Q6PIX5

PR
Gene name
Rhbdf1 (Dist1, Irhom1, Kiaa4242)
Protein name
Inactive rhomboid protein 1
Names
iRhom1, Epidermal growth factor receptor-related protein, Rhomboid family member 1
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:13650
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

21-93 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q6PIX5

Entry ID Method Resolution Chain Position Source
AF-Q6PIX5-F1 Predicted AlphaFoldDB

43 variants for Q6PIX5

Variant ID(s) Position Change Description Diseaes Association Provenance
rs49705406 27 A>V No EVA
rs3402117892 32 A>P No EVA
rs13467094 41 L>V No EVA
rs215990963 42 R>W No EVA
rs3389110678 84 G>R No EVA
rs3389142407 104 K>N No EVA
rs3389086882 127 P>S No EVA
rs3389110693 140 P>Q No EVA
rs3402303037 199 F>L No EVA
rs3389149371 221 A>S No EVA
rs3389110659 225 G>S No EVA
rs3389149426 253 D>Y No EVA
rs3389110689 280 V>E No EVA
rs3402034834 287 A>T No EVA
rs3389124703 317 M>L No EVA
rs3389146741 332 P>S No EVA
rs3389149830 348 A>D No EVA
rs46115126 358 A>S No EVA
rs46115126 358 A>T No EVA
rs3389149420 379 R>Q No EVA
rs3389153830 386 R>L No EVA
rs3389149404 410 W>C No EVA
rs3389120602 447 G>D No EVA
rs3389153833 520 S>L No EVA
rs247958781 531 V>I No EVA
rs3389148063 540 G>C No EVA
rs3389149767 579 K>Q No EVA
rs3389159346 582 A>VSDG* No EVA
rs3401682012 606 G>T* No EVA
rs3389157006 643 L>M No EVA
rs3389157029 666 G>R No EVA
rs3389124697 669 H>Q No EVA
rs255481155 674 V>I No EVA
rs3389146673 697 Y>* No EVA
rs3389146722 698 L>M No EVA
rs3389140640 718 V>I No EVA
rs3389086851 737 Q>L No EVA
rs3389157025 739 W>L No EVA
rs3389145476 747 R>H No EVA
rs3389157056 756 V>M No EVA
rs3412778575 774 I>T No EVA
rs3389124759 779 S>T No EVA
rs3389135701 811 V>I No EVA

No associated diseases with Q6PIX5

1 regional properties for Q6PIX5

Type Name Position InterPro Accession
domain Peptidase S54, rhomboid domain 651 - 789 IPR022764

Functions

Description
EC Number
Subcellular Localization
  • Endoplasmic reticulum membrane ; Multi-pass membrane protein
  • Golgi apparatus membrane ; Multi-pass membrane protein
  • Predominantly localized in the endoplasmic reticulum membrane
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum.
Golgi membrane The lipid bilayer surrounding any of the compartments of the Golgi apparatus.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

6 GO annotations of biological process

Name Definition
cell migration The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms.
cell population proliferation The multiplication or reproduction of cells, resulting in the expansion of a cell population.
negative regulation of protein secretion Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of a protein from a cell.
regulation of epidermal growth factor receptor signaling pathway Any process that modulates the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity.
regulation of proteasomal protein catabolic process Any process that modulates the rate, frequency, or extent of the chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds that is mediated by the proteasome.
regulation of protein secretion Any process that modulates the frequency, rate or extent of the controlled release of a protein from a cell.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P04843 RPN1 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 Homo sapiens (Human) PR
Q91YQ5 Rpn1 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 Mus musculus (Mouse) PR
10 20 30 40 50 60
MSEARRDSTS SLQRKKPPWL KLDIPAAVPP AAEEPSFLQP LRRQAFLRSV SMPAETARVP
70 80 90 100 110 120
SPHHEPRRLV LQRQTSITQT IRRGTADWFG VSKDSDSTQK WQRKSIRHCS QRYGKLKPQV
130 140 150 160 170 180
IRELDLPSQD NVSLTSTETP PPLYVGPCQL GMQKIIDPLA RGRAFRMADD TADGLSAPHT
190 200 210 220 230 240
PVTPGAASLC SFSSSRSGFN RLPRRRKRES VAKMSFRAAA ALVKGRSIRD GTLRRGQRRS
250 260 270 280 290 300
FTPASFLEED MVDFPDELDT SFFAREGVLH EEMSTYPDEV FESPSEAALK DWEKAPDQAD
310 320 330 340 350 360
LTGGALDRSE LERSHLMLPL ERGWRKQKEG GPLAPQPKVR LRQEVVSAAG PRRGQRIAVP
370 380 390 400 410 420
VRKLFAREKR PYGLGMVGRL TNRTYRKRID SYVKRQIEDM DDHRPFFTYW LTFVHSLVTI
430 440 450 460 470 480
LAVCIYGIAP VGFSQHETVD SVLRKRGVYE NVKYVQQENF WIGPSSEALI HLGAKFSPCM
490 500 510 520 530 540
RQDPQVHSFI LAAREREKHS ACCVRNDRSG CVQTSKEECS STLAVWVKWP VHPSAPDLAG
550 560 570 580 590 600
NKRQFGSVCH QDPRVCDEPS SEDPHEWPED ITKWPICTKS SAGNHTNHPH MDCVITGRPC
610 620 630 640 650 660
CIGTKGRCEI TSREYCDFMR GYFHEEATLC SQVHCMDDVC GLLPFLNPEV PDQFYRLWLS
670 680 690 700 710 720
LFLHAGILHC LVSVCFQMTV LRDLEKLAGW HRIAIIYLLS GITGNLASAI FLPYRAEVGP
730 740 750 760 770 780
AGSQFGILAC LFVELFQSWQ ILARPWRAFF KLLAVVLFLF AFGLLPWIDN FAHISGFVSG
790 800 810 820 830 840
LFLSFAFLPY ISFGKFDLYR KRCQIIIFQV VFLGLLAGLV VLFYFYPVRC EWCEFLTCIP
850
FTDKFCEKYE LDAQLH