration.
negative regulation of Schwann cell proliferation Any process that decreases the frequency or extent of the multiplication or reproduction of Schwann cells, resulting in the expansion of their population. Schwann cells are a type of glial cell in the peripheral nervous system.
negative regulation of Schwann cell proliferation involved in axon regeneration Any process that stops, prevents or reduces the frequency, rate or extent of Schwann cell proliferation involved in axon regeneration.
regulation of lipid metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving lipids.
sphingolipid biosynthetic process The chemical reactions and pathways resulting in the formation of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid).

12 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P38703 LAG1 Ceramide synthase LAG1 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
Q5E9R6 CERS4 Ceramide synthase 4 Bos taurus (Bovine) PR
Q3ZBF8 CERS2 Ceramide synthase 2 Bos taurus (Bovine) PR
Q8IU89 CERS3 Ceramide synthase 3 Homo sapiens (Human) PR
Q8N5B7 CERS5 Ceramide synthase 5 Homo sapiens (Human) PR
Q6ZMG9 CERS6 Ceramide synthase 6 Homo sapiens (Human) PR
Q96G23 CERS2 Ceramide synthase 2 Homo sapiens (Human) PR
Q8C172 Cers6 Ceramide synthase 6 Mus musculus (Mouse) PR
Q9D6J1 Cers4 Ceramide synthase 4 Mus musculus (Mouse) PR
Q9D6K9 Cers5 Ceramide synthase 5 Mus musculus (Mouse) PR
Q6YWS8 Os02g0728300 ASC1-like protein 2 Oryza sativa subsp japonica (Rice) PR
G5ED45 hyl-1 Ceramide synthase hyl-1 Caenorhabditis elegans PR
10 20 30 40 50 60
MLQTLYDYFW WERLWLPVNL TWADLEDKDG RVYAKASDLY ITLPLALLFL VIRYFFELYV
70 80 90 100 110 120
ATPLAALLNV KEKTRLRAPP NATLEHFYQT SGKQPKQVEV DLLSRQSGLS GRQVERWFRR
130 140 150 160 170 180
RRNQDRPSLL KKFREASWRF TYYLIAFVAG MAVTVDKPWF YDLRKVWEGY PIQSIIPSQY
190 200 210 220 230 240
WYYMIELSFY WSLLFSIASD VKRKDFKEQI IHHVATIILL CFSWFANYVR AGTLIMALHD
250 260 270 280 290 300
ASDYLLESAK MFNYAGWKNT CNNLFIVFAI VFIITRLVIM PFWILHCTMI YPLELYPAFF
310 320 330 340 350 360
GYYFFNFMMA VLQMLHIFWA YFILRMAHKF ITGKLIEDER SDREETESSE GEETAAGAGA
370
KSRLLANGHP ILNNNHPKND