P32861

PR
Gene name
UGP1
Protein name
UTP--glucose-1-phosphate uridylyltransferase
Names
UDP-glucose pyrophosphorylase, UDPGP, UGPase
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YKL035W
EC number
2.7.7.9: Nucleotidyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-133 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

2 structures for P32861

Entry ID Method Resolution Chain Position Source
2I5K X-ray 310 A A/B 12-499 PDB
AF-P32861-F1 Predicted AlphaFoldDB

1 variants for P32861

Variant ID(s) Position Change Description Diseaes Association Provenance
s11-370650 373 G>S No SGRP

No associated diseases with P32861

No regional properties for P32861

Type Name Position InterPro Accession
No domain, repeats, and functional sites for P32861

Functions

Description
EC Number 2.7.7.9 Nucleotidyltransferases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytoplasmic stress granule A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

3 GO annotations of molecular function

Name Definition
metal ion binding Binding to a metal ion.
uridylyltransferase activity Catalysis of the transfer of an uridylyl group to an acceptor.
UTP:glucose-1-phosphate uridylyltransferase activity Catalysis of the reaction: alpha-D-glucose 1-phosphate + UTP = diphosphate + UDP-D-glucose.

5 GO annotations of biological process

Name Definition
(1->6)-beta-D-glucan biosynthetic process The chemical reactions and pathways resulting in the formation of (1->6)-beta-D-glucans.
glycogen biosynthetic process The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues.
glycogen metabolic process The chemical reactions and pathways involving glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues in alpha-(1->4) glycosidic linkage, joined together by alpha-(1->6) glycosidic linkages.
trehalose biosynthetic process The chemical reactions and pathways resulting in the formation of trehalose, a disaccharide isomeric with sucrose and obtained from certain lichens and fungi.
UDP-glucose metabolic process The chemical reactions and pathways involving UDP-glucose, uridinediphosphoglucose, a substance composed of glucose in glycosidic linkage with uridine diphosphate.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q07130 UGP2 UTP--glucose-1-phosphate uridylyltransferase Bos taurus (Bovine) PR
Q16851 UGP2 UTP--glucose-1-phosphate uridylyltransferase Homo sapiens (Human) PR
Q91ZJ5 Ugp2 UTP--glucose-1-phosphate uridylyltransferase Mus musculus (Mouse) PR
10 20 30 40 50 60
MSTKKHTKTH STYAFESNTN SVAASQMRNA LNKLADSSKL DDAARAKFEN ELDSFFTLFR
70 80 90 100 110 120
RYLVEKSSRT TLEWDKIKSP NPDEVVKYEI ISQQPENVSN LSKLAVLKLN GGLGTSMGCV
130 140 150 160 170 180
GPKSVIEVRE GNTFLDLSVR QIEYLNRQYD SDVPLLLMNS FNTDKDTEHL IKKYSANRIR
190 200 210 220 230 240
IRSFNQSRFP RVYKDSLLPV PTEYDSPLDA WYPPGHGDLF ESLHVSGELD ALIAQGREIL
250 260 270 280 290 300
FVSNGDNLGA TVDLKILNHM IETGAEYIME LTDKTRADVK GGTLISYDGQ VRLLEVAQVP
310 320 330 340 350 360
KEHIDEFKNI RKFTNFNTNN LWINLKAVKR LIESSNLEME IIPNQKTITR DGHEINVLQL
370 380 390 400 410 420
ETACGAAIRH FDGAHGVVVP RSRFLPVKTC SDLLLVKSDL FRLEHGSLKL DPSRFGPNPL
430 440 450 460 470 480
IKLGSHFKKV SGFNARIPHI PKIVELDHLT ITGNVFLGKD VTLRGTVIIV CSDGHKIDIP
490
NGSILENVVV TGNLQILEH