Q5E9R6
PR
Gene name |
CERS4 |
Protein name |
Ceramide synthase 4 |
Names |
CerS4, LAG1 longevity assurance homolog 4, Sphingosine N-acyltransferase CERS4 |
Species |
Bos taurus (Bovine) |
KEGG Pathway |
bta:505233 |
EC number |
2.3.1.24: Transferring groups other than amino-acyl groups |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q5E9R6
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q5E9R6-F1 | Predicted | AlphaFoldDB |
139 variants for Q5E9R6
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs134789392 | 10 | W>G | No | EVA | |
| rs135943549 | 11 | N>D | No | EVA | |
| rs473481991 | 12 | E>D | No | EVA | |
| rs438880934 | 15 | W>G | No | EVA | |
| rs459088411 | 16 | L>I | No | EVA | |
| rs482263657 | 16 | L>P | No | EVA | |
| rs136840938 | 18 | A>P | No | EVA | |
| rs461210287 | 19 | N>H | No | EVA | |
| rs481322185 | 32 | V>G | No | EVA | |
| rs446609341 | 35 | H>P | No | EVA | |
| rs466722323 | 45 | L>M | No | EVA | |
| rs451352113 | 58 | R>S | No | EVA | |
| rs471487942 | 59 | F>S | No | EVA | |
| rs463355427 | 62 | L>P | No | EVA | |
| rs442336776 | 63 | P>H | No | EVA | |
| rs480262518 | 63 | P>T | No | EVA | |
| rs479237125 | 64 | L>P | No | EVA | |
| rs462458266 | 64 | L>V | No | EVA | |
| rs447811005 | 66 | R>P | No | EVA | |
| rs464631999 | 67 | W>G | No | EVA | |
| rs478352262 | 69 | G>R | No | EVA | |
| rs450141882 | 70 | V>E | No | EVA | |
| rs450141882 | 70 | V>G | No | EVA | |
| rs209469182 | 71 | R>Q | No | EVA | |
| rs435589674 | 72 | N>D | No | EVA | |
| rs455449179 | 74 | I>N | No | EVA | |
| rs455449179 | 74 | I>S | No | EVA | |
| rs466043274 | 75 | R>G | No | EVA | |
| rs434543755 | 75 | R>K | No | EVA | |
| rs434543755 | 75 | R>M | No | EVA | |
| rs471458769 | 76 | R>S | No | EVA | |
| rs451401977 | 76 | R>T | No | EVA | |
| rs443343210 | 77 | P>T | No | EVA | |
| rs473779639 | 78 | A>E | No | EVA | |
| rs462422804 | 79 | D>A | No | EVA | |
| rs479370358 | 80 | P>T | No | EVA | |
| rs458270092 | 81 | N>H | No | EVA | |
| rs478249582 | 81 | N>K | No | EVA | |
| rs450078556 | 82 | A>P | No | EVA | |
| rs480390110 | 83 | T>M | No | EVA | |
| rs470138219 | 83 | T>P | No | EVA | |
| rs434683509 | 84 | L>R | No | EVA | |
| rs466037965 | 84 | L>V | No | EVA | |
| rs465116750 | 86 | K>E | No | EVA | |
| rs437027851 | 86 | K>N | No | EVA | |
| rs457006589 | 87 | H>L | No | EVA | |
| rs435942170 | 88 | Y>H | No | EVA | |
| rs435942170 | 88 | Y>N | No | EVA | |
| rs452840612 | 88 | Y>S | No | EVA | |
| rs441481432 | 89 | L>Q | No | EVA | |
| rs471785786 | 90 | M>R | No | EVA | |
| rs458483539 | 90 | M>V | No | EVA | |
| rs443815209 | 91 | K>Q | No | EVA | |
| rs463650501 | 91 | K>R | No | EVA | |
| rs463650501 | 91 | K>T | No | EVA | |
| rs449219674 | 93 | R>G | No | EVA | |
| rs459687185 | 93 | R>Q | No | EVA | |
| rs445079160 | 94 | E>D | No | EVA | |
| rs479897422 | 94 | E>K | No | EVA | |
| rs465295520 | 95 | P>A | No | EVA | |
| rs467428785 | 97 | E>D | No | EVA | |
| rs450735226 | 97 | E>G | No | EVA | |
| rs444329079 | 99 | Q>* | No | EVA | |
| rs481246114 | 99 | Q>H | No | EVA | |
| rs461271821 | 99 | Q>P | No | EVA | |
| rs446647938 | 100 | M>K | No | EVA | |
| rs466585487 | 101 | N>T | No | EVA | |
| rs477141945 | 102 | L>P | No | EVA | |
| rs445751888 | 103 | L>P | No | EVA | |
| rs445751888 | 103 | L>R | No | EVA | |
| rs523293218 | 105 | T>S | No | EVA | |
| rs437592601 | 106 | Q>H | No | EVA | |
| rs468798387 | 106 | Q>P | No | EVA | |
| rs457455546 | 107 | C>G | No | EVA | |
| rs436550764 | 110 | T>K | No | EVA | |
| rs473445881 | 111 | L>P | No | EVA | |
| rs209034764 | 112 | R>Q | No | EVA | |
| rs433304383 | 119 | R>Q | No | EVA | |
| rs797592106 | 121 | R>H | No | EVA | |
| rs444464352 | 135 | E>K | No | EVA | |
| rs520341065 | 148 | V>I | No | EVA | |
| rs478689513 | 149 | C>F | No | EVA | |
| rs447112305 | 153 | V>F | No | EVA | |
| rs467260625 | 153 | V>G | No | EVA | |
| rs432509196 | 154 | L>F | No | EVA | |
| rs446268525 | 155 | Y>H | No | EVA | |
| rs469428276 | 156 | H>L | No | EVA | |
| rs450481080 | 158 | S>L | No | EVA | |
| rs482053688 | 158 | S>P | No | EVA | |
| rs482053688 | 158 | S>T | No | EVA | |
| rs435954913 | 159 | W>* | No | EVA | |
| rs467514020 | 159 | W>G | No | EVA | |
| rs136610110 | 162 | T>A | No | EVA | |
| rs134344078 | 164 | V>G | No | EVA | |
| rs457837243 | 173 | Q>R | No | EVA | |
| rs526229738 | 184 | L>P | No | EVA | |
| rs444304011 | 212 | H>P | No | EVA | |
| rs461231441 | 213 | H>P | No | EVA | |
| rs474796073 | 217 | I>N | No | EVA | |
| rs460035308 | 220 | I>L | No | EVA | |
| rs476910392 | 220 | I>T | No | EVA | |
| rs445753860 | 226 | L>F | No | EVA | |
| rs462373361 | 228 | L>P | No | EVA | |
| rs482721797 | 233 | S>A | No | EVA | |
| rs481634586 | 235 | V>E | No | EVA | |
| rs468070302 | 235 | V>L | No | EVA | |
| rs467023942 | 242 | A>T | No | EVA | |
| rs452660600 | 243 | D>A | No | EVA | |
| rs469379049 | 244 | Y>S | No | EVA | |
| rs438006118 | 245 | L>P | No | EVA | |
| rs474917356 | 247 | E>D | No | EVA | |
| rs483186779 | 282 | T>P | No | EVA | |
| rs483186779 | 282 | T>S | No | EVA | |
| rs467389722 | 292 | S>P | No | EVA | |
| rs435880301 | 298 | P>T | No | EVA | |
| rs472586584 | 301 | G>C | No | EVA | |
| rs471915608 | 311 | I>N | No | EVA | |
| rs451651849 | 311 | I>V | No | EVA | |
| rs462519613 | 338 | K>E | No | EVA | |
| rs476275311 | 344 | V>G | No | EVA | |
| rs444675193 | 350 | S>G | No | EVA | |
| rs461655954 | 357 | E>G | No | EVA | |
| rs481584311 | 358 | C>W | No | EVA | |
| rs447065806 | 366 | A>G | No | EVA | |
| rs460786892 | 367 | Q>R | No | EVA | |
| rs477553415 | 368 | R>G | No | EVA | |
| rs446156244 | 369 | P>L | No | EVA | |
| rs469342954 | 370 | G>R | No | EVA | |
| rs438005305 | 372 | A>P | No | EVA | |
| rs448263804 | 376 | G>A | No | EVA | |
| rs468310110 | 386 | V>A | No | EVA | |
| rs433712115 | 387 | N>T | No | EVA | |
| rs723800182 | 388 | R>W | No | EVA | |
| rs470853689 | 389 | H>L | No | EVA | |
| rs453769507 | 389 | H>N | No | EVA | |
| rs432854847 | 390 | T>P | No | EVA | |
| rs476168475 | 393 | T>K | No | EVA | |
| rs461592867 | 394 | T>S | No | EVA | |
| rs461592867 | 394 | T>W | No | EVA |
No associated diseases with Q5E9R6
Functions
| Description | ||
|---|---|---|
| EC Number | 2.3.1.24 | Transferring groups other than amino-acyl groups |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| endoplasmic reticulum | The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). |
| endoplasmic reticulum membrane | The lipid bilayer surrounding the endoplasmic reticulum. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| DNA binding | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). |
| N-acyltransferase activity | Catalysis of the transfer of an acyl group to a nitrogen atom on the acceptor molecule. |
| sphingosine N-acyltransferase activity | Catalysis of the reaction: acyl-CoA + sphingosine = CoA + N-acylsphingosine. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| ceramide biosynthetic process | The chemical reactions and pathways resulting in the formation of ceramides, any N-acylated sphingoid. |
12 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P38703 | LAG1 | Ceramide synthase LAG1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q3ZBF8 | CERS2 | Ceramide synthase 2 | Bos taurus (Bovine) | PR |
| Q96G23 | CERS2 | Ceramide synthase 2 | Homo sapiens (Human) | PR |
| Q8IU89 | CERS3 | Ceramide synthase 3 | Homo sapiens (Human) | PR |
| Q8N5B7 | CERS5 | Ceramide synthase 5 | Homo sapiens (Human) | PR |
| Q6ZMG9 | CERS6 | Ceramide synthase 6 | Homo sapiens (Human) | PR |
| Q924Z4 | Cers2 | Ceramide synthase 2 | Mus musculus (Mouse) | PR |
| Q9D6K9 | Cers5 | Ceramide synthase 5 | Mus musculus (Mouse) | PR |
| Q8C172 | Cers6 | Ceramide synthase 6 | Mus musculus (Mouse) | PR |
| Q9D6J1 | Cers4 | Ceramide synthase 4 | Mus musculus (Mouse) | PR |
| Q6YWS8 | Os02g0728300 | ASC1-like protein 2 | Oryza sativa subsp japonica (Rice) | PR |
| G5ED45 | hyl-1 | Ceramide synthase hyl-1 | Caenorhabditis elegans | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MWSSLNDWLW | NERLWLPANI | SWAQLEDHDG | LVFPHPQDTL | MAVPLALALV | VVRFTFERFV |
| 70 | 80 | 90 | 100 | 110 | 120 |
| ALPLSRWLGV | RNQIRRPADP | NATLEKHYLM | KGREPTESQM | NLLATQCGLT | LRQTQCWFRR |
| 130 | 140 | 150 | 160 | 170 | 180 |
| RRNQDRPCLT | KKFCESSWKF | VFYLCCFVCG | TMVLYHESWL | WTPVKCWENY | PHQPLKPGLY |
| 190 | 200 | 210 | 220 | 230 | 240 |
| HWYLLELSFY | ISLLMTLPFD | TKRKDFKEQV | IHHFVTIILI | SFSYSLNLLR | IGSLVLLLHD |
| 250 | 260 | 270 | 280 | 290 | 300 |
| SADYLLEASK | LFNYMHWRRM | CDTLFIIFSL | VFFYTRLVLF | PTRILYTTFF | ESIGNFSPFF |
| 310 | 320 | 330 | 340 | 350 | 360 |
| GYYFLNILLV | ILQLLHVFWS | WLILCMIYSF | IKKGQMEKDV | RSDVEELDSS | DGEAAEECPQ |
| 370 | 380 | 390 | |||
| MKNGAAQRPG | AAPTDGPRSR | AAGRMVNRHT | PAT |