G5ED45
Gene name |
hyl-1 (C09G4.1) |
Protein name |
Ceramide synthase hyl-1 |
Names |
HYL-1 |
Species |
Caenorhabditis elegans |
KEGG Pathway |
|
EC number |
2.3.1.24: Transferring groups other than amino-acyl groups |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for G5ED45
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-G5ED45-F1 | Predicted | AlphaFoldDB |
No variants for G5ED45
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for G5ED45 | |||||
No associated diseases with G5ED45
1 regional properties for G5ED45
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | TRAM/LAG1/CLN8 homology domain | 90 - 303 | IPR006634 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.3.1.24 | Transferring groups other than amino-acyl groups |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| axon | The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter. |
| endoplasmic reticulum | The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). |
| endoplasmic reticulum membrane | The lipid bilayer surrounding the endoplasmic reticulum. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| N-acyltransferase activity | Catalysis of the transfer of an acyl group to a nitrogen atom on the acceptor molecule. |
| sphingosine N-acyltransferase activity | Catalysis of the reaction: acyl-CoA + sphingosine = CoA + N-acylsphingosine. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| ceramide biosynthetic process | The chemical reactions and pathways resulting in the formation of ceramides, any N-acylated sphingoid. |
| regulation of locomotion | Any process that modulates the frequency, rate or extent of locomotion of a cell or organism. |
12 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P38703 | LAG1 | Ceramide synthase LAG1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q3ZBF8 | CERS2 | Ceramide synthase 2 | Bos taurus (Bovine) | PR |
| Q5E9R6 | CERS4 | Ceramide synthase 4 | Bos taurus (Bovine) | PR |
| Q8IU89 | CERS3 | Ceramide synthase 3 | Homo sapiens (Human) | PR |
| Q96G23 | CERS2 | Ceramide synthase 2 | Homo sapiens (Human) | PR |
| Q6ZMG9 | CERS6 | Ceramide synthase 6 | Homo sapiens (Human) | PR |
| Q8N5B7 | CERS5 | Ceramide synthase 5 | Homo sapiens (Human) | PR |
| Q8C172 | Cers6 | Ceramide synthase 6 | Mus musculus (Mouse) | PR |
| Q924Z4 | Cers2 | Ceramide synthase 2 | Mus musculus (Mouse) | PR |
| Q9D6J1 | Cers4 | Ceramide synthase 4 | Mus musculus (Mouse) | PR |
| Q9D6K9 | Cers5 | Ceramide synthase 5 | Mus musculus (Mouse) | PR |
| Q6YWS8 | Os02g0728300 | ASC1-like protein 2 | Oryza sativa subsp japonica (Rice) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MWRMSYFWHE | PYWLPRNVTW | PEVPAKFVDL | LVPIYLAIPL | VIIRILWEST | IGVTYLYFRT |
| 70 | 80 | 90 | 100 | 110 | 120 |
| NAYASRKNIT | LLGCMWEHMT | GGFASVSRAK | KILECFWRFS | YYTFAFLYGL | YVMKNSSWLY |
| 130 | 140 | 150 | 160 | 170 | 180 |
| DVKQCWIGYP | FHPVPDTIWW | YYMIETGFYY | SLLIGSTFDV | RRSDFWQLMV | HHVITIFLLS |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SSWTINFVRV | GTLILLSHDV | SDVFLEGGKL | VRYDAHNKNM | TNFMFVLFFS | SWVATRLIYY |
| 250 | 260 | 270 | 280 | 290 | 300 |
| PFIVIRSAVT | EAAALIQPDY | ILWDYQLSPP | YAPRLIVFAL | ILLFFLHIFW | TFIILRIAYR |
| 310 | 320 | 330 | 340 | 350 | 360 |
| TSTGGQAKDV | RSDSDSDYDE | EEMARRERTR | LLKKKKNKVS | PSTDDDDDEG | EEEKNDRKAR |
| HRRAPRKE |