Q07130
Gene name |
UGP2 |
Protein name |
UTP--glucose-1-phosphate uridylyltransferase |
Names |
UDP-glucose pyrophosphorylase, UDPGP, UGPase |
Species |
Bos taurus (Bovine) |
KEGG Pathway |
bta:281565 |
EC number |
2.7.7.9: Nucleotidyltransferases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q07130
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q07130-F1 | Predicted | AlphaFoldDB |
37 variants for Q07130
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs472523967 | 18 | S>F | No | EVA | |
| rs453998878 | 18 | S>P | No | EVA | |
| rs439496523 | 20 | F>S | No | EVA | |
| rs451344922 | 23 | V>A | No | EVA | |
| rs443308064 | 24 | I>L | No | EVA | |
| rs480189353 | 26 | Q>P | No | EVA | |
| rs440840574 | 27 | E>A | No | EVA | |
| rs478505646 | 28 | L>P | No | EVA | |
| rs461570634 | 37 | E>* | No | EVA | |
| rs445548506 | 40 | L>H | No | EVA | |
| rs482259366 | 41 | T>I | No | EVA | |
| rs434771120 | 46 | H>Y | No | EVA | |
| rs437910858 | 107 | K>* | No | EVA | |
| rs378564848 | 181 | C>F | No | EVA | |
| rs134615459 | 201 | L>F | No | EVA | |
| rs479278919 | 213 | E>A | No | EVA | |
| rs446393816 | 213 | E>D | No | EVA | |
| rs464739471 | 246 | Y>* | No | EVA | |
| rs468611034 | 248 | F>C | No | EVA | |
| rs435690099 | 248 | F>L | No | EVA | |
| rs456609207 | 248 | F>V | No | EVA | |
| rs454018742 | 277 | E>* | No | EVA | |
| rs472416455 | 283 | T>I | No | EVA | |
| rs440244511 | 289 | D>E | No | EVA | |
| rs461600829 | 320 | S>Y | No | EVA | |
| rs445317101 | 322 | S>* | No | EVA | |
| rs470153862 | 329 | T>K | No | EVA | |
| rs460152690 | 374 | A>P | No | EVA | |
| rs440396470 | 391 | R>C | No | EVA | |
| rs477081250 | 436 | F>L | No | EVA | |
| rs458937535 | 436 | F>L | No | EVA | |
| rs478072149 | 438 | K>N | No | EVA | |
| rs477118191 | 471 | S>* | No | EVA | |
| rs458754430 | 471 | S>A | No | EVA | |
| rs439888983 | 501 | G>R | No | EVA | |
| rs458487632 | 502 | N>S | No | EVA | |
| rs438119856 | 508 | H>Y | No | EVA |
No associated diseases with Q07130
No regional properties for Q07130
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q07130 | |||
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.7.9 | Nucleotidyltransferases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| metal ion binding | Binding to a metal ion. |
| UTP:glucose-1-phosphate uridylyltransferase activity | Catalysis of the reaction: alpha-D-glucose 1-phosphate + UTP = diphosphate + UDP-D-glucose. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| glycogen biosynthetic process | The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues. |
| glycogen metabolic process | The chemical reactions and pathways involving glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues in alpha-(1->4) glycosidic linkage, joined together by alpha-(1->6) glycosidic linkages. |
| UDP-glucose metabolic process | The chemical reactions and pathways involving UDP-glucose, uridinediphosphoglucose, a substance composed of glucose in glycosidic linkage with uridine diphosphate. |
3 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P32861 | UGP1 | UTP--glucose-1-phosphate uridylyltransferase | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q16851 | UGP2 | UTP--glucose-1-phosphate uridylyltransferase | Homo sapiens (Human) | PR |
| Q91ZJ5 | Ugp2 | UTP--glucose-1-phosphate uridylyltransferase | Mus musculus (Mouse) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSRFVQDLSK | AMSQDGASQF | QEVIRQELEL | SVKKELEKIL | TTAPSHEFEH | TKKDLDGFRK |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LFHRFLQEKG | PSVDWGKIQR | PPEDSIQPYE | KIKARGLPDN | VSSVLNKLVV | VKLNGGLGTS |
| 130 | 140 | 150 | 160 | 170 | 180 |
| MGCKGPKSLI | GVRNENTFLD | LTVQQIEHLN | KTYDTDVPLV | LMNSFNTDED | TKKILQKYNH |
| 190 | 200 | 210 | 220 | 230 | 240 |
| CRVKIYTFNQ | SRYPRINKES | LLPVAKNVSY | SGENTEAWYP | PGHGDIYASF | YNSGLLDTFI |
| 250 | 260 | 270 | 280 | 290 | 300 |
| GEGKEYIFVS | NIDNLGATVD | LYILNHLMNP | PNGKPCEFVM | EVTNKTRADV | KGGTLTQYEG |
| 310 | 320 | 330 | 340 | 350 | 360 |
| KLRLVEIAQV | PKAHVDEFKS | VSKFKIFNTN | NLWISLAAVK | RLQEQNAIDM | EIIVNPKTLD |
| 370 | 380 | 390 | 400 | 410 | 420 |
| GGLNVIQLET | AVGAAIKSFE | NSLGINVPRS | RFLPVKTTSD | LLLVMSNLYS | LNAGSLTMSE |
| 430 | 440 | 450 | 460 | 470 | 480 |
| KREFPTVPLV | KLGSSFTKVQ | DYLRRFESIP | DMLELDHLTV | SGDVTFGKNV | SLKGTVIIIA |
| 490 | 500 | ||||
| NHGDRIDIPP | GAVLENKIVS | GNLRILDH |