P38703
Gene name |
LAG1 (YHL003C) |
Protein name |
Ceramide synthase LAG1 |
Names |
Longevity assurance factor 1, Longevity assurance gene 1 protein, Longevity assurance protein 1, Very-long-chain ceramide synthase LAG1 |
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YHL003C |
EC number |
2.3.1.297: Transferring groups other than amino-acyl groups |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P38703
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P38703-F1 | Predicted | AlphaFoldDB |
2 variants for P38703
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s08-101508 | 124 | D>E | No | SGRP | |
| s08-101242 | 213 | V>D | No | SGRP |
No associated diseases with P38703
Functions
| Description | ||
|---|---|---|
| EC Number | 2.3.1.297 | Transferring groups other than amino-acyl groups |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| acyl-CoA ceramide synthase complex | A protein complex that catalyzes the reaction acyl-CoA + sphingosine = CoA + N-acylsphingosine. In S. cerevisiae it contains three subunits: lag1, lac1 and lip1. |
| endoplasmic reticulum | The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). |
| endoplasmic reticulum membrane | The lipid bilayer surrounding the endoplasmic reticulum. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| N-acyltransferase activity | Catalysis of the transfer of an acyl group to a nitrogen atom on the acceptor molecule. |
| sphingosine N-acyltransferase activity | Catalysis of the reaction: acyl-CoA + sphingosine = CoA + N-acylsphingosine. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| ceramide biosynthetic process | The chemical reactions and pathways resulting in the formation of ceramides, any N-acylated sphingoid. |
12 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q3ZBF8 | CERS2 | Ceramide synthase 2 | Bos taurus (Bovine) | PR |
| Q5E9R6 | CERS4 | Ceramide synthase 4 | Bos taurus (Bovine) | PR |
| Q8IU89 | CERS3 | Ceramide synthase 3 | Homo sapiens (Human) | PR |
| Q96G23 | CERS2 | Ceramide synthase 2 | Homo sapiens (Human) | PR |
| Q6ZMG9 | CERS6 | Ceramide synthase 6 | Homo sapiens (Human) | PR |
| Q8N5B7 | CERS5 | Ceramide synthase 5 | Homo sapiens (Human) | PR |
| Q924Z4 | Cers2 | Ceramide synthase 2 | Mus musculus (Mouse) | PR |
| Q9D6J1 | Cers4 | Ceramide synthase 4 | Mus musculus (Mouse) | PR |
| Q8C172 | Cers6 | Ceramide synthase 6 | Mus musculus (Mouse) | PR |
| Q9D6K9 | Cers5 | Ceramide synthase 5 | Mus musculus (Mouse) | PR |
| Q6YWS8 | Os02g0728300 | ASC1-like protein 2 | Oryza sativa subsp japonica (Rice) | PR |
| G5ED45 | hyl-1 | Ceramide synthase hyl-1 | Caenorhabditis elegans | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MTSATDKSID | RLVVNAKTRR | RNSSVGKIDL | GDTVPGFAAM | PESAASKNEA | KKRMKALTGD |
| 70 | 80 | 90 | 100 | 110 | 120 |
| SKKDSDLLWK | VWFSYREMNY | RHSWLTPFFI | LVCVYSAYFL | SGNRTESNPL | HMFVAISYQV |
| 130 | 140 | 150 | 160 | 170 | 180 |
| DGTDSYAKGI | KDLSFVFFYM | IFFTFLREFL | MDVVIRPFTV | YLNVTSEHRQ | KRMLEQMYAI |
| 190 | 200 | 210 | 220 | 230 | 240 |
| FYCGVSGPFG | LYIMYHSDLW | LFKTKPMYRT | YPVITNPFLF | KIFYLGQAAF | WAQQACVLVL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| QLEKPRKDYK | ELVFHHIVTL | LLIWSSYVFH | FTKMGLAIYI | TMDVSDFFLS | LSKTLNYLNS |
| 310 | 320 | 330 | 340 | 350 | 360 |
| VFTPFVFGLF | VFFWIYLRHV | VNIRILWSVL | TEFRHEGNYV | LNFATQQYKC | WISLPIVFVL |
| 370 | 380 | 390 | 400 | 410 | |
| IAALQLVNLY | WLFLILRILY | RLIWQGIQKD | ERSDSDSDES | AENEESKEKC | E |