Q91YQ5
PR
Gene name |
Rpn1 |
Protein name |
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 |
Names |
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 67 kDa subunit, Ribophorin I, RPN-I, Ribophorin-1 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:103963 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q91YQ5
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q91YQ5-F1 | Predicted | AlphaFoldDB |
38 variants for Q91YQ5
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388844618 | 15 | L>I | No | EVA | |
| rs1134852616 | 18 | L>* | No | EVA | |
| rs1134055631 | 18 | L>M | No | EVA | |
| rs3388844965 | 19 | A>T | No | EVA | |
| rs3396600282 | 21 | T>R | No | EVA | |
| rs3388839559 | 131 | V>F | No | EVA | |
| rs3388839559 | 131 | V>I | No | EVA | |
| rs3397013337 | 149 | Q>E | No | EVA | |
| rs3397036726 | 149 | Q>R | No | EVA | |
| rs3388842228 | 158 | E>G | No | EVA | |
| rs3388842901 | 201 | Y>N | No | EVA | |
| rs1133251609 | 222 | N>I | No | EVA | |
| rs1132396767 | 222 | N>Y | No | EVA | |
| rs3388847047 | 239 | H>R | No | EVA | |
| rs3388830011 | 261 | P>S | No | EVA | |
| rs3396951741 | 298 | I>M | No | EVA | |
| rs3397036755 | 298 | I>S | No | EVA | |
| rs3388825531 | 308 | I>V | No | EVA | |
| rs3388844882 | 328 | K>R | No | EVA | |
| rs3388836705 | 377 | E>D | No | EVA | |
| rs3388839513 | 394 | P>S | No | EVA | |
| rs3412748084 | 398 | H>L | No | EVA | |
| rs3388840942 | 402 | L>I | No | EVA | |
| rs3388837584 | 409 | V>M | No | EVA | |
| rs3388830037 | 424 | D>E | No | EVA | |
| rs232384807 | 430 | T>M | No | EVA | |
| rs232384807 | 430 | T>R | No | EVA | |
| rs3388825560 | 444 | V>A | No | EVA | |
| rs246972196 | 446 | A>V | No | EVA | |
| rs3388837614 | 478 | C>Y | No | EVA | |
| rs3388829981 | 482 | Q>* | No | EVA | |
| rs3388844611 | 493 | L>H | No | EVA | |
| rs3388848964 | 522 | T>I | No | EVA | |
| rs3388832868 | 523 | E>K | No | EVA | |
| rs3396606404 | 525 | K>SNLAGHSLVLCL* | No | EVA | |
| rs3388848991 | 540 | T>M | No | EVA | |
| rs3388844952 | 587 | E>K | No | EVA | |
| rs3396767396 | 605 | L>V | No | EVA |
No associated diseases with Q91YQ5
No regional properties for Q91YQ5
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q91YQ5 | |||
7 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| endoplasmic reticulum | The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). |
| endoplasmic reticulum membrane | The lipid bilayer surrounding the endoplasmic reticulum. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| melanosome | A tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored. Melanosomes are synthesized in melanocyte cells. |
| oligosaccharyltransferase complex | A protein complex that is found in the endoplasmic reticulum membrane of eukaryotes and transfers lipid-linked oligosaccharide precursor to asparagine residues on nascent proteins. In yeast, the complex includes at least nine different subunits, whereas in mammalian cells at least three different forms of the complex have been detected. |
| rough endoplasmic reticulum | The rough (or granular) endoplasmic reticulum (ER) has ribosomes adhering to the outer surface; the ribosomes are the site of translation of the mRNA for those proteins which are either to be retained within the cisternae (ER-resident proteins), the proteins of the lysosomes, or the proteins destined for export from the cell. Glycoproteins undergo their initial glycosylation within the cisternae. |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| protein N-linked glycosylation | A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the N4 atom of peptidyl-asparagine, the omega-N of arginine, or the N1' atom peptidyl-tryptophan. |
| protein N-linked glycosylation via asparagine | The glycosylation of protein via the N4 atom of peptidyl-asparagine forming N4-glycosyl-L-asparagine; the most common form is N-acetylglucosaminyl asparagine; N-acetylgalactosaminyl asparagine and N4 glucosyl asparagine also occur. This modification typically occurs in extracellular peptides with an N-X-(ST) motif. Partial modification has been observed to occur with cysteine, rather than serine or threonine, in the third position; secondary structure features are important, and proline in the second or fourth positions inhibits modification. |
5 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P04843 | RPN1 | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 | Homo sapiens (Human) | PR |
| Q6PIX5 | Rhbdf1 | Inactive rhomboid protein 1 | Mus musculus (Mouse) | PR |
| Q9GMB0 | RPN1 | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 | Sus scrofa (Pig) | PR |
| P07153 | Rpn1 | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 | Rattus norvegicus (Rat) | PR |
| Q0DJC5 | OST1A | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1A | Oryza sativa subsp japonica (Rice) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MESPVALLLL | LLLCLGALAP | TPGSASSEAP | PLVNEDVKRT | VDLSSHLAKV | TAEVVLVHPG |
| 70 | 80 | 90 | 100 | 110 | 120 |
| GGSTSRASSF | VLALEPELES | RLAHLGVQIK | GEDEEDNNLE | VRETKIKGKS | GRFFTVKLPV |
| 130 | 140 | 150 | 160 | 170 | 180 |
| ALDPGSKISV | VVETVYTHVL | HPYPTQITQS | EKQFVVFEGN | HYFYSPYPTK | TQTMRVKLAS |
| 190 | 200 | 210 | 220 | 230 | 240 |
| RNVESYTKLG | NPSRSEDVLD | YGPFKDIPAY | SQDTFKVHYE | NNSPFLTITS | MTRVIEVSHW |
| 250 | 260 | 270 | 280 | 290 | 300 |
| GNIAVEENVD | LKHTGAVLKG | PFSRYDYQRQ | PDSGISSIRS | FKTILPAAAQ | DVYYRDEIGN |
| 310 | 320 | 330 | 340 | 350 | 360 |
| VSTSHLLILD | DSVEMEIRPR | FPLFGGWKTH | YIVGYNLPSY | EYLYNLGDQY | ALKMRFVDHV |
| 370 | 380 | 390 | 400 | 410 | 420 |
| FDEQVIDSLT | VKIILPEGAK | NIQVDSPYDI | SRAPDELHYT | YLDTFGRPVI | VAYKKNLVEQ |
| 430 | 440 | 450 | 460 | 470 | 480 |
| HIQDIVVHYT | FNKVLMLQEP | LLVVAAFYIL | FFTVIIYVRL | DFSITKDPAA | EARMKVACIT |
| 490 | 500 | 510 | 520 | 530 | 540 |
| EQVLTLVNKR | LGLYRHFDET | VNRYKQSRDI | STLNSGKKSL | ETEHKAVTSE | IAVLQSRLKT |
| 550 | 560 | 570 | 580 | 590 | 600 |
| EGSDLCDRVS | EMQKLDAQVK | ELVLKSAVEA | ERLVAGKLKK | DTYLENEKLS | SGKRQELVTK |
| IDHILDAL |