AiPD: Autoinhibited Protein Database

Gene name	Ugp2
Protein name	UTP--glucose-1-phosphate uridylyltransferase
Names	UDP-glucose pyrophosphorylase, UDPGP, UGPase
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:216558
EC number	2.7.7.9: Nucleotidyltransferases
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

1-119 (Predicted disordered autoinhibitory region) PR

1-119 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q91ZJ5-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs3389147717	47	E>D	No	EVA
rs3389150955	72	S>Y	No	EVA
rs3389146334	99	D>E	No	EVA
rs3389139286	112	K>I	No	EVA
rs3389145161	162	M>I	No	EVA
rs3389144105	188	F>S	No	EVA
rs3389084167	196	I>T	No	EVA
rs3389145170	205	A>V	No	EVA
rs3389109561	206	K>N	No	EVA
rs3389147648	206	K>T	No	EVA
rs3389139212	223	H>L	No	EVA
rs3389143873	225	D>E	No	EVA
rs3389145198	263	I>F	No	EVA
rs3389117284	276	C>Y	No	EVA
rs3389144100	286	T>A	No	EVA
rs3389109569	297	Q>H	No	EVA
rs3389143855	300	G>C	No	EVA
rs3389143888	331	N>K	No	EVA
rs3389147670	336	L>H	No	EVA
rs3401823029	342	L>F	No	EVA
rs3402003903	349	D>H	No	EVA
rs3389156799	362	G>S	No	EVA
rs3389121820	376	I>F	No	EVA
rs3389146323	423	E>D	No	EVA
rs3389109573	436	F>L	No	EVA
rs3401333274	438	K>Q	No	EVA
rs3389147694	463	D>Y	No	EVA

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for Q91ZJ5

		Description
EC Number	2.7.7.9	Nucleotidyltransferases
Subcellular Localization	Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

Name	Definition
glucose binding	Binding to D- or L-enantiomers of glucose.
identical protein binding	Binding to an identical protein or proteins.
metal ion binding	Binding to a metal ion.
pyrimidine ribonucleotide binding	Binding to a pyrimidine ribonucleotide, any compound consisting of a pyrimidine ribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety.
UTP:glucose-1-phosphate uridylyltransferase activity	Catalysis of the reaction: alpha-D-glucose 1-phosphate + UTP = diphosphate + UDP-D-glucose.

Name	Definition
brain development	The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.).
glucose 1-phosphate metabolic process	The chemical reactions and pathways involving glucose 1-phosphate, a monophosphorylated derivative of glucose with the phosphate group attached to C-1.
glycogen biosynthetic process	The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues.
glycogen metabolic process	The chemical reactions and pathways involving glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues in alpha-(1->4) glycosidic linkage, joined together by alpha-(1->6) glycosidic linkages.
UDP-glucose metabolic process	The chemical reactions and pathways involving UDP-glucose, uridinediphosphoglucose, a substance composed of glucose in glycosidic linkage with uridine diphosphate.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P32861	UGP1	UTP--glucose-1-phosphate uridylyltransferase	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	PR
Q07130	UGP2	UTP--glucose-1-phosphate uridylyltransferase	Bos taurus (Bovine)	PR
Q16851	UGP2	UTP--glucose-1-phosphate uridylyltransferase	Homo sapiens (Human)	PR